Delving into the Latest Updates on Research Institute for Pharmacy and Biochemistry with Synapse

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3

项与 Research Institute for Pharmacy and Biochemistry 相关的药物

Moxifetin hydrogen maleate

靶点

5-HT receptor

作用机制

5-HT receptor拮抗剂

在研机构-

原研机构

Spofa As

在研适应症-

非在研适应症

重度抑郁症

最高研发阶段终止

首次获批国家/地区-

首次获批日期-

Alaptide

靶点

DRDs

作用机制

DRDs激动剂

在研机构-

原研机构

Research Institute for Pharmacy and Biochemistry

在研适应症-

非在研适应症

阿尔茨海默症 [+3]

最高研发阶段无进展

首次获批国家/地区-

首次获批日期-

7-MEOTA

靶点

AChE

作用机制

AChE抑制剂

在研机构-

原研机构

Prague Psychiatric Center [+1]

在研适应症-

非在研适应症

认知障碍 [+1]

最高研发阶段无进展

首次获批国家/地区-

首次获批日期-

100 项与 Research Institute for Pharmacy and Biochemistry 相关的临床结果

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0 项与 Research Institute for Pharmacy and Biochemistry 相关的专利（医药）

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146

项与 Research Institute for Pharmacy and Biochemistry 相关的文献（医药）

2011-04-12·Journal of Pharmacy and Pharmacology3区 · 医学

Pharmacokinetics and brain entry of alaptide, a novel nootropic agent, in mice, rats and rabbits

3区 · 医学

Article

作者: Lapka, R

AbstractPharmacokinetics of a novel nootropic agent, alaptide, have been examined in plasma and brain of mice, rats and rabbits following an intravenous dose (1 mg kg−1). First-order equilibration rate constants between plasma and brain (kBO) were calculated by a two-compartment model with a linked compartment (brain). Brain alaptide equilibrates rapidly with the central compartment in mice and rats due to the high kBO/β ratio. In rabbits the equilibration is much slower (kBO/β∼ 1). Partition coefficients between brain and plasma calculated from areas under the brain and plasma concentration-time curves, are 0·479, 0·549 and 0·864, in mice, rats and rabbits, respectively.

2011-04-12·Journal of Pharmacy and Pharmacology

Brain as an eliminating organ? A reply

作者: Lapka, R

A reply to comments of V. K. Piotrovskij (ibid., 44:946, 1992).

2002-01-01·Advances in Heterocyclic Chemistry

Aromatic nucleophilic denitrocyclization reactions

作者: Radl, Stanislav

A review.The author discusses aromatic nucleophilic denitrocyclization reactions leading to 5-, 6-, 7-, and 8-membered rings.Oxygen, sulfur, nitrogen, selenium, and carbon nucleophiles are used to form various heterocycles.

100 项与 Research Institute for Pharmacy and Biochemistry 相关的药物交易

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100 项与 Research Institute for Pharmacy and Biochemistry 相关的转化医学

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其他

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当前项目

药物(靶点)	适应症	全球最高研发状态

Moxifetin hydrogen maleate ( 5-HT receptor )	重度抑郁症更多	终止
Alaptide ( DRDs )	皮肤疾病更多	无进展
7-MEOTA ( AChE )	药物性运动障碍更多	无进展