EFFECTS OF VIRTUAL REALITY WITH MOTOR IMAGERY TECHNIQUES IN ADDITION TO ROUTINE PHYSICAL THERAPY IN PATIENTS WITH PARKINSON’S DISEASE: A RANDOMIZED CONTROLLED TRIAL

开始日期2641-07-06

申办/合作机构

The University of Lahore

IRCT20190912044754N1

/ Suspended早期临床1期IIT

COMPARATIVE EFFECTIVENESS OF ROUTINE PHYSICAL THERAPY WITH AND WITHOUT INSTRUMENT ASSISTED SOFT TISSUE MOBILIZATION IN PATIENTS WITH NECK PAIN DUE TO UPPER CROSSED SYNDROME

开始日期2640-12-11

申办/合作机构

The University of Lahore

IRCT20190325043109N1

/ Suspended临床1期IIT

Effectiveness of Neuromobilization on Pain,Range of motion,Muscle Endurance and Disability in Cervical Radiculopathy,A Randomized Controlled Trial

开始日期2640-06-22

申办/合作机构

The University of Lahore

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7,338

项与 The University of Lahore 相关的文献（医药）

2025-06-01·International Journal of Mathematics and Computer in Engineering

Dispersive modified Benjamin-Bona-Mahony and Kudryashov-Sinelshchikov equations: non-topological, topological, and rogue wave solitons

作者: Zaman, Fiazuddin ; Usman, Muhammad ; Hussain, Akhtar ; Abbas, Naseem ; Ali, Hassan

AbstractThis study delves into the exploration of three distinct envelope solitons within the nonlinear dispersive modified Benjamin Bona Mahony (NDMBBM) equation, originating from seismic sea waves, and the Kudryashov-Sinelshchikov (KS) equation. The solitons emerge naturally during the derivation process, and their existence is scrutinized using the ansatz approach. The findings reveal the presence of non-topological (bright), topological (dark) solitons, and rogue wave (singular) solitons, presenting significant applications in applied research and engineering. Additionally, two-dimensional and three-dimensional revolution plots are employed with varying parameter values to scrutinize the physical characteristics of these solitons.

2025-05-01·Journal of Clinical and Experimental Hepatology

Efficacy and Safety of Ileal Bile Acid Transport Inhibitors in Inherited Cholestatic Liver Disorders: A Meta-analysis of Randomized Controlled Trials

Review

作者: Imran, Muhammad ; Tariq, Muhammad S ; Khan, Sheharyar H ; Abuelazm, Mohamed ; Ali, Mansab ; Elnaggar, Mohamed ; Khalil, Saba ; Ali, Shujaat ; Mehmood, Areeba M ; Elsnhory, Ahmed B ; Ibrahim, Ahmed A

BackgroundInherited cholestatic liver disorders such as progressive familial intrahepatic cholestasis (PFIC) and Alagille syndrome result in significant pruritus and increased serum bile acids, necessitating liver transplantation. This study aims to evaluate the efficacy and safety of Ileal bile acid transport inhibitors (IBATIs) in children with PFIC and Alagille syndrome.MethodsWe conducted a comprehensive search across the databases to identify relevant randomized controlled trials (RCTs), and Covidence was used to screen eligible articles. All outcomes data were synthesized using risk ratios (RRs) or mean differences (MDs) with 95% confidence intervals (CIs) in RevMan 5.4. PROSPERO: CRD42024564270.ResultsFour multicenter RCTs involving 215 patients were included. IBATIs were associated with a significant reduction in Itch Observer Reported Outcome (Itch (ObsRo)) score (MD: -0.90, 95% CI [-1.17, -0.63], P < 0.01), serum bile acids (MD: -119.06, 95% CI [-152.37, -85.74], P < 0.01), total bilirubin (MD: -0.73, 95% CI [-1.32, -0.15], P = 0.01), and increased proportion of patients achieving ≥1 score reduction in Itch (ObsRo) score (RR: 2.54, 95% CI [3.83, 1.69], P < 0.01) and bile acid responders (RR: 8.76, 95% CI [2.46, 31.23], P < 0.01) compared with placebo. No differences were observed in any treatment-emergent adverse events (TEAs) (RR: 1.02, 95% CI [1.12, 0.93], P = 0.71), TEAs leading to drug discontinuation (1.03, 95% CI [5.56, 0.19], any serious TEAs, or liver-related TEAs.ConclusionIBATIs showed significant improvement in various cholestatic parameters with tolerable safety profile; however, future research on optimal dosage and long-term outcomes is needed.

2025-05-01·Biomaterials

Emerging nanomedicines for macrophage-mediated cancer therapy

Review

作者: Liu, Gang ; Yang, Yinxian ; Shi, Xueying ; Askari Rizvi, Syed Faheem

Tumor-associated macrophages (TAMs) contribute to tumor progression by promoting angiogenesis, remodeling the tumor extracellular matrix, inducing tumor invasion and metastasis, as well as immune evasion. Due to the high plasticity of TAMs, they can polarize into different phenotypes with distinct functions, which are primarily categorized as the pro-inflammatory, anti-tumor M1 type, and the anti-inflammatory, pro-tumor M2 type. Notably, anti-tumor macrophages not only directly phagocytize tumor cells, but also present tumor-specific antigens and activate adaptive immunity. Therefore, targeted regulation of TAMs to unleash their potential anti-tumor capabilities is crucial for improving the efficacy of cancer immunotherapy. Nanomedicine serves as a promising vehicle and can inherently interact with TAMs, hence, emerging as a new paradigm in cancer immunotherapy. Due to their controllable structures and properties, nanomedicines offer a plethora of advantages over conventional drugs, thus enhancing the balance between efficacy and toxicity. In this review, we provide an overview of the hallmarks of TAMs and discuss nanomedicines for targeting TAMs with a focus on inhibiting recruitment, depleting and reprogramming TAMs, enhancing phagocytosis, engineering macrophages, as well as targeting TAMs for tumor imaging. We also discuss the challenges and clinical potentials of nanomedicines for targeting TAMs, aiming to advance the exploitation of nanomedicine for cancer immunotherapy.

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