Nanjing Meirui Pharma Co. Ltd.

Tolterodine tartrate sustained-release tablets were prepared, and the content of tolterodine tartrate was determined by high performance liquid chromatog. (HPLC).Orthogonal design was employed to establish the relationship between the match-ratio of hydroxypropyl methylcellulose (HPMC) to polyvinylpyrrolidone (PVP) and the release rate in vitro.The optimal formulation of tolterodine tartrate sustained-release tablets was as follows: tolterodine tartrate 4 g, HPMC 20 g, mannitol 20 g, dextrin 75 g, 20% PVP and magnesium stearate 2 g.The accumulated release amount of tolterodine tartrate sustained-release tablets was more than 75% within 8 h.HPMC and PVP manufactured by domestic companies can be used properly as barriers to prepare matrix sustained-release tablets of tolterodine tartrate.The formulation and technique are feasible in industry.