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A Single-centre, Open-label Study in Healthy Men to Investigate the Effect of Repeated Oral Doses of ASP2151 on the Pharmacokinetics of Midazolam in Healthy Men

CYP3A4 is involved in the metabolism of many drugs. So, it is important to assess in vivo the induction effect of ASP2151 on that enzyme to determine the extent of any possible drug interactions. The aim of this trial is to investigate the potential for interaction of ASP2151 with the CYP3A4 probe substrate midazolam.

开始日期2015-04-01

申办/合作机构

Maruho Europe Ltd.

NCT02369172 / Completed临床1期

A Single-centre, Open-label Study in Healthy Men to Investigate the Effect of Repeated Oral Doses of ASP2151 on the Pharmacokinetics of Bupropion

CYP2B6 is involved in the metabolism of many drugs. So, it is important to assess in vivo the effect of ASP2151 on that enzyme to determine any possible drug interactions. The aim of this trial is to investigate the potential for interaction of ASP2151 with the CYP2B6 probe substrate bupropion.

开始日期2015-02-01

申办/合作机构

Maruho Europe Ltd.

NCT02321748 / Completed临床1期

A Single-centre, Open-label, Randomised, Crossover, Drug-drug Interaction Study in Healthy Men to Investigate the Effect of a Single Dose of ASP2151 on the Pharmacokinetics of Montelukast

CYP2C8 is involved in the metabolism of many drugs. So, it is important to assess in vivo the inhibitory effect of ASP2151 on that enzyme to determine any possible drug interactions. The aim of this trial is to investigate the potential for interaction of ASP2151 with the CYP2C8 probe substrate montelukast.

开始日期2014-12-01

申办/合作机构

Maruho Europe Ltd.

100 项与 Maruho Europe Ltd. 相关的临床结果

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0 项与 Maruho Europe Ltd. 相关的专利（医药）

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100 项与 Maruho Europe Ltd. 相关的药物交易

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100 项与 Maruho Europe Ltd. 相关的转化医学

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