2-(4-Bromomethylphenyl) propionic acid (5), the key intermediate of loxoprofen sodium, was synthesized from phenylacetonitrile by methylation, hydrolysis and bromomethylation with an overall yield of 53.2%. The bromomethylation had not been found in literature. Loxoprofen sodium was obtained from 5 by esterification, condensation, hydrolyzation, and salt formation with an overall yield of 40% (based on phenylacetonitrile) and a purity of 99.8%. This process had the advantages of easily available starting materials, simple procedures, relatively steady yield, and was suitable for scale-up production