Mucosal sites, such as respiratory mucosa, are the primary entry points entry points for pathogens. However, clinical evaluation of vaccines against respiratory respiratory pathogens is currently based primarily on analysis of systemic, i.e. peripheral antibody and cellular responses. These measurements give little indication of the immune responses in respiratory tissues tissues, even though the latter are essential for protection against infection. Protective immune responses in mucous membranes, including respiratory including respiratory tissues, rely on secretory IgA to neutralize pathogens neutralization of pathogens on the mucosal surface, as well as the development of the development of cellular responses, notably those from T (Trm) and B (Brm) lymphocytes. Preclinical studies and a few human studies have demonstrated that Trm are a crucial element mucosal protection against viral and bacterial infections. In fact it has been shown that resident memory lymphocytes, including Trm, are able to able to reside in nasal, pulmonary, intestinal, genital and skin mucosa and skin after infection.

开始日期2025-10-01

申办/合作机构

Centre Hospitalier Universitaire de Saint-Etienne

[+1]

NCT06945081

/ Not yet recruitingN/AIIT

Wilson's Disease Treated With D-Penicillamine: Characterization of Skin Damage Secondary to Treatment by Measuring Skin Elasticity

Wilson's disease is a genetic disorder, resulting from an anomaly present on the ATP7B gene located on chromosome 13, causing a progressive accumulation of copper in various organs such as the liver, nervous system and cornea, leading to various hepatic and neurological disorders and a systemic evolution.
Currently, the first-line treatment for this disease is D-Penicillamine, which acts by chelation and promotes copper excretion through the urine. Unfortunately, this treatment also has significant side-effects, particularly on the skin. However, the pathogenesis of elastopathy in patients with Wilson's disease has yet to be fully characterized, and needs to be better understood in order to adapt the therapeutic strategy.
A silicon mold will be made on Wilson's disease patients, enabling the skin micro-relief to be shaped, and analyzed by confocal laser in comparison with the skin of healthy volunteers.

开始日期2025-06-01

申办/合作机构

Centre Hospitalier Universitaire de Saint-Etienne

NCT02670447

/ Not yet recruitingN/AIIT

Early Identification of Patients Presenting a First Psychotic Episode, Non Answering to First Line Support Strategies: A Multicentric Study

Researchers propose in this project to evaluate predictive factors of non response. It is defined by the lack of symptomatic remission at month 3, for patients presenting a first episode of psychosis. It will be performed on objective markers taken from imagery techniques. The link between evolution of these markers and clinical measures will be studied.

开始日期2025-06-01

申办/合作机构

Centre Hospitalier Universitaire de Saint-Etienne

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项与 Centre Hospitalier Universitaire de Saint-Etienne 相关的文献（医药）

2025-05-01·Soins Psychiatrie

Principe de laïcité et pratiques religieuses en psychiatrie

Article

作者: Pellet, Jacques ; Quenum, Yvonne ; Grosselin, Anne

While French legislation guarantees patients' religious freedom and imposes neutrality on professionals, tensions arise in the interpretation of these principles. In psychiatry, religion can provide comfort and support, or be deleterious depending on the context. Caregivers lack scientific knowledge on this subject, which they are reluctant to broach, and have heterogeneous approaches, sometimes perceived as unfair by patients. Patients report a lack of understanding and support, which can affect their relationship with the teams and their mental health. Deploying training and research on these issues would enable us to better support people in their recovery journey.

2025-05-01·Journal Français d'Ophtalmologie

Genotyping methods for Fuchs corneal endothelial dystrophy

Article

作者: Dorado-Cortez, O ; Touraine, R ; He, Z ; Onitiu, D ; Gain, P ; Trone, M C ; Mascarelli, F ; Harzallah, I ; Thuret, G ; Vaitinadapoule, H

Fuchs endothelial corneal dystrophy (FECD) is a genetic degenerative disease characterized by the progressive degradation of the corneal endothelium, often leading to vision loss. It is the leading cause of corneal transplantation in the Western world. FECD is more common in Europe and the United States, particularly among women. FECD manifests in two forms: an early-onset, rare form linked to mutations in the COL8A2 gene, and a late-onset, more common form associated with the expansion of the CTG18.1 triplet in the TCF4 gene. This expansion is present in about 70% of Caucasian patients with the late-onset form and can cause cellular dysfunctions. In this article, we present a review of the techniques used to genotype variants of genes associated with FECD. Six genotyping methods have been identified. Each method has advantages and disadvantages in terms of cost, throughput, sensitivity, and specificity: STR PCR, TP PCR, Southern Blot, Sanger Sequencing, short-read NGS, and long-read NGS. FECD presents complex genetic challenges. A combined approach using various genotyping techniques is necessary for a comprehensive characterization. Two strategies seem promising for diagnosis and research in this field: (1) the combination of STR PCR and TP PCR followed by short-read or long-read NGS; and (2) long-read NGS alone. These approaches allow for more precise characterization of genetic variants, thus facilitating a better understanding of the underlying mechanisms of FECD.

2025-03-01·Global Spine Journal

MFI-11 Predicts Post-Operative Serious Complications in Patients Undergoing Surgery for Odontoid Fractures

Article

作者: Buhot, Benjamin ; Sylvain, Granges ; Barral-Clavel, Fanelie ; Carlioz, Violette ; Mihail, Gurschi ; Castel, Xavier ; Tetard, Marie-Charlotte ; Sulpis, Benoit ; Vassal, Francois ; Pelletier, Jean-Baptiste ; Charier, David

Study DesignRetrospective Cohort.ObjectivesThe objective of this study was to analyze postoperative complications in different mFI-11 groups after surgery for odontoid fractures in a geriatric population.MethodsA single center retrospective review of odontoid fractures surgery (between 2013 and 2022) in patients aged 65 years and older was conducted. The primary outcome was the occurrence of a major complication (Calvien-Dindo ≥4) within 30 days post-surgery. The secondary outcome was the occurrence of a major complication within 3 months after surgery, and death within 1-month post-surgery. Survival curve, multi-variate analysis was performed and adjusted receiver operating characteristic curves were generated.ResultsThere were 92 patients included in this study, with a mean age of 80.5 years. Serious complication occurred for 16 patients (17%) during hospitalization. Multivariate analysis demonstrated an mFI 11 >.27 was strongly and independently associated with serious complications within 1-month post-surgery (OR = 16.7, 95% CI = 4.50-83), as well as serious complications within 3 months post-surgery (OR = 11.8, 95% CI = 3.48-49.1) and death within 1 month post-surgery (OR = 11.7; 95% CI = 3.02-60.4). The Receiver Operator Characteristics (ROC) curves for the three models all have an Area Under the Curve (AUC) value greater than 0.7.ConclusionsThe mFI-11 is a straightforward and validated tool that can be used during the preoperative period to identify the patient’s level of frailty and assess their risk of postoperative complications. Patients with mFI-11 ≥.27 are at greater risk of serious complications within 1 and 3 months’ post-surgery and death within 1 month post-surgery.

项与 Centre Hospitalier Universitaire de Saint-Etienne 相关的新闻（医药）

2025-02-04

·drugs

Recording of Nystagmus During Vertigo in Meniere Disease May Offer Therapeutic Aid

TUESDAY, Feb. 4, 2025 -- Nystagmus during vertigo attacks in patients with Meniere disease can be video-recorded with a mobile phone and provide a helpful therapeutic aid, according to a study published online Dec. 12 in the Journal of Clinical Medicine . Valéria Ionescu, from the Centre Hospitalier Universitaire de Saint Etienne in France, and colleagues describe the characteristics of nystagmus during vertigo attacks, the feasibility of self-video recording of eye movements by mobile phone, and the therapeutic implication of nystagmus. Patients with definite MD according to the Barany Society were included in the study; they were recorded during their attacks by videonystagmoscopy by the physician and/or mobile phone by the patient or immediate surroundings. Overall, eight, eight, and one patients were video-recorded by mobile phone, videonystagmoscopy, or both, respectively. The researchers found that in 14 patients (seven irritative type, five deficit type, and two changed from deficit to irritative type), the nystagmus was horizontal. In three patients, the nystagmus was vertical (two down-beating and one up-beating); in two patients, the vertical nystagmus changed to a more classical horizontal nystagmus. "The direction of the nystagmus during vertigo attacks in MD is mostly horizontal, although it can be vertical and can change direction," the authors write. "From a diagnostic point of view, the direction of the nystagmus is of no value to deducing the affected side in MD. The nystagmus during vertigo attacks can be video-recorded by the mobile phone of the patient, which is objective proof of the impact on daily life and confirms a disabling MD. From a therapeutic point of view, this was a helpful aid when chemical labyrinthectomy was being considered." Abstract/Full Text Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.

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