Fondation du Centre Hospitalier de l'Université de Montréal

Problem:
Currently, no system allows precise kinematic assessment of the knee and accurate guiding of orthopedic surgical actions in a minimally invasive fashion. However, such a system would prove useful in the clinical setting to improve the quality of surgical interventions at the knee.
Hypothesis:
A novel knee kinematic assessment and surgical guidance tool using 3D personalized imaging and minimally invasive bony fixation allows precise kinematic assessment and surgical guidance in the routine clinical setting.
Objectives :
Demonstrating the capacity of the system to precisely measure 3D knee kinematics
Quantifying the reproducibility of the kinematic measurements
Measuring the impact of knee surgical procedures on knee kinematics
Assessing the correlations between measured articular kinematics and clinical results after knee surgery
Integrating the novel measuring system to the surgical flow of three knee surgical procedures
Quantifying the precision and reproducibility of the surgical actions guided by the system
Comparing the clinical results of surgeries guided by the system to those performed with the traditional technique

Problem : Precise and personalized 3D knee kinematic assessment during physical and daily life activities is a challenge; therefore, it was never performed on an important number of individuals. However, a better understanding of 3D knee kinematics during such activities would allow a better understanding of this often injured joint.
Hypothesis: A new system using personalized 3D bone imaging and a percutaneous bone fixation device that can be used under local anesthesiaallows for precise and reproducible assessment of 3D knee kinematics during physical and daily life activities.
Objectives :
* To study human knee 3D kinematics during dynamic activities using a novel minimally invasive measuring system
* Investigate the correlations between standard clinical knee laxity tests and measured 3D knee kinematics during dynamic activities

The purposes of this study are 1) to determine if the administration of different low doses of CBD (5 mg, 20 mg, 50 mg and 100 mg) result in detectable subjective pleasant drug effect compared to placebo and 2) to qualitatively explore whether low dose CBD is associated with effects that are not detected with the available research tools.