Effect of cephaloid vs. caudally threaded labor epidural catheter in achieving adequate sensory block for normal delivery/caesarean section-a randomized control study - NIL

开始日期2024-12-01

申办/合作机构

Amrita Institute of Medical Sciences

CTRI/2024/10/075905

/ Not yet recruiting临床2期

Effects of deep respiration on the incidence of accidental intravascular placement of labour epidural catheter- a randomised control study. - NIL

开始日期2024-11-30

申办/合作机构

Amrita Institute of Medical Sciences

100 项与 Amrita Institute of Medical Sciences 相关的临床结果

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0 项与 Amrita Institute of Medical Sciences 相关的专利（医药）

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1,808

项与 Amrita Institute of Medical Sciences 相关的文献（医药）

2025-02-01·Hepatology

Performance of spleen stiffness measurement to rule out high-risk varices in patients with porto-sinusoidal vascular disorder

Article

作者: Wong, Yu Jun ; Procopet, Bogdan ; Gudavalli, Koushik ; Simon-Talero, Macarena ; Noronha Ferreira, Carlos ; Mallet, Vincent ; Vidal-González, Judit ; Moga, Lucile ; Caccia, Riccardo ; Tosetti, Giulia ; Castera, Laurent ; Fodor, Andreea ; Rautou, Pierre-Emmanuel ; Colecchia, Antonio ; Nicoara-Farcau, Oana ; Macedo, Guilherme ; Antonenko, Antonina ; Houssel-Debry, Pauline ; Valsan, Arun ; Balcar, Lorenz ; Monllor-Nunell, Teresa ; Elkrief, Laure ; Ferrusquía-Acosta, José ; Turco, Laura ; Ferreira-Silva, Joel ; Lannes, Adrien ; Ronot, Maxime ; Indulti, Federica ; Paradis, Valérie ; Vitale, Giovanni ; Ravaioli, Federico ; Vilgrain, Valérie ; Payancé, Audrey ; Turon, Fanny ; Capinha, Francisco ; Poujol-Robert, Armelle ; Rampally, Sai Prasanth ; Thabut, Dominique ; Goria, Odile ; Dajti, Elton ; Berzigotti, Annalisa ; Reiberger, Thomas ; Plessier, Aurélie ; Schepis, Filippo

Background and Aims:Baveno VII consensus suggests that screening endoscopy can be spared in patients with compensated cirrhosis when spleen stiffness measurement (SSM) by vibration-controlled transient elastography (VCTE) is ≤40 kPa as they have a low probability of high-risk varices (HRV). Conversely, screening endoscopy is required in all patients with porto-sinusoidal vascular disorder (PSVD). This study aimed to evaluate the performance of SSM-VCTE to rule out HRV in patients with PSVD and signs of portal hypertension.Approach and Results:We retrospectively included patients with PSVD, ≥1 sign of portal hypertension, without a history of variceal bleeding, who underwent an SSM-VCTE within 2 years before or after an upper endoscopy in 21 VALDIG centers, divided into a derivation and a validation cohort. One hundred fifty-four patients were included in the derivation cohort; 43% had HRV. By multivariable logistic regression analysis, SSM-VCTE >40 kPa and serum bilirubin ≥1 mg/dL were associated with HRV. SSM-VCTE ≤40 kPa combined with bilirubin <1 mg/dL had a sensitivity of 96% to rule out HRV and could spare 38% of screening endoscopies, with 4% of HRV missed, and a 95% negative predictive value. In the validation cohort, including 155 patients, SSM combined with bilirubin could spare 21% of screening endoscopies, with 4% of HRV missed and a 94% negative predictive value.Conclusions:This study gathering a total of 309 patients with PSVD showed that SSM-VCTE ≤40 kPa combined with bilirubin <1 mg/dL identifies patients with PSVD and portal hypertension with a probability of HRV <5%, in whom screening endoscopy can be spared.

2025-02-01·International Journal of Infectious Diseases

Evolution of pharmacist roles in antimicrobial stewardship: A 20-year systematic review

Review

作者: Charani, Esmita ; Mohamed, Zubair Umer ; Nampoothiri, Vrinda ; Hisham, Mohamed ; Mbamalu, Oluchi ; Singh, Sanjeev K

INTRODUCTIONWhilst pharmacists are recognized as key contributors to antimicrobial stewardship (AMS) programs, the extent of their participation varies in different countries. We report a systematic review of pharmacist roles in AMS over 20 years.METHODSA systematic review of the literature describing pharmacist-led or driven AMS and its outcomes published in English between January 01, 2000, and June 30, 2020, was conducted across the main databases for research publication.RESULTSThe analysis included 111 papers, of which 77.5% (86/111) were from high-income countries (HIC) predominantly from the USA. While pharmacist-led or driven AMS interventions were reported only from HICs in the early 2000s, the review found a progressive rise in such studies from all income settings with audit and feedback being the most frequent intervention reported. Between 2016 and 2020, studies on pharmacists-led or driven outpatient AMS and interventions related to beta-lactam or penicillin allergy were reported from HICs. Key outcomes reported include improved appropriateness of antimicrobial therapy and decreased consumption of antimicrobials.CONCLUSIONExisting evidence demonstrates the positive impact of pharmacists' involvement in AMS. There needs to be a concerted effort in facilitating pharmacist roles in AMS across all countries, irrespective of income setting.

2025-02-01·Indian Journal of Thoracic and Cardiovascular Surgery

Long-term outcomes of women compared to men after off-pump coronary artery bypass grafting—a propensity-matched analysis

Article

作者: Jose, Rajesh ; Anwar, Anees ; Subash, Varshini ; Varma, Praveen Kerala ; Krishna, Neethu ; Gopal, Kirun ; Radhakrishnan, Rohik Micka ; Sukumaran, Sheejamol Velickakathu

BackgroundLiterature is not clear whether women experience increased mortality and adverse events after coronary artery bypass grafting (CABG). Studies have shown that women had comparative outcomes to men in off-pump CABG (OPCAB). Hence, we undertook this study to understand the short- and long-term outcomes of women compared to men after OPCAB.MethodsTwo thousand two hundred patients who underwent OPCAB from November 2014 to December 2021 were included in the study. Median follow-up period was 4.8 years. We performed propensity matching to match 404 women to 404 men.ResultsIn the unmatched cohort, women had increased cardiovascular mortality and inferior major adverse cardiovascular and cerebral event (MACCE)-free survival. In the matched cohorts, there was no difference in the 30-day mortality, long-term survival, MACCE-free survival, and cardiovascular mortality between the sexes. Cox proportional hazard showed post-operative renal failure (p-value < 0.001; hazard ratio (HR) 11.469) (confidence interval (CI) 2.911-45.180), post-operative stroke (p-value 0.023, HR 6.473) (CI 1.295-32.356), EuroSCORE II > 6 (p-value 0.022, HR 3.561) (1.204-10.531), emergency surgery (p-value 0.022, HR 3.498) (CI 1.202-10.177), and ventilation hours (p-value 0.004, HR 3.327) (CI 1.455-7.607) were the risk factors associated with long-term mortality in women.ConclusionOur study showed that the increased risk profile of women was the reason for inferior MACCE-free survival and increased cardiovascular mortality in women in the long term after OPCAB. When the risk factors were matched, women had comparable outcomes to men.Graphical Abstract

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100 项与 Amrita Institute of Medical Sciences 相关的转化医学

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