Delving into the Latest Updates on Sookmyung Women's University with Synapse

概览

疾病领域	数量

神经系统疾病	1
肿瘤	1

排名前五的药物类型	数量

小分子化药	2

排名前五的靶点	数量

Tubulin(微管蛋白)	1
CAs(碳酸酐酶家族)	1

关联

2

项与 Sookmyung Women's University 相关的药物

SPC-160002

靶点

Tubulin

作用机制

微管蛋白抑制剂

在研机构

Sookmyung Women's University

原研机构

Sookmyung Women's University

在研适应症

肿瘤

非在研适应症-

最高研发阶段临床前

首次获批国家/地区-

首次获批日期-

CAs inhibitors(Sookmyung Women's University)

靶点

CAs

作用机制

CAs抑制剂

在研机构

Sookmyung Women's University

原研机构

Sookmyung Women's University

在研适应症

癫痫

非在研适应症-

最高研发阶段临床前

首次获批国家/地区-

首次获批日期-

2

项与 Sookmyung Women's University 相关的临床试验

ISRCTN79498301

/ CompletedN/AIIT

Research for the effect of biological response modifiers (BRMs) on natural killer (NK) cell cytotoxicity

开始日期2008-05-01

申办/合作机构

Sookmyung Women's University

ACTRN12611000655943

/ Completed临床1/2期IIT

A six-month supplementation of mulberry, Korean red ginseng and banaba decreases biomarkers of systemic low grade inflammation in subjects with impaired glucose tolerance and type 2 diabetes

开始日期2007-03-01

申办/合作机构

Sookmyung Women's University

[+1]

100 项与 Sookmyung Women's University 相关的临床结果

登录后查看更多信息

0 项与 Sookmyung Women's University 相关的专利（医药）

登录后查看更多信息

5,349

项与 Sookmyung Women's University 相关的文献（医药）

2025-06-01·Separation and Purification Technology

Four-bed vacuum pressure swing adsorption for xenon recycling from semiconductor waste gas

作者: Park, Kyungtae ; Choi, YeonJi ; Choi, Kyung Min

The development of the space industry, increasing semiconductor production, and growing demand for medical xenon has significantly boosted the xenon market.However, the com. production of cryogenic distillation is an energy intensive process and results in economic and environmental issues.In this study, exptl. adsorbent data collection and a vacuum pressure swing adsorption (VPSA) simulation are presented for recovering and purifying xenon from semiconductor waste gas containing 0.1 mol% Xe and 99.9 mol% _N2.FMOFCu was used for xenon adsorption, and the adsorption data were collected through isotherm and breakthrough experiments using Xe and _N2.Further, the VPSA process was designed and parametric studies were conducted using gPROMS simulations based on exptl. data.Consequently, 99.9 % of the xenon product was produced through a two-stage VPSA process, and an economic and environmental evaluation of the produced xenon was conducted.The min. selling price of the produced xenon ranged from 554.42 to 1482.08 $/kgXe, which was more than 1000 $/kgXe lower than the current wholesale price of xenon.The electricity consumption of the proposed VPSA process was 40.99 kWh, and the calculated global warming potential was 28.92 kg C_O2 eq for 1 kg of Xe produced.Therefore, the proposed VPSA process was economical and environmentally sustainable.

2025-04-01·Biosensors and Bioelectronics

Fc-binding M13 phage-enhanced electrochemical biosensors for influenza virus detection

Article

作者: Chung, Woo-Jae ; Cho, Won Woo ; Lee, Sang-Myung ; Lee, Sang Min ; Shin, Dong-Sik ; Chang, Seo Hyeon ; Lee, Sang Hyun ; Kwak, Eun-A

The importance of in vitro diagnostics (IVDs) has significantly increased, driving the demand for rapid and sensitive diagnostic platforms. Molecular probes play a pivotal role in improving the sensitivity and accuracy of IVDs because of their target-specific signal transduction capabilities. Antibodies, which are commonly used as detection probes, face several challenges, including limited stability, high production costs, and low signal output. In this study, we developed an engineered M13 bacteriophage-based detection system for influenza virus hemagglutinin (HA) using an Electrical ImmunoSorbent Assay (El-ISA). Our design featured Fc-binding motifs on pIII to enable conjugation with target-specific antibodies, along with signal-enhancing biotin modifications on pVIII. The resulting Fc-binding phage probes combined with anti-HA antibodies significantly improved the signal intensity by up to 6.0-fold. This approach enabled the detection of viral proteins in lysate samples at concentrations as low as 44.9 pfu/mL. These findings demonstrated the potential of Fc-binding phage probes as versatile platforms that synergize antibody specificity with enhanced signal transduction. This strategy not only enhances the sensitivity of antibody-based diagnostics but also expands their applicability in diverse research and diagnostic settings.

2025-03-01·Sensors and Actuators B: Chemical

Ratiometric fluorophores to ONOO– in living cells and monitoring endothelial dysfunction

作者: Park, Sun Young ; Kim, Na Yoon ; Kim, Jongmin ; Lee, Min Hee ; Kang, Chulhun ; Lee, Aram ; Jo, Eun-Young

Peroxynitrite (ONOO^-), generated from nitric oxide and superoxide, is implicated in cellular dysfunction and death.To detect ONOO^- in live cells, we developed two hemicyanine-based ratiometric fluorophores, P-mito and P-boc.These ratiometric fluorophores were successfully used to monitor ONOO^- fluctuations in cancer cells and endothelial cells.P-mito predominantly accumulated in the mitochondria of live cells and, upon selective reaction with ONOO^-, increased the ratio of the fluorescence intensity from blue channel to that from red channel.Treatment with an ONOO^- scavenger, N-acetyl cysteine, suppressed this ratio increase.Notably, in a model of endothelial dysfunction induced by treating pulmonary arterial endothelial cells with TGFβ2 and IL-1β, our system successful demonstrated increased ONOO^- levels, effectively highlighting the utility of the hemicyanine-based fluorescence response to ONOO^-.Therefore, our hemicyanine-based ONOO^- detection system provides an effective platform for spatiotemporal monitoring and quant. anal. of ONOO^- within live cells, enabling mol.-level research into various ONOO^--related pathol. conditions.

100 项与 Sookmyung Women's University 相关的药物交易

登录后查看更多信息

100 项与 Sookmyung Women's University 相关的转化医学

登录后查看更多信息