Shandong Fangming Pharmaceutical Stock Co. Ltd.

The rubidate synthesis using di-Et phthalate and di-Et succinate was optimized, and yield was 60%.

Objective: To prepare glipizide sustained release tablets and to study its in vitro release activity.Methods: The hydrophilic matrix hydroxypropyl Me cellulose (HPMC) was used to prepare sustained-release tablets by the wet granule compression technique.Orthogonal design was utilized to obtain the best formula.Specifications and the amount of HPMC, diluents and other types of factors affecting the drug release were studied.Results: Glipizide tablets in vitro release behavior were consistent with Higuchi equation.HPMC content and HPMC specifications have some impact on drug release, but the concentration of wetting agents and tableting pressure almost has no effect on the release.Conclusion: HPMC as the basic skeleton material used in combination with other materials, can be prepared glipizide sustained release tablets.

Me 4-hydroxybutanoate was prepared by hydrolysis of γ-butyrolactone, triethylamine as an acid binding agent.Me 4-oxobutanoate obtained by oxidation