作者: Lobbezoo, Frank ; Ahlberg, Jari ; Funkhouser, Ellen ; Truong, Clarisse ; Glaros, Alan ; verhoeff, Merel C ; Mungia, Rahma ; Manfredini, Daniele ; Cheney, Charley ; Rugh, John ; Gilbert, Gregg H. ; Taverna, Melanie ; Galang-Boquiren, Maria Therese ; Boone, Honesty

OBJECTIVEBruxism is a repetitive masticatory muscle activity. This study investigates dental practitioners' approaches to bruxism assessment and treatment in practices.METHODSA brief 5 question questionnaire ("Quick Poll") on bruxism was conducted.RESULTSA total of 397 practitioners responded. More than half (55%) initiated treatment for bruxism on one to three patients per month. The majority believed that stress (97%) and sleep patterns (82%) affected bruxism in their patients. Interestingly, 96% offered an occlusal guard/appliance and 46% made occlusal adjustments.CONCLUSIONThis study highlights inconsistencies in practitioner approaches to bruxism assessment and management in clinical settings, suggesting gaps in practitioner knowledge evidenced by the varied responses.ABBREVIATIONSPBRN - Practice-Based Research NetworkMMA - Masticatory muscle activitySB - Sleep bruxismAB - Awake bruxismTMJ - Temporomandibular jointOSA - Obstructive sleep apnea.

2025-05-01·Computer Physics Communications

Logarithmically complex rigorous Fourier space solution to the 1D grating diffraction problem

作者: Levdik, Evgeniy ; Shcherbakov, Alexey A.

The rigorous solution of the grating diffraction problem is a fundamental step in many scientific fields and industrial applications ranging from the study of the fundamental properties of metasurfaces to the simulation of lithog. masks.Fourier space methods, such as the Fourier Modal Method, are established tools for the anal. of the electromagnetic properties of periodic structures, but are too computationally demanding to be directly applied to large and multiscale optical structures.This work focuses on pushing the limits of rigorous computations of periodic electromagnetic structures by adapting a powerful tensor compression technique called the tensor train decompositionWe have found that the millions and billions of numbers produced by standard discretization schemes are inherently excessive for storing the information about diffraction problems required for computations with a given accuracy, and we show that a logarithmically growing amount of information is sufficient for reliable rigorous solution of the Maxwell's equations on an example of large period multiscale 1D grating structures.

2025-04-01·Journal of Vascular Surgery Cases, Innovations and Techniques

Unconventional retrieval of a guidewire fragment from the pulmonary district following retrograde access for chronic limb-threating ischemia

Article

作者: Casilli, Giulia ; Pasqui, Edoardo ; Pasquetti, Leonardo ; Galzerano, Giuseppe ; de Donato, Gianmarco ; Lazzeri, Elisa

Intraprocedural endovascular device fracture and migration is an uncommon complication, with potential catastrophic outcomes. In a 75-year-old woman, retrograde puncture of the superficial femoral artery led to accidental femoral vein puncture and wire coating fragmentation. The fragment migrated up to a sublobar branch of the left pulmonary artery, and again to the right pulmonary artery during the first retrieval attempt. The final retrieval was performed by twisting three 0.014″ wires around the fragment, together with the support provided by the thromboaspiration Indigo-Penumbra catheter. The triple wire twisting technique supported by an aspiration catheter seems to be safe and effective for this serious pulmonary complication.

项与 Universita degli Studi di Siena 相关的新闻（医药）

2025-01-09

·生物谷

葡萄中的齐墩果酸能增加化疗治疗癌症的疗效？！IJMS｜齐墩果酸+喜树碱用于癌症化疗，不仅能降低所需药物的剂量，还能显著提高疗效

在对抗癌症的战场上，靶向作用DNA损伤反应（DDR, DNA Damage Response）是癌症疗法的主要途径之一，然而，许多肿瘤细胞却巧妙地利用了DDR机制的缺陷，不仅促进了自身的生长，还对治疗产生了耐药性，这无疑给患者的生存带来了负面影响。为了寻找新的抗癌武器，研究人员将目光投向了大自然，从天然提取物中识别新型分子，希望为开发新型癌症疗法提供强大的支持。近日，一篇发表在国际杂志International Journal of Molecular Sciences上的研究报告——“Oleanolic Acid Modulates DNA Damage Response to Camptothecin Increasing Cancer Cell Death”，揭示了齐墩果酸（oleanolic acid）作为喜树碱（camptothecin, CPT）疗法后机体DNA损伤反应调节剂的一种新潜力。这项研究由锡耶纳大学等机构的科学家们完成，他们发现，齐墩果酸联合喜树碱用于癌症化疗，不仅能降低所需药物的剂量，还能显著提高疗法的疗效。在这项研究中，研究人员使用核磁共振技术（NMR, Nuclear Magnetic Resonance）从葡萄渣提取物（grape pomace extract）中分离出了齐墩果酸，并观察到它与化疗药物联用时对癌细胞系活性的显著影响。具体来说，当齐墩果酸与喜树碱共同使用时，相比单独使用喜树碱，可以降低化疗药物的浓度，同时达到预期的抗癌效果。更重要的是，在实验中使用的齐墩果酸浓度并不会影响正常细胞的活性。发酵的葡萄提取物或能提高CPT疗法的疗效这一发现就像找到了一个秘密武器，不仅强调了天然提取物作为癌症疗法分子来源的巨大潜力，也为患者带来了好消息：较低剂量的化疗药物可能会减少副作用的发生，使患者更容易耐受治疗过程。这对于那些正在经历艰苦抗癌斗争的人来说，无疑是一个令人振奋的消息。研究人员还进行了其他突破性的研究，例如发现了辣椒素（capsaicin）能增强间皮瘤治疗的潜力，以及在胶质母细胞瘤中找到了能减少血管生长的遗传性靶点。这些进展都进一步证明了自然界的馈赠对于医学研究的重要性。综上所述，本文研究结果强调了齐墩果酸在靶向作用DNA损伤反应中的新角色，特别是在HeLa癌细胞系中，它促进了更具诱变性的DNA修复通路出现和敏感性的增加。通过降低所需的喜树碱药物浓度，齐墩果酸可能成为未来癌症治疗中的一个重要辅助工具，为患者带来更温和、更有效的治疗方案。参考文献： Giulio Mazzarotti,Maria Cuomo,Maria Carmen Ragosta, et al. Oleanolic Acid Modulates DNA Damage Response to Camptothecin Increasing Cancer Cell Death, International Journal of Molecular Sciences (2024). DOI: 10.3390/ijms252413475 本文仅用于学术分享，转载请注明出处。若有侵权，请联系微信：bioonSir 删除或修改！点击下方「阅读原文」，前往生物谷官网查询更多生物相关资讯~

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100 项与 Universita degli Studi di Siena 相关的药物交易

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100 项与 Universita degli Studi di Siena 相关的转化医学

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