A Comparative Analysis of the Effectiveness, Usability, Uptake, and Acceptability of an Educational Website and a Mobile Health Application Prototype in Improving Knowledge on Oral Cancer

Introduction: Oral cancer is a malignant neoplastic disease affecting the lip, oral cavity (mouth) and/or the oropharynx. Despite the intense and diverse public health interventions on oral cancer prevention, the global prevalence rates of oral cancer and its major risk factors are still very high. Hence, oral cancer is an issue of serious global health importance.
Aim: To test and compare the effectiveness, usability, uptake, and acceptability of an educational website and a mobile health application prototype on oral cancer in improving oral cancer knowledge among university students.
Methods: This study will adopt a randomised control trial design, and it will be conducted among 75 first-year bachelor's degree students from five universities across two continents: University of Rwanda (Rwanda, Africa), Usmanu Danfodiyo University (Nigeria, Africa), University of Peradeniya (Sri Lanka, Asia), University of Ibadan (Nigeria), and Saveetha University (India, Aisa). The study participants will be in three groups (Group 1, Group 2, and Group 3). The participants in Group 1 will be the control group (n = 25 participants; 5 participants from each university); that is the group that will not receive an educational intervention. However, those in Group 2 (n = 25 participants; 5 participants from each university) will receive a web-based educational intervention on oral cancer while those in Group 3 (n = 25 participants; 5 participants from each university) will receive an app-based educational intervention on oral cancer. Pretest survey and posttest survey will be done for all participants. The data collected will be statistically analysed using the Statistical Package for Social Sciences (SPSS) version 28 software. Descriptive statistics will be done for all variables while inferential statistics (analysis of variance) will be done to test for associations between variables of interest.
Conclusion: The findings of this study will determine the effectiveness, usability, uptake, and acceptability of the tested digital intervention tools.

开始日期2025-01-05

申办/合作机构

University of Rwanda

[+4]

NCT06780904

/ RecruitingN/AIIT

Comparing the Efficacy of Dry Needling Combined with Passive Stretching and Muscle Energy Technique on Upper Trapezius Myofascial Trigger Points Associated with Neck Pain

The goal of this clinical trial is to assess and compare the efficacy of dry needling (minimally invasive treatment by using a tiny needle) combined with two types of stretching techniques in patients with neck pain for more than 3 months. The main questions it aims to answer are:
Which combination of treatment will 1.give faster relief of pain? 2.improve neck range of motion? and 3.improve disability level of a person with neck pain.
Participants who are interested will be selected according to eligibility criteria. Participants will be divided into two groups. Initially researcher will assess and interview the participants. Two groups will receive two different combinations of interventions. Pre and post measurements will be obtained and then treatment efficacy will be assessed.

开始日期2024-09-01

申办/合作机构

University of Peradeniya

SLCTR/2024/029

/ RecruitingN/AIIT

Effects of functional electrical stimulation (FES) for the motor functions of upper limb and activities of daily living (ADLs) in acute and sub-acute stroke patients.

开始日期2024-08-30

申办/合作机构

University of Peradeniya

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2025-04-01·Patient Education and Counseling

Effectiveness of a Calgary-Cambridge model-based communication skills training for paediatric trainees in Sri Lanka: A nationwide pre-post intervention study using observed practices

Article

作者: Caldera, Dihan ; Krishnapradeep, Sinnarajah ; Wijayasinghe, Hashini ; Dayasiri, Kavinda ; Mudiyanse, Rasnayaka

OBJECTIVETo evaluate the effectiveness of a Calgary-Cambridge model-based communication skills training program for postgraduate paediatric trainees in Sri Lanka.METHODSA pre-post intervention study was conducted among 133 paediatric trainees across Sri Lanka. The training program focused on relationship-building, information gathering, and information giving. Communication skills were assessed using an OSCE with simulated patients and a 12-item checklist. Paired t-tests were used to analyze score differences.RESULTSSignificant improvements were observed across all domains. Relationship-building scores increased from 13.5 to 23, information gathering from 12.6 to 20.2, and information giving from 13.3 to 24.8 (p < 0.01 for all). Relationship-building correlated positively with information gathering (r = 0.626) and giving (r = 0.600, p < 0.01). Trainees with prior communication training scored higher post-intervention (mean difference = 10.5, p = 0.019). No gender differences were observed.CONCLUSIONThe Calgary-Cambridge model-based training program effectively enhanced communication skills among Sri Lankan paediatric trainees.PRACTICE IMPLICATIONSIncorporating structured communication skills training into postgraduate curricula is essential, particularly in culturally diverse medical settings.

2025-03-01·The Journal of Nutritional Biochemistry

Thermogenic adipose tissues: Promising therapeutic targets for metabolic diseases

Review

作者: Ramalingam, Latha ; Pham, Kenneth ; Pahlavani, Mandana ; Abidi, Hussain ; Kalupahana, Nishan Sudheera ; Morovati, Ashti ; Moustaid-Moussa, Naima ; Kiridana, Vasana

The ongoing increase in the prevalence of obesity and its comorbidities such as cardiovascular disease, type 2 diabetes (T2D) and dyslipidemia warrants discovery of novel therapeutic options for these metabolic diseases. Obesity is characterized by white adipose tissue expansion due to chronic positive energy balance as a result of excessive energy intake and/or reduced energy expenditure. Despite various efforts to prevent or reduce obesity including lifestyle and behavioral interventions, surgical weight reduction approaches and pharmacological methods, there has been limited success in significantly reducing obesity prevalence. Recent research has shown that thermogenic adipocyte (brown and beige) activation or formation, respectively, could potentially act as a therapeutic strategy to ameliorate obesity and its related disorders. This can be achieved through the ability of these thermogenic cells to enhance energy expenditure and regulate circulating levels of glucose and lipids. Thus, unraveling the molecular mechanisms behind the formation and activation of brown and beige adipocytes holds the potential for probable therapeutic paths to combat obesity. In this review, we provide a comprehensive update on the development and regulation of different adipose tissue types. We also emphasize recent interventions in harnessing therapeutic potential of thermogenic adipocytes by bioactive compounds and new pharmacological anti-obesity agents.

2025-02-01·Materials Chemistry and Physics

Fine-tuning electronic and semiconducting properties of Co-MOF-74 upon encapsulating aniline and its derivatives

作者: Hettiarachchi, Champika ; Perera, Ishanie ; Jayasundara, Thushani

Metal-organic frameworks (MOFs) are multifunctional inorganic-organic hybrid 3D networks that can be fine tuned through various modifications, making them semiconductive and highly adaptable in many applications.In this study, the semiconducting behavior of a notable MOF, Co-MOF-74 was enhanced, via post-synthetic modifications.Electron-rich guest mols.; aniline, m-toluidine, p-toluidine, o-anisidine, and p-anisidine were encapsulated into the honeycomb-shaped channels in Co-MOF-74 structure using the vapor phase encapsulation method.The successful synthesis of Co-MOF-74 was confirmed through powder X-ray diffraction, showing major diffraction peaks at approx. 6.7° and 11.7°, corresponding to the (2-10) and (300) crystal planes, resp.Fourier-transform IR anal. proved the successful encapsulation of the guest mols., as evidenced by band shifts towards lower wavenumber values in the 1700-1300 cm^-1 region.The encapsulation of guest mols. significantly reduced the bandgap of Co-MOF-74, from 2.72 eV for the pristine Co-MOF-74 to 1.89, 2.56, 2.54, 2.14, and 1.92 eV upon encapsulation with aniline, m-toluidine, p-toluidine, o-anisidine, and p-anisidine, resp. and flat band potentials reduced, and carrier concentrations improved.These results highlight the potential of using Co-MOF-74 for enhanced semiconducting applications through targeted guest mol. encapsulation.Hence, to improve the cost-effectiveness of dye-sensitized solar cells, modified Co-MOF-74 systems were applied as both semiconducting and sensitizing materials in fabricating MOF-sensitized solar cells (MSSC).Upon electro-polymerization via cyclic voltammetry anal., the MSSC efficiencies improved to 0.01 %, indicating promising advancements in the efficiency of MOF-sensitized solar cells.

项与 University of Peradeniya 相关的新闻（医药）

2021-01-28

·BioSpace

Venatorx Pharmaceuticals Names New Head of Regulatory Affairs

Chitrananda Abeygunawardana, Ph.D. will lead the development and execution of Venatorx’s global regulatory strategy for its clinical and pre-clinical anti-infectives programs MALVERN, Pa.--(BUSINESS WIRE)-- Venatorx Pharmaceuticals today announced that Chitrananda Abeygunawardana, Ph.D. has been named Vice President, Regulatory Affairs. With nearly 25 years’ experience in pharmaceutical research, regulatory affairs and compliance, Dr. Abey will be responsible for developing and executing all regulatory strategies and tactics for Venatorx’s antibacterial and antiviral programs including interacting with health authorities and managing clinical trial applications worldwide. This press release features multimedia. View the full release here: Chitrananda Abeygunawardana, Ph.D. -- Vice President, Regulatory Affairs at Venatorx Pharmaceuticals, Inc. (Photo: Business Wire) “We are proud to continue to attract the best and brightest minds to Venatorx to support our mission to bring lifesaving antibiotics and antiviral medicines to patients around the globe,” said Christopher J. Burns, Ph.D., President and CEO of Venatorx. “Dr. Abey will play a critical role in advancing our antibiotic and antiviral programs from benchtop to bedside. I look forward to working with him as we progress our programs to market.” “We have witnessed first-hand the colossal impact a global pandemic can have on our way of life,” said Dr. Abey. “I am excited by the opportunity to be part of a company that is addressing critical unmet medical needs for patients, and working hard every day to thwart what could be the next global pandemic—antimicrobial resistance.” Prior to joining Venatorx, Dr. Abey was Executive Director of Merck Global Regulatory Affairs and Clinical Safety (GRACS) where he led the development of Merck’s pneumococcal vaccine strategy, and developed the regulatory strategies to support new drug development and licensures. During his tenure at Merck, Dr. Abey was a key contributor in the development of strategies for multiple anti-infectives including vaccines, antivirals and antifungals, as well as immune-oncology, representing every stage of drug development from pre-clinical concept to life cycle management of approved products. Dr. Abey has extensive experience in formulating late stage clinical and regulatory strategy to maximize value through optimal labeling indications and content, and in leading discussions with the FDA (CBER, CDER, & CDRH) and representing Merck in discussions with other key ex-US Agencies (EMA, Health Canada, PMDA, PEI, CFDA, etc.). In addition, Dr. Abey has extensive expertise in analytical and manufacturing aspects of vaccines and biologics, cGMPs, devices, content labeling, and manufacturing investigations. Dr. Abey received his Ph.D. in Chemistry from UMBC in Baltimore, Maryland and his B.S. in Chemistry from the University of Peradeniya in Sri Lanka. In addition, he was a member of the Research Faculty at Johns Hopkins School of Medicine. About Venatorx Pharmaceuticals Venatorx Pharmaceuticals is a private pharmaceutical company focused on improving health outcomes for patients with multi-drug-resistant bacterial infections and hard-to-treat viral infections. For more information, please visit . View source version on businesswire.com:

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