Delving into the Latest Updates on Universidad Autónoma De San Luis Potosí with Synapse

概览

疾病领域	数量

免疫系统疾病	1

排名前五的药物类型	数量

毒素	1

排名前五的靶点	数量

Kv1.3(电压门控性钾通道蛋白亚型Kv1.3)	1

关联

1

项与 Universidad Autónoma De San Luis Potosí 相关的药物

Vm24

靶点

Kv1.3

作用机制

Kv1.3阻滞剂

在研机构

Universidad Nacional Autónoma de México [+1]

原研机构

Universidad Nacional Autónoma de México

在研适应症

自身免疫性疾病 [+1]

非在研适应症-

最高研发阶段临床前

首次获批国家/地区-

首次获批日期-

48

项与 Universidad Autónoma De San Luis Potosí 相关的临床试验

NCT06598072

/ Completed临床3期

Clinical Study to Evaluate the Efficacy of a Regimen Including Rinsing With an Alcohol Free Mouthwash Containing CPC+Zn as Compared to Dental Flossing and Brushing and a Regimen Including Rising With an Essential Oils Containing Alcohol Mouthwash in Reducing Dental Plaque and Gingivitis.

This is a Phase III, randomized, one-center, parallel group, double blinded, clinical study to evaluate the efficacy of an alcohol-free mouthwash containing CPC+Zn as compared to dental flossing and to rising with an essential oils containing alcohol mouthwash in reducing dental plaque and gingivitis. One hundred and twenty participants, aged between 18 and 65 years, will be included and followed for 12 weeks.

开始日期2024-09-17

申办/合作机构

Colgate-Palmolive Co.

[+1]

NCT06528964

/ RecruitingN/A

Expression of Proteinopathies in Skin Biopsies of Patients With Neurodegenerative Disorders

The goal of this observational study is to compare the aggregation pattern of proteinopathies (alpha-synuclein, amyloid-beta, phosphorylated tau and transactive response DNA -binding protein 43 [TDP43]) in skin biopsies of patients with a neurodegenerative disease like Alzheimer's disease, frontotemporal lobe dementia, Parkinson's disease, atypical Parkinsonism, amyotrophic lateral sclerosis or normal pressure hydrocephalus. The main question it aims to answer is:
* Is there a specific pattern of aggregation of proteinopathies in skin biopsies in each neurodegenerative disease in comparison to healthy control subjects?
Skin biopsies will be analyzed using immunohistochemistry and immunofluorescence for detection of alpha-synuclein, amyloid-beta, phosphorylated tau and TAR DNA binding protein 43, and the aggregation patterns will be compared between patients with a neurodegenerative disease vs patient with normal pressure hydrocephalus vs healthy control subjects.

开始日期2023-12-20

申办/合作机构

Universidad Autónoma De San Luis Potosí

NCT06234839

/ CompletedN/A

Efficacy of Two Orally Administered Lactobacillus Reuteri Strains for Gingivitis Reduction in Young Adults: A Randomized Controlled Clinical Trial

The aim of the present study was to investigate the potential beneficial effects in volunteer young adults of orally administered L. reuteri (DSM 17938 and ATCC PTA 5289) on gingival inflammation. The null hypothesis was that no difference would be manifested by probiotic therapy regarding the conventional mechanical treatment (without probiotic administration).

开始日期2023-01-07

申办/合作机构

Universidad Autónoma De San Luis Potosí

100 项与 Universidad Autónoma De San Luis Potosí 相关的临床结果

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0 项与 Universidad Autónoma De San Luis Potosí 相关的专利（医药）

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10,669

项与 Universidad Autónoma De San Luis Potosí 相关的文献（医药）

2025-08-01·Colloids and Surfaces B: Biointerfaces

Solar-driven photochemical synthesis of bismuth-naringin nanoparticles with anticancer properties

Article

作者: Salado-Leza, Daniela ; Estrada-Loredo, Sarahí Josefina ; Rodríguez-Chávez, Victoria Nephertiti ; Meza-Pardo, Ingrid Guadalupe ; Castillo-Rivera, Francisco ; Silva-Melgarejo, Fernanda Abigail ; Sánchez-Campos, Daniel

Bismuth-naringin (BiNar) nanoparticles were developed using a straightforward sunlight-assisted photochemical method to enhance the properties of naringin. The resulting BiNar colloid consists in semi-spherical particles of approximately 30 nm in size with a negative surface charge. Complexation was elucidated using various spectrometric techniques. The anticancer properties of both naringin and the nanoparticles were evaluated by performing MTT colorimetric assays in human cervical cancer cells. BiNar significantly reduced the viability of cancer cells, underscoring its therapeutic potential.

2025-07-01·Separation and Purification Technology

Energy-economic purification of n-hexane from low benzene concentrations via extractive distillation with propylene carbonate as solvent: A comparative study with liquid–liquid extraction processes

作者: Barajas-Villarruel, Luis R. ; Cruz Valdez, Jesus Alonso ; Patino-Herrera, Rosalba ; Aviles Martinez, Adriana ; Perez, Elias

n-Hexane is one of the most widely used products in the petrochem. industry, where regulatory toxicol. policies require benzene content to be < 100 ppm in polymer-grade n-hexane.The n-hexane/benzene mixture forms a homogeneous azeotrope, making its separation challenging.This study focuses on the purification of an n-hexane/benzene mixture with a benzene concentration of 10 mol%, as no established methodol. exists for the purification of mixtures with aromatic concentrations below 20 mol%.Extractive distillation (ED) and liquid-liquid extraction-extractive distillation (LLEx-ED) processes using propylene carbonate (PC) and ethylene carbonate (EC) as solvents are proposed as alternatives to sulfolane (SF) and liquid-liquid extraction (LLEx) processes.According to simulations in Aspen Plus V9, using PC in ED processes allows for obtaining n-hexane with a concentration of 99.99 mol% with benzene impurities of 66.81 ppm, while benzene is obtained at a purity of 99.91 mol%.This approach results in energy savings of 42.90 %, a 22.62 % reduction in the Total Annual Cost (TAC), and a 54.77 % decrease in CO₂ emissions compared to the use of SF in conventional LLEx processes.Compared to LLEx-ED processes using EC, the use of PC in ED processes results in energy and CO₂ emission savings of 50.06 % and 60.50 %, resp.The results demonstrate the high efficiency of using PC in ED processes for separating systems with low aromatic content.

2025-06-01·Leukemia Research

Identification of ZNF384 as a regulator of epigenome in leukemia

Article

作者: Ávila-López, Pedro A ; Martínez, Yamelie A ; Rojas, Francisco I Torres ; Ortíz-Ortíz, Julio ; Vargas, Laura C Zárraga ; Viguri, Gabriela E Campos

Leukemia is a complex hematologic cancer driven by genetic and epigenetic changes that impact gene expression. Understanding these molecular mechanisms is essential for improving leukemia diagnosis and prognosis. This study examines the role of the zinc finger protein ZNF384 in the epigenome and its influence on gene regulation in leukemia. We analyzed next-generation sequencing data from The Encyclopedia of DNA Elements (ENCODE), integrating datasets such as chromatin immunoprecipitation sequencing (ChIP-seq) of ZNF384 and regulatory histone marks, RNA sequencing (RNA-seq), and Hi-C data from K562 and GM12878 cells. Additionally, we used RNA-seq from K562 ZNF384 knock-down (KD) cells generated via CRISPR interference (CRISPRi) to validate our findings. This enabled us to explore the chromatin interaction patterns of ZNF384 and its regulatory impact. Our results demonstrate that ZNF384 associates with promoters and enhancers in K562 and GM12878 cells, facilitating increased transcription levels. We also found ZNF384 enriched at topologically associating domain (TAD) boundaries and chromatin loops, suggesting a role in three-dimensional (3D) chromatin organization. Furthermore, we identified a significant binding of ZNF384 at SINE-Alu elements in both K562 and GM12878 cells. In summary, this study highlights the regulatory role of ZNF384 in the leukemia epigenome and its impact on gene expression. Understanding the oncogenic implications of ZNF384 may improve leukemia diagnosis and prognosis.

100 项与 Universidad Autónoma De San Luis Potosí 相关的药物交易

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100 项与 Universidad Autónoma De San Luis Potosí 相关的转化医学

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