A method for determination of polymer content in cefditoren pivoxil tablets by TSK gel chromatog. was established. Exptl. conditions: using a TSK gel G2000 HHR column(300 mmx7.8 mm, 5 μm), the mobile phase is30 mmol/L solution of lithium bromide in N, N-dimethylformamide for liquid chromatog. at the flow rate of 0.3 m L/min, the detection wavelength is 280 nm, the column temperature is 25°C. The results show that the linear range of cefditoren pivoxil is in the range from 0.02 to 148.03 μg/m L, linear equation is y(area of peak) = 85 812 x(concentration)-18 862, r=0.999 6. The detection limit is 0.01 μg/m L, the quantification limit is 0.03 μg/m L. The method is sensitive, accurate and specific, is suitable for detecting the polymers in cefditoren pivoxil tablets.