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3

项与 Research Institute for Pharmacy and Biochemistry 相关的药物

Moxifetin hydrogen maleate

靶点

5-HT receptor

作用机制

5-HT receptor拮抗剂

在研机构-

原研机构

Spofa As

在研适应症-

非在研适应症

重度抑郁症

最高研发阶段终止

首次获批国家/地区-

首次获批日期-

Alaptide

靶点

DRDs

作用机制

DRDs激动剂

在研机构-

原研机构

Research Institute for Pharmacy and Biochemistry

在研适应症-

非在研适应症

阿尔茨海默症 [+3]

最高研发阶段无进展

首次获批国家/地区-

首次获批日期-

7-MEOTA

靶点

AChE

作用机制

AChE抑制剂

在研机构-

原研机构

Prague Psychiatric Center [+1]

在研适应症-

非在研适应症

认知障碍 [+1]

最高研发阶段无进展

首次获批国家/地区-

首次获批日期-

100 项与 Research Institute for Pharmacy and Biochemistry 相关的临床结果

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0 项与 Research Institute for Pharmacy and Biochemistry 相关的专利（医药）

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145

项与 Research Institute for Pharmacy and Biochemistry 相关的文献（医药）

2006-11-01·Journal of Heterocyclic Chemistry

Synthetic studies connected with the preparation of h⁺/k⁺‐ATPase inhibitors rabeprazole and lansoprazole

作者: Radl, Stanislav ; Havlicek, Jaroslav ; Klecan, Ondrej

Abstract

magnified image

Synthesis of lansoprazole and rabeprazole using common intermediates is devised. The common intermediates, 2‐[(4‐nitro‐3‐methylpyridin‐2‐yl)methanesulfanyl]‐1H‐benzoimidazole and 2‐[(4‐chloro‐3‐methyl‐pyridin‐2‐yl)methanesulfanyl]‐1H‐benzoimidazole, were prepared in several ways.

2002-01-01·Advances in Heterocyclic Chemistry

Aromatic nucleophilic denitrocyclization reactions

作者: Radl, Stanislav

A review.The author discusses aromatic nucleophilic denitrocyclization reactions leading to 5-, 6-, 7-, and 8-membered rings.Oxygen, sulfur, nitrogen, selenium, and carbon nucleophiles are used to form various heterocycles.

2000-06-01·Archiv der Pharmazie4区 · 医学

Synthesis, Analgesic Activity, and Binding Properties of Some Epibatidine Analogs with a Tropine Skeleton

4区 · 医学

Article

作者: Krejci, Ivan ; Budesinsky, Milo ; Hafner, Wieland ; Radl, Stanislav ; Hejnova, Lucie

A series of epibatidine analogs and their positional isomers bearing an 8-azabicyclo[3.2.1]octane moiety is described. Also some of their simplified analogs bearing a 3-piperidine moiety are reported. Their receptor binding profiles (5-HT1A, 5-HT1B, M1, M2, neuronal nicotinic receptor) and analgesic activity (hot plate, acetic acid induced writhing) have been studied. Some of the compounds, especially those containing an 8-azabicyclo[3.2.1]oct-2-ene moiety possess high afinity for the nicotinic cholinergic receptor. The most analgesically active compounds are also highly toxic. Optimized structures (PM3-MOPAC, Alchemy 2000, Tripos Inc.) of compounds 1-9 were compared with that of epibatidine.

100 项与 Research Institute for Pharmacy and Biochemistry 相关的药物交易

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100 项与 Research Institute for Pharmacy and Biochemistry 相关的转化医学

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其他

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当前项目

药物(靶点)	适应症	全球最高研发状态

Moxifetin hydrogen maleate ( 5-HT receptor )	重度抑郁症更多	终止
Alaptide ( DRDs )	皮肤疾病更多	无进展
7-MEOTA ( AChE )	药物性运动障碍更多	无进展