Ankara University

The aim of this project is to examine the effects of the Laughter Yoga Supported Strong Woman, Safe Life Education Program applied to women on attitudes towards violence, stress coping styles and psychological flexibility.
The problem of violence against women is a public health problem that affects and concerns not only women at the individual level, but also children, all family members and therefore society. According to the data of the Turkish Statistical Institute in our country, 38% of women have been subjected to spousal or partner violence at some point in their lives. Violence or the threat of violence that causes fear, pain and anxiety in women from an individual perspective; constitutes an obstacle to women's more active and productive participation in economic and social life, especially in the private sphere. From a social perspective, the economic cost of violence against women is extremely high in terms of loss of working hours and wages, social services, legal and medical expenses.
Our country has a culturally patriarchal social structure. Living in a patriarchal order affects beliefs and attitudes towards the acceptance of violence, making women more vulnerable to violence. Living in a patriarchal order affects beliefs and attitudes towards acceptance of violence, making women more vulnerable to violence. When the reasons for submissive behaviors towards violence are examined, it is stated that factors such as having children, low self-esteem, religious beliefs, social pressure, emotional attachment to a long-term relationship, running away from home, arranged marriage, being economically dependent on the spouse and low level of education are effective. Accepting violence encourages aggression and causes violent people to legitimize their actions. It is stated that submissive and accepting attitudes towards violence can be changed. Interventions aimed at empowering women play an important role in reducing attitudes accepting violence. It is anticipated that this project will create an opportunity for women to raise awareness about violence and change their accepting attitudes towards violence.
The proposed project consists of THREE stages. The first stage, PREPARATION stage; includes preparation of data collection tools, determination and informing of scholarship recipients, development of training content and tools, preliminary application and determination of the working group. The second stage is the IMPLEMENTATION stage, which includes collecting pre-test data, loading public transportation fees onto participants' cards for transportation, providing training to the intervention group, and collecting post-test data. The third stage is the MONITORING-EVALUATION stage, which is the stage of collecting follow-up test data and conducting analyses.
The research will be conducted as a randomized controlled parallel group intervention study. The universe of the research will consist of 7988 women registered in 24 Women's Education and Culture Centers (KEKM) affiliated with Altındağ Municipality. 1 center will be randomly selected from 24 Women's Education and Culture Centers for the sample of the research. In this study, the smallest sample size was determined as 43 for each group, totaling 86, at 80% statistical power and α=.05 significance level. Considering the 10% data loss in the determined sample size, it was planned to include a total of 94 participants, 47 for each group. The assignment of the women included in the research to the intervention (47 participants) and control (47 participants) groups will be done by randomization method. The aim is to implement the Laughter Yoga Supported Strong Woman, Safe Life Training Program face-to-face for an 8-week period for the participants in the intervention group. The 47 participants in the intervention group will be divided into 3 separate groups (16 participants, 16 participants and 15 participants) to increase interaction and experience sharing. The project team will implement the Laughter Yoga Supported Strong Woman, Safe Life Training Program consisting of 8 modules to 3 separate groups. The intervention group will be given a pre-test before the training, a post-test after the training and a follow-up test 1 month after the training is completed. It is planned to collect data by conducting a pre-test, post-test and follow-up test simultaneously with the experimental group without any intervention for the control group. Data will be collected using the Attitude Towards Violence in Close Relationships Scale, the Psychological Flexibility Scale and the Styles of Coping with Stress Scale. Institutional permission will be obtained from the Ankara University Ethics Committee and the Altındağ Municipality.
In this project, with the "Strong Woman, Safe Life Training Program Supported by Laughter Yoga", women will be provided with training on the Importance of Self-Knowledge and Communication, Stress and Coping Techniques, Gender, Empowerment

Ga-68-FAPI has recently been proven to be superior to F-18-FDG in various cancers. These results have also raised hope in using FAP radiopharmaceuticals with theranostic approach. Lu-177 bound FAPI molecules have been started to be used in some cancers in clinical trials following its efficacy proven by case reports. Similarly,as a pilot study, this project aims to investigate safety and efficacy of Lu-177- FAP-2286 in metastatic urothelial carcinomas of bladder.
A total of 10 histopathologically proven urothelial bladder cancer patients >18y of age will be included in the study. After taking informed consent, all patients will undergo both 18F-FDG PET/CT and 68Ga-FAPI PET/CT for restaging before initiation of Lu-177-FAP-2286. Patients who show progression despite advanced therapies and high Ga-68 FAPI uptake will be enrolled. Patients with histopathologically proven advanced stage urothelial bladder cancer refractory to all standard therapies and no standard treatments are available or are contraindicated. Radiopharmaceutical will be administered 150mCi fixed dose, 3 cycles, 8 weeks interval. Posttherapy whole body SPECT/CT imaging will be obtained 4.,24.,96,120Hours of treatment for dosimetric calculations. All patients will be monitored for safety issues and possible long term side effects. Hematological tests, renal and liver function tests will be performed every 2 weeks, radiological imaging for tumor response assessment will be performed every 6 weeks. Symptoms will be taken under consideration for symptomatic response QoL questioner. In case of objective progression, therapy will be stopped. Otherwise, will be completed to 4 cycles.
Administration of Lu-177 FAPİ treatment will be performed by 1st partner from Turkey. Posttreatment SPECT/CT images will be obtained and collected for dosimetric calculations. Heatly organ doses and tumor doses will be calculated bt 2nd partner form Italy in collaboration with 1st partner. In consideration of the advances in radionuclide treatments to achieve objective response within safety margins to healthy organs, dosimetric approaches are mandatory. As a novel treatment dosimetric data for Lu-177 FAPİ treatment is limited. Despite to being a reference center for radionuclide treatments 1st partner has no experience on dosimetric calculations for systemic radionuclide treatments. As an experienced center for dosimetric studies, 2nd partner will be a milestone for analysis of dose response and toxicity analyses for this pilot study of novel treatment.

The aim of this study is to compare, in a multidimensional manner, the effectiveness of different educational methods-virtual patient simulation and peer simulation-in improving sexual counseling skills during pregnancy among nursing faculty students.
The study will evaluate three different training methods: virtual patient simulation, peer simulation conducted in a virtual environment, and face-to-face peer simulation. To determine the effectiveness of peer simulation and virtual patient simulation in sexual health counseling, multimodal data collection and analysis methods will be used. These methods will contribute to the development of counseling skills by examining in detail the verbal and non-verbal communication elements exhibited by participants during their interactions with virtual patients and peers. Throughout the research process, students' demographic characteristics, sexual attitudes and beliefs, sexual counseling skills, learning satisfaction and self-confidence levels, opinions on system usability, eye-tracking data, and body movements will be analyzed.