Study to asess the effects of Iberogast® (STW5) and Iberogast® N (STW5-II) in intestinal gas transit and abdominal symptoms of patients suffering from irritable bowel syndrome or functional dyspepsia.

开始日期2020-09-03

申办/合作机构

Bayer Hispania SL

100 项与 Bayer Hispania SL 相关的临床结果

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0 项与 Bayer Hispania SL 相关的专利（医药）

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项与 Bayer Hispania SL 相关的文献（医药）

2018-07-01·Medicina Clínica4区 · 医学

Seguimiento de las recomendaciones del Informe de Posicionamiento Terapéutico sobre el tratamiento con anticoagulantes orales en pacientes ancianos con fibrilación auricular. Estudio ESPARTA

4区 · 医学

Article

作者: Cantero Hinojosa, Jesus ; Mostaza, Jose María ; Acosta de Bilbao, Fernando ; Cazorla, Daniel ; Suárez Fernández, Carmen ; Tamarit, Juan José ; Hernandez, Jose Luis ; Castilla Guerra, Luis ; Ràfols, Carles ; Suriñach, Josep Maria ; Diaz Diaz, José Luis

BACKGROUND AND OBJECTIVETo evaluate the adherence to the recommendations in clinical practice performed by the Therapeutic Positioning Report (TPR) of the Spanish Agency of Medicines and Sanitary Products about the treatment with oral anticoagulants in patients aged≥75 years old with nonvalvular atrial fibrillation (NVAF) treated in Internal Medicine departments in Spain.PATIENTS AND METHODSObservational, cross-sectional and multicenter study in which 837 patients aged≥75 years old with NVAF, with stable treatment with oral anticoagulants at least 3 months before inclusion, and that had started treatment with oral anticoagulants before the inclusion period were included.RESULTSMean age was 83.0±5.0 years old, mean CHADS₂ score 3.2±1.2, mean CHA₂DS₂-VASc score 5.0±1.4, and mean HAS-BLED score 2.1±0.9. A percentage of 70.8 of patients were treated with vitamin K antagonists (VKA) and the rest of patients with direct oral anticoagulants (DOACs). A percentage of 65.6 of patients treated with VKA did not follow the recommendations made by the TPR compared with 43.0% of patients treated with DOACs (P<.0001). In the case of VKA, the main reason for being considered as not appropriate according to the TPR was having poor control of anticoagulation and not switching to DOACs, whereas in the case of DOACs, it was not receiving the adequate dose according to the TPR.CONCLUSIONSIn a high proportion of anticoagulated elderly patients with NVAF in Spain, the recommendations performed by the TPR are not followed, particularly with VKA, since patients are not switched to DOACs despite time in therapeutic range.

2016-01-01·Medicina Clínica4区 · 医学

Estudio de factores pronósticos y de la prevalencia del síndrome postrombótico en España en pacientes con trombosis venosa profunda

4区 · 医学

Article

作者: Marín, Núria ; Camacho, Isabel ; Acosta, Fernando ; Salmerón, Luis ; Ordi, Josep

BACKGROUND AND OBJECTIVEThe prevalence of post-thrombotic syndrome (PTS) in Spain is not known accurately at present. The main objective of this study was to determine the prevalence of PTS and the possible prognostic factors related to its development and impact on quality of life.PATIENTS AND METHODThis was an observational, multicenter, cross-sectional and retrospective study of patients who had suffered a deep vein thrombosis (DVT) between March 2010 and March 2011. The Villalta scale was applied as a standardized assessment of PTS at the enrollment visit. According to the score, distribution was: patients with PTS (score>4) and patients without PTS (score ≤4). Subsequently, DVT data and risk factors were collected retrospectively. The quality of life of patients was evaluated.RESULTSIn total 511 patients with DVT were enrolled, of which 7 patients were excluded as they did not meet the inclusion/exclusion criteria. The prevalence of PTS was 53%, with 56.2% having a mild character, 20.6% moderate, and 23.2% severe. The presence of risk factors for DVT including immobilization, hormonal therapy and obesity was significantly higher in patients with PTS than in patients without PTS. There were not significant differences in the location of the DVT. The perception of patients about their health was significantly worse in patients with DVT.CONCLUSIONSThe prevalence of PTS in patients with DVT is very high. The presence of risk factors for DVT clearly contributes to a greater predisposition to suffering PTS in an average time of 2 years.

Cosmetics

Two New Dexpanthenol-Containing Wash Gels: Skin Hydration, Barrier Function, and Cosmetic Performance Upon Single and Repeated Usage in Subjects with Dry Skin

作者: Nanu, Elena Alina ; Trapp, Sonja ; Dumitru, Veronica ; Stettler, Hans ; Olsavszky, Rozalia ; de Salvo, Raffaella ; Dopcea, Ioan ; Barrionuevo-Gonzalez, Ana

Two novel body/face wash gels enriched with emollient ingredients (including dexpanthenol) were developed for the daily care of dry skin. Two similarly designed 2-week studies (N = 42 each) were conducted to assess the biophysical and cosmetic performance of each of the new wash gels in healthy adults with dry skin. Instrumental measurements quantified the effects of the wash gels on stratum corneum (SC) hydration and transepidermal water loss (TEWL) (with and without a previous sodium lauryl sulfate (SLS) challenge) after single and repeated usage. Following single and repeated applications of the face wash gel to facial skin, as well as to dry SLS-undamaged and SLS-damaged skin of the forearm, skin hydration significantly increased. Similarly, after single and repeated usage of the body wash gel to dry SLS-undamaged and SLS-damaged skin of the forearm, skin moisturization increased significantly from baseline; comparisons with control areas provided inconsistent results for SLS-undamaged skin. No effects on TEWL were observed for either product. Both wash gels were well tolerated and the cosmetic performances were appreciated by the subjects. The study results suggest that daily use of the new wash gels was associated with significant skin-moisturizing effects without adversely affecting skin barrier function and repair.

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100 项与 Bayer Hispania SL 相关的转化医学

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