Efficacy of Montelukast in Preventing Transaminase Elevation in Adult Dengue Patients: a Randomized, Double-blind, Placebo Controlled, Superiority Trial

The goal of this clinical trial is to learn if drug montelukast works to treat dengue in adults. It will also learn about the safety of drug montelukast . The main questions it aims to answer are:
Does drug montelukast lower the incidence of liver enzyme elevations in participants ? What medical problems do participants have when taking drug montelukast ?

开始日期2025-01-01

申办/合作机构

Phramongkutklao College of Medicine

TCTR20241218002

/ Not yet recruiting临床4期IIT

A Randomized Controlled Trial of colistin combined with sulbactam versus colistin combined with sulbactam and high dose tigecycline in treatment of carbapenems resistant Acinetobacter baumannii (CRAB) pneumonia

开始日期2024-12-25

申办/合作机构

Phramongkutklao College of Medicine

NCT06496282

/ Recruiting临床3期IIT

The Efficacy of Lemborexant Versus Placebo on Improving Sleep Quality Among Hospital Rotating Shift Workers: A Randomized, Double-Blind, Placebo-Controlled Trial

Shift Work Sleep Disorder (SWSD) are caused by working shifts with a wake-up schedule and sleeping in a way that is different from the natural way of sleeping and avoiding sleep usually results in deviations. of the biological clock (Biological clock), which is an important cause of sleep problems including insomnia, excessive sleepiness or daytime sleepiness these problems was associated cadiovascular events, decrease quality of life and long term working. At the present there are limited information regarding the effectiveness of medications used to promote sleep in shift workers. Lemborexant is specific in binding to orexin type 2, which has a direct effect on sleep. and there are limited biomarkers monitoring from the use of lemborexant including still not found. Which studies have followed depressive symptoms, anxiety symptoms and cognition from a group of people with insomnia, the aim of study to assessment effectiveness of lemborexant on sleep efficiency, quality of life, symptoms of depression, cognition, BDNF, CRP, IL-6 and TNF-alpha levels. of volunteers working on rotating shifts.

开始日期2024-08-01

申办/合作机构

Phramongkutklao College of Medicine

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项与 Phramongkutklao College of Medicine 相关的文献（医药）

2025-01-01·Clinical Epidemiology and Global Health

Incidence and risk factors of recurrent ocular injuries: A multicenter retrospective cohort study in four community hospitals, central Thailand

作者: Narindrarangkura, Ploypun ; Sertsuwankul, Panrawee ; Lertsakulbunlue, Sethapong ; Yaisiri, Panhathai ; Limprungpattanakit, Chanapat

Recurrent ocular injuries increase the risk of long-term ocular complications, which increases public health and economic burden.This study assesses the incidence and risk factors for recurrent ocular injuries in community hospitals in central Thailand, where industrial and agricultural activities heighten risk.This retrospective cohort study enrolled patients from four rural community hospitals over six years (Oct. 1, 2018, to Sept. 17, 2024).Patients with ocular injuries were identified using ICD-10 codes, excluding individuals under 20 and revisits.Data collected included patient demographics, injury characteristics, and healthcare access behaviors.Time-to-event anal. begins from the first ocular injury until a subsequent event or study ends.Statistical analyses identified risk factors, with recurrent events analyzed using the Wei-Lin-Weissfeld model.Of 7189 ocular injury cases, 4373 (60.8 %) were male, with a median age of 43 (IQR 31-57).Most injuries (79.2 %) occurred in industrial settings.Recurrent injuries accounted for 1628 cases (22.7 %), with a rate of 7.6 per 100 person-years.Multivariable anal. showed higher recurrence risk for males (aHR:1.30, 95%CI: 1.07-1.57), age ≥60 (aHR:1.32, 95%CI: 1.04-1.68), and industrial activity (aHR:1.41, 95%CI: 1.10-1.80).Non-urgency cases (aHR:3.32, 95%CI: 1.49-7.42), visits to larger (M2 vs. F2) hospitals (aHR:2.98, 95%CI: 1.43-6.20) and outpatient department (aHR:1.43, 95%CI: 1.18-1.74) compared to the emergency department were also linked to higher recurrence.The findings highlight a substantial incidence of recurrent ocular injuries in rural Thailand, predominantly affecting males and older adults, particularly in industrial sectors.Targeted public health interventions are necessary to enhance injury prevention strategies.

2025-01-01·Respiratory Medicine Case Reports

First case report of isolated pleural cysticercosis demonstrating pleuroscopic findings

Article

作者: Termmathurapoj, Sumeth ; Wattanathum, Anan ; Opartpunyasarn, Pornchai

Pulmonary cysticercosis is a rare manifestation of human cysticercosis, which mostly occurs in developing countries. The disease can affect the lung parenchyma and pleura, resulting in pulmonary nodules, pneumonitis, lung cavities, or pleural effusion. We herein present a case involving a man of advanced age who presented with symptomatic eosinophilic pleural effusion. A computed tomography scan of the chest showed left pleural effusion without lung parenchymal abnormalities. Pleuroscopy revealed novel findings of cysticercal pleural nodules confirmed by histological examination. The patient was diagnosed with isolated pleural cysticercosis. His symptoms and chest radiographic abnormalities improved after treatment with anthelmintic drugs.

2025-01-01·International Journal of STD & AIDS

Clinical characteristics and mortality of tuberculosis among adults living with HIV/AIDS: A single center, retrospective cohort study in Thailand

Article

作者: Lertsakulbunlue, Sethapong ; Nasomsong, Worapong ; Sakboonyarat, Boonsub ; Chaicharoen, Hariwong

Background Tuberculosis (TB) among people living with HIV/AIDS (PLWHA) contributes substantially to morbidity and mortality, particularly in high TB burden countries. Our objective is to investigate the clinical characteristics and mortality rates associated with TB among adult PLWHA over a 10-year period at an urban HIV clinic situated in a high TB burden country. Method A retrospective cohort study was conducted in 2022. The primary endpoints were clinical characteristics and mortality rate of TB, determined as per 100 person-years among adult PLWHA, presented with a 95% confidence interval. Univariable and multivariable Cox proportional regression analyses were performed to determine risk factors for TB mortality. Result From January 2012-December 2022, 155 PLWHA receiving a diagnosis of TB were enrolled. The median age was 29 (26.5–48.5) years, and the median CD4 + T cell count was 141 (41.8–252.8) cells/µL, with 60.0% of patients with TB manifesting as disseminated infection. The most involved organs were pulmonary (89.7%), lymph nodes (39.4%) and pleura (14.8%). The treatment outcomes exhibited success in 63.2% of cases, relapse in 5.2%, loss to follow up in 17.4% and death in 14.2%. The overall mortality rate was 18.8 per 100 person-years. Multivariable analyses showed significant factors affecting mortality, including lymph node involvement (adjusted HR 3.5; 95% CI 1.1–10.8) and thrombocytopenia (adjusted HR 74.2; 95% CI 10.0–551.4). Conclusion TB in PLWHA, commonly presenting as disseminated infection, contributes to high mortality. Lymph node involvement and thrombocytopenia are significant factors contributing to mortality. Tuberculosis preventive treatment should be considered for improved prevention strategies among PLWHA, particularly in high TB burden countries.

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