Prophylactic Effects of Different Duration of Intravenous Ampicillin for Preventing Surgical Site Infection in Third Molar Surgery: a Randomized Controlled Trial

The purpose of this study is to determine the incidence of surgical site infection (SSIs) after third molar surgery for different duration of intravenous ampicillin administration.

开始日期2024-05-02

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Uji Hospital

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2021-02-01·General Thoracic and Cardiovascular Surgery4区 · 医学

Long-term results of the maze procedure with GP ablation for permanent atrial fibrillation

4区 · 医学

Article

作者: Fujita, Masatoshi ; Iwakura, Atsushi ; Nishina, Takeshi ; Yamanaka, Kazuo

OBJECTIVESWe investigated the effect of the maze procedure with intensive pulmonary vein isolation (PVI) guided by ganglionated plexus (GP) mapping (the Maze with GP ablation group) on a long-term postoperative maintenance of sinus rhythm in patients with permanent atrial fibrillation (AF) and compared with that in patients undergoing the maze procedure with the conventional PVI (the Maze group).METHODS AND RESULTSWe investigated 48 patients who underwent the maze procedure with GP ablation for persistent AF and 43 patients who underwent the maze procedure. The Maze procedure was conducted by the endocardial application of bipolar radiofrequency ablation and cryoablation. Conventional PVI was applied three times for the entrance of right and left PVs, respectively. Intensive PVI for GP ablation was repeated six-to-eight times for both sides of PVs to cover the bilateral GP regions identified by GP mapping. The duration of permanent AF, the prevalence of concomitant primary heart diseases, and the postoperative follow-up period were comparable between the two groups. At discharge, 1 year, 5 years after the surgery, sinus rhythm was maintained in 74.4%, 61%, and 40.5% of the Maze group. In contrast, it was maintained in 93.7%, 88.9%, and 75.7% of the Maze with GP ablation group. The cumulative freedom rate from AF at 10 years after surgery was significantly higher in the Maze with GP ablation group.CONCLUSIONSMore intense PV isolation including adjacent GP may improve long-term results of maze procedure in patients with permanent AF.

2020-11-01·Internal Medicine4区 · 医学

Adult-onset Repeat Rhabdomyolysis with a Very Long-chain Acyl-CoA Dehydrogenase Deficiency Due to Compound Heterozygous <i>ACADVL</i> Mutations

4区 · 医学

Article

作者: Yamashita, Hirofumi ; Saito, Yoshihiko ; Sugie, Hideo ; Nishino, Ichizo ; Fuseya, Yasuhiro ; Fukuda, Tokiko ; Sato, Kei ; Kaji, Seiji ; Miyahara, Jun-ichi ; Sakurai, Takeyo ; Takahashi, Makio

Very long-chain acyl-CoA dehydrogenase (VLCAD) deficiency is a genetic disorder of fatty acid beta oxidation that is caused by a defect in ACADVL, which encodes VLCAD. The clinical presentation of VLCAD deficiency is heterogeneous, and either a delayed diagnosis or a misdiagnosis may sometimes occur. We herein describe a difficult-to-diagnose case of the muscle form of adult-onset VLCAD deficiency with compound heterozygous ACADVL mutations including c.790A>G (p.K264E) and c.1246G>A (p.A416T).

2020-10-05·BUNSEKI KAGAKU

Recent Advances in ICP-MS Analysis for Metallomics Research of Heart and Kidney Diseases

作者: SHIRATAKI, Junko ; FUJISAKI, Kazuyuki ; SATO, Nobuyuki ; IIDA, Yutaka ; ICHINOSE, Takayuki ; NAKAYAMA, Akihiro ; HIRAOKA, Yuji

Metallomics is an omics study for the purpose of ubiquitously understanding the function and role of trace elements in biol. activity.In this report, we introduce two topics of anal. techniques related to metallomics studies.ICP-MS have been widely used for the anal. of trace elements, but spectral interference problems sometimes prevent sensitive and accurate anal.Although various methods had been invented to overcome the problems, the authors developed a simultaneous anal. method for the quantification of trace elements in blood by using sector-field ICP-MS which is more reliable in avoiding polyat. interferences.We analyzed 25 elements in the human serum of patients with heart or kidney disease and healthy persons using the developed method, and examined the relationship between trace elements and those diseases by using multivariate data anal.The results showed serum Se and Mn correlated strongly and those concentrations in heart disease patients were significantly lower than those in healthy persons.In particular, the selenium concentration showed a strong relationship with a cardiac function, such as a left ventricular ejection fraction.On the other hand, serum Cr, Ni, and Mo concentrations were significantly higher in dialysis patients.As described above, our study suggests that the kinetics of the trace elements may be causally related to disease conditions.Secondly, ICP-MS can obtain the positional distribution of trace elements in an anal. sample by combining with a laser ablation technique.Hence, we have also tried to develop a LA-ICP-MS imaging technique for biol. samples.The trace-element distributions of a human hair strand and a mouse tissue section could be successfully obtained by one or two-dimensional LA-ICP-MS imaging.Furthermore, a multiplex bio-imaging was also obtained by staining with metal-tagged antibodies.Recent developments in ICP-MS and laser ablation techniques are also described along with the above two topics.

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