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Martin Oft, M.D., assumes role of Chief Scientific Officer Greg Yedinak promoted to Chief Technical Officer MENLO PARK, Calif.--(BUSINESS WIRE)-- Synthekine Inc., an engineered cytokine therapeutics company, today announced the appointment of Geoff Nosrati, Ph.D., as chief business officer. The company also announced additional changes in the executive leadership team, with Martin Oft, M.D., assuming the role of chief scientific officer and Greg Yedinak promoted to chief technical officer. “Geoff is an accomplished biotechnology executive with extensive knowledge in corporate strategy and business development,” said Debanjan Ray, chief executive officer of Synthekine. “His experience in portfolio strategy and transactions will be an asset to Synthekine as we continue to advance our wholly owned pipeline and progress our partnering activities.” Ray continued, “We’re also delighted to recognize Martin and Greg’s contributions to Synthekine with their new roles. Martin’s deep insights into cytokine biology and immunology were instrumental to shaping the development of STK-012, our first-in-class alpha/beta biased IL-2. Its unique mechanism expands the therapeutic index of IL-2, one of the most important immuno-oncology targets, providing improved efficacy while avoiding IL-2 related vascular toxicities. Greg’s broad expertise in the development and manufacturing of biologics and cell therapies has allowed us to advance both STK-012 and STK-009 + SYNCAR-001, our novel combination therapy of orthogonal IL-2 and CD19 CAR-T with potential to overcome limitations of current CD19 directed cell therapies in both hematological malignancies and autoimmune disease, into clinical development. Their contributions over the years have been invaluable to Synthekine’s rapid progress.” Dr. Nosrati is an expert in corporate strategy and business development with more than 20 years of experience in the biotechnology industry. He has worked across multiple modalities and therapeutic areas, with an emphasis on oncology, autoimmune and rare disease. Prior to joining Synthekine, Dr. Nosrati was chief business officer at Nutcracker Therapeutics. In his previous experience, he also served as chief business officer of ImmunoScape and held multiple senior executive roles at Aduro Biotech. In these positions, he worked closely with research, development, and commercial teams to strategically position the companies in the market and establish them as preferred partners for leading pharmaceutical and biotechnology organizations. Early in his career, Dr. Nosrati advised pharmaceutical and biotechnology clients at McKinsey & Co., with a focus on corporate strategy, finance, due diligence, and mergers and acquisitions. Dr. Nosrati holds a Ph.D. in Biochemistry and Molecular Biology from the University of California, Los Angeles and graduated with a B.S. in Chemistry from Duke University. Dr. Oft joined Synthekine at its formation in 2019 and previously served as the chief development officer. He is an expert in immune therapies, with in-depth experience in preclinical, translational, and clinical research and development of cytokine therapeutics for cancer and inflammatory disease. Prior to Synthekine, Dr. Oft co-founded ARMO Biosciences, where he oversaw pipeline development including pegilodecakin (pegylated IL-10) from early-target discovery through phase 3 clinical studies. He identified integrated immune-modulating strategies for the treatment of cancer, including the invigoration of tumor-specific T-cell immunity concomitant with inhibition of tumor-promoting inflammation. Prior to ARMO, Dr. Oft developed immune therapies for the treatment of cancer at DNAX Research in Palo Alto, now Merck Research Labs, and held positions at Onyx Pharmaceuticals, the UCSF Cancer Center and Boehringer Ingelheim. Dr. Oft earned his M.D. and medical license from the University of Erlangen, Germany. He performed his postdoctoral research at the Institute of Molecular Pathology in Vienna, Austria. Mr. Yedinak previously served as senior vice president of technical operations after joining the company in 2020. He has more than 30 years of experience in pharmaceutical, biologics, and medical device process development, manufacturing and operations. Prior to joining Synthekine, Greg was senior vice president of manufacturing and supply chain operations at PACT Pharma, where he was responsible for building the internal and CMO manufacturing operations for the PACT Pharma cell therapy programs. Prior to PACT Pharma, he held various executive and leadership positions at Versatis, Zosano, Nuvelo, Abgenix/Amgen and Genentech, where he was integral to the strategic production planning, process development, and production of numerous clinical and commercial products and devices. Greg earned a B.S. in biological sciences from the University of California-Irvine. About Synthekine Synthekine is harnessing the potential of cytokine therapeutics to develop selective immunotherapies designed to improve the treatment paradigm of cancer and inflammatory disease. Using insights on cytokine structure and function, the company engineers therapeutics designed to unlock the full efficacy potential of cytokines while avoiding their associated toxicities. Synthekine is applying principles of cytokine partial agonism and immunological specificity across multiple protein engineering platforms to create a broad and deep pipeline of product candidates. These novel immunotherapies include modified cytokines, cytokine-enhanced cell therapies and surrogate cytokine agonists. For more information, visit , and follow us on Twitter @synthekine and LinkedIn. View source version on businesswire.com: Contacts Will Zasadny Inizio Evoke Comms 619-961-8848 will.zasadny@inizioevoke.com Source: Synthekine Inc. View this news release online at:

SOUTH SAN FRANCISCO, Calif.--( BUSINESS WIRE )--Switch Therapeutics, a biotechnology company pioneering a new way to use RNA science to treat diseases utilizing its proprietary CASi (Conditionally Activated siRNA) platform, today announced the appointment of Charles Allerson, Ph.D., as Chief Technology Officer (CTO). He succeeds Si-ping Han, Ph.D., co-founder of Switch Therapeutics, who will transition to an advisory role and serve on Switch’s Scientific Advisory Board. “ Charles joins our leadership team with extensive expertise in oligonucleotide chemistry and RNA-based therapeutics, and we are delighted to welcome him to Switch. He will play a crucial role as we continue driving our novel CASi platform forward for the treatment of central nervous system (CNS) diseases,” said Dee Datta, Ph.D., co-founder and CEO of Switch Therapeutics. “ We also want to thank Dr. Han for his significant impact at Switch by leading the invention of the CASi platform, where efficient self-delivery, uptake and potency have been demonstrated in vivo . We look forward to his continued contributions as he joins our Scientific Advisory Board – a team of esteemed leaders in drug discovery, RNA science and CNS research – and are excited for what’s ahead in 2024.” Dr. Allerson joins Switch Therapeutics after dedicating more than 20 years of his career building nucleic acid chemical tools and applying them to the development of RNA-based therapeutics. Most recently, he served as Senior Vice President of Chemistry at DTx Pharma from 2019 until its acquisition by Novartis in 2023. Dr. Allerson led efforts to develop the FALCON platform for the extrahepatic delivery of RNA therapeutics and to translate this platform into a portfolio of preclinical assets. Dr. Allerson began his career as a chemist at Variagenics, and subsequently joined the Medicinal Chemistry team at Isis (now Ionis) Pharmaceuticals. Following his role at Ionis, he led early-stage and development stage chemistry at Regulus Therapeutics, and subsequently joined Stoke Therapeutics as Vice President of Chemistry where he helped prepare the company’s TANGO platform for the clinic. Dr. Allerson earned his B.S. in Chemistry from Lafayette College, his Ph.D. in Chemistry from Harvard University, and spent several years as a postdoctoral fellow at the National Institutes of Health prior to his move into industry. “ I am thrilled to join Switch at this pivotal time and look forward to partnering with my new colleagues to advance CASi into the clinic and beyond,” said Dr. Allerson, Ph.D. “ The three-stranded structures of CASi provide an opportunity to deploy novel chemistry and design strategies that will create unique medicines and open new therapeutic target spaces. I am eager to continue the innovation of the CASi platform, enabling Switch to translate the power of RNA science into a new generation of RNA medicines.” About Switch Therapeutics Switch Therapeutics is an emerging biotechnology company pioneering a new type of medicine that integrates nucleic acid nanotechnology and RNA interference (RNAi) science, with the goal of treating a range of diseases – affecting the central nervous system, peripheral nervous system and systemic indications – with significant unmet need. The company’s proprietary, three stranded RNA platform named CASi (Conditionally Activated siRNA), is based on technology developed by renowned researchers in the field of RNA and drug development from Caltech, Harvard Medical School and City of Hope. CASi combines advantageous properties of both single and double-stranded RNAs in a single molecule, allowing for improved biodistribution, functionality, efficacy and cell selective RNAi activity. Switch is based in South San Francisco, California. For more information, connect with Switch on LinkedIn or visit www.switchthera.com .

- Mr. Smith is a recognized leader in the commercialization of PAH products, most recently leading sotatercept US pre-launch activities at Merck - - Previously, Mr. Smith led US sales operations for Actelion - SAN DIEGO--(BUSINESS WIRE)-- Gossamer Bio, Inc. (Nasdaq: GOSS), a clinical-stage biopharmaceutical company focused on the development and commercialization of seralutinib for the treatment of pulmonary arterial hypertension (PAH), today announced the appointment of Bob Smith as its Chief Commercial Officer. “We are proud to welcome Bob Smith to the Gossamer team and his 30 years of expertise at this critical time in our company’s history,” said Faheem Hasnain, Chairman, Co-Founder and CEO of Gossamer Bio. “With Bob’s arrival, Gossamer is well-positioned to transition itself from a pre-commercial, clinical-stage biotechnology company to a fully integrated commercial organization focused on bringing seralutinib to patients with pulmonary hypertension. Given his distinguished experience as a senior commercial leader at both Merck and Actelion, and having launched significant PAH brands, we are confident that Bob is the best person for this key role, and we appreciate the confidence that such an accomplished commercial professional has shown in seralutinib by joining Gossamer Bio.” “I am excited to join the Gossamer Bio team at this pivotal time and to contribute to its mission to enhance the lives of patients living with pulmonary hypertension,” said Mr. Smith. “I believe that seralutinib has the potential to be a treatment paradigm-altering therapeutic in PAH. The mechanism of action, convenience, safety pro to date, and the possibility of reverse remodeling are all potential differentiators in a life-threatening disease with high unmet need. I look forward to getting this important and needed treatment to patients.” Mr. Smith has over 30 years of experience in pharmaceuticals, with a strong focus on PAH and rare disease. Since January 2023, Mr. Smith has been the National Sales Lead in charge of preparing for the potential launch of sotatercept for the treatment of PAH in the US at Merck & Co. Prior to this, Mr. Smith was the President of LTM Pharma Consulting, where he helped build strategic brand, launch and organization plans for pre-commercial rare disease companies. Previously, until 2018, Mr. Smith was the Senior Vice President of Sales and Executive Leadership Team member at Actelion, where he spent more than eleven years in various senior commercial leadership roles. As the principal sales leader, Mr. Smith managed all U.S. sales operations, including sales, training, sales operations, patient & professional advocacy, key customer engagement and territory management. Mr. Smith spearheaded two successful blockbuster PAH drug launches, OPSUMIT and UPTRAVI, which ultimately led to the purchase of Actelion by Johnson & Johnson in 2017 for $30 billion. Before joining Actelion, Mr. Smith held various pharmaceutical marketing and sales leadership roles, with a focus on cardiovascular franchises, at Nuvelo, Johnson & Johnson, and Bristol-Myers Squibb. Mr. Smith received a B.B.A. in Marketing from Texas A&M University. About Gossamer Bio Gossamer Bio is a clinical-stage biopharmaceutical company focused on the development and commercialization of seralutinib for the treatment of pulmonary arterial hypertension. Its goal is to be an industry leader in, and to enhance the lives of patients living with, pulmonary hypertension. Forward-Looking Statements Gossamer cautions you that statements contained in this press release regarding matters that are not historical facts are forward-looking statements. These statements are based on the Company’s current beliefs and expectations. Such forward-looking statements include, but are not limited to, statements regarding: the expected transition to a commercial organization and the potential differentiators of seralutinib to patients. The inclusion of forward-looking statements should not be regarded as a representation by Gossamer that any of its plans will be achieved. Actual results may differ from those set forth in this press release due to the risks and uncertainties inherent in Gossamer’s business, including, without limitation: potential delays in the commencement, enrollment and completion of clinical trials; disruption to our operations from the COVID-19 pandemic, including clinical trial delays; the Company’s dependence on third parties in connection with product manufacturing, research and preclinical and clinical testing; the results of preclinical studies and early clinical trials are not necessarily predictive of future results; the success of Gossamer’s clinical trials and preclinical studies for seralutinib; regulatory developments in the United States and foreign countries; unexpected adverse side effects or inadequate efficacy of seralutinib that may limit their development, regulatory approval and/or commercialization, or may result in clinical holds, recalls or product liability claims; Gossamer’s ability to obtain and maintain intellectual property protection for seralutinib; Gossamer’s ability to comply with its obligations in collaboration agreements with third parties or the agreements under which it licenses intellectual property rights from third parties; unstable market and economic conditions and adverse developments with respect to financial institutions and associated liquidity risk may adversely affect our business and financial condition and the broader economy and biotechnology industry; Gossamer may use its capital resources sooner than it expects; and other risks described in the Company’s prior press releases and the Company’s filings with the Securities and Exchange Commission (SEC), including under the heading “Risk Factors” in the Company’s annual report on Form 10-K and any subsequent filings with the SEC. You are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date hereof, and Gossamer undertakes no obligation to update such statements to reflect events that occur or circumstances that exist after the date hereof. All forward-looking statements are qualified in their entirety by this cautionary statement, which is made under the safe harbor provisions of the Private Securities Litigation Reform Act of 1995.