Delving into the Latest Updates on Ivanovsky Institute Of Virology with Synapse

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疾病领域	数量

感染	1

排名前五的药物类型	数量

预防性疫苗	1

关联

1

项与 Ivanovsky Institute Of Virology 相关的药物

Herpes simplex vaccine(Ivanovsky Institute Of Virology)

靶点-

作用机制

免疫刺激剂

在研机构

Ivanovsky Institute Of Virology

原研机构

Ivanovsky Institute Of Virology

在研适应症

单纯疱疹

非在研适应症-

最高研发阶段批准上市

首次获批国家/地区

俄罗斯

首次获批日期2017-04-25

100 项与 Ivanovsky Institute Of Virology 相关的临床结果

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0 项与 Ivanovsky Institute Of Virology 相关的专利（医药）

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72

项与 Ivanovsky Institute Of Virology 相关的文献（医药）

2023-08-01·Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections

Higher Infectivity of the Human Immunodeficiency Virus in Sensitive Cells with a Modification of the CCR5 Gene.

Article

作者: Nosik, D N ; Pronin, A V ; Kalnina, L B ; Selimova, L M

As a natural mutation of the human ccr5 gene has been shown to confer resistance to human immunodeficiency virus type 1 (HIV-1) infection, a new avenue has opened in the development of alternative treatment approaches through genome editing. One of the two chemokine co-receptors of the plasma membrane is utilized by HIV-1 to infect CD4⁺ cells. HIV-1 strains that utilize CCR5 circulate in early infection, and strains that utilize CXCR4 circulate at advanced stages. A complex relationship may exist in the expression regulation of the receptors and may affect virus replication in cells that normally do not express CCR5 on the membrane, such as the MT-4 cell line. MT-4 cells were used to study the effect of ccr5 modification HIV-1 replication in vitro. Genetic modification of ccr5 in MT-4 cells was shown to increase the activities of HIV-1 strains, especially in homozygote. The results indicate that genome editing should be performed with caution in human cells and that the issue needs comprehensive investigation.

2021-10-01·Biochimie3区 · 生物学

Dual-targeted anti-CMV/anti-HIV-1 heterodimers

3区 · 生物学

Article

作者: Khandazhinskaya, Anastasia L ; Mercurio, Vincenzo ; Margolis, Leonid ; Kushch, Alla A ; Paramonova, Maria P ; Matyugina, Elena S ; Kochetkov, Sergey N ; Novikov, Mikhail S ; Fedorova, Natalya E ; Ñahui Palomino, Rogers Alberto ; Maslova, Anna A ; Vanpouille, Christophe ; Kukhanova, Marina K ; Tarasova, Olga ; Yurlov, Kirill I

Despite the development of efficient anti-human immunodeficiency virus-1 (HIV-1) therapy, HIV-1 associated pathogens remain a major clinical problem. Human cytomegalovirus (CMV) is among the most common HIV-1 copathogens and one of the main causes of persistent immune activation associated with dysregulation of the immune system, cerebrovascular and cardiovascular pathologies, and premature aging. Here, we report on the development of dual-targeted drugs with activity against both HIV-1 and CMV. We synthesized seven compounds that constitute conjugates of molecules that suppress both pathogens. We showed that all seven compounds exhibit low cytotoxicity and efficiently inhibited both viruses in cell lines. Furthermore, we chose a representative compound and demonstrated that it efficiently suppressed replication of HIV-1 and CMV in human lymphoid tissue ex vivo coinfected with both viruses. Further development of such compounds may lead to the development of dual-targeted anti-CMV/HIV-1 drugs.

2021-09-25·World Journal of Virology

Ambisense polarity of genome RNA of orthomyxoviruses and coronaviruses

Review

作者: Zhirnov, Oleg

Influenza viruses and coronaviruses have linear single-stranded RNA genomes with negative and positive sense polarities and genes encoded in viral genomes are expressed in these viruses as positive and negative genes, respectively. Here we consider a novel gene identified in viral genomes in opposite direction, as positive in influenza and negative in coronaviruses, suggesting an ambisense genome strategy for both virus families. Noteworthy, the identified novel genes colocolized in the same RNA regions of viral genomes, where the previously known opposite genes are encoded, a so-called ambisense stacking architecture of genes in virus genome. It seems likely, that ambisense gene stacking in influenza and coronavirus families significantly increases genetic potential and virus diversity to extend virus-host adaptation pathways in nature. These data imply that ambisense viruses may have a multivirion mechanism, like "a dark side of the Moon", allowing production of the heterogeneous population of virions expressed through positive and negative sense genome strategies.

100 项与 Ivanovsky Institute Of Virology 相关的药物交易

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100 项与 Ivanovsky Institute Of Virology 相关的转化医学

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