Background: COVID-19 has spread rapidly in many countries of the world and poses a serious threat to global public health, yet no specific drug has been identified or currently available for its treatment. Since it may take years to design a drug for its treatment, the shortest and most effective way now is to screen the available drugs or active substances by mol. docking methods. Objective: The aim of this study is to investigate the potential for use in COVID-19 treatment by investigating the inhibitory effects of Glycyrrhiza glabra, main active ingredients on COVID-19, main protease (SARS-CoV-2,), SARS-CoV-2 - ACE2 Complex and ACE-2 by mol. docking method, which are known to have antiviral effects on SARS-CoV. Material and Methods: Mol. docking was performed by using Autodock 4.2 to analyze the probability of docking. Several compounds extracted from the root of the licorice plant (glycyrrhizic acid, glabridin, 6-azauridine, pyrazofurin and mycophenolic acid) were docked to inhibit COVID-19 M<sup>pro</sup> and docking results were analyzed by Autodock 4.2 and Biovia Discovery Studio Visualizer 2020. The evaluation was based on the docking score (binding energies) calculated by Autodock 4.2. Nelfinavir was used as standards for comparison. Results: As a result of the study, the compounds of Glabridin in COVID-19 main protease (6LU7), ACE-2 (1R4L) and SARS-CoV-2, - ACE2 Complex (6LZG) have very low binding energy (-8.75 to - 7.64) and low potential to inhibition constant has been found. Conclusion: These results suggest that Glabridin appeared to have the best potential to act as a COVID-19 Msup>pro</sup> inhibitor. However, further research is necessary to investigate their potential medicinal use.