The goal of this in vitro study is to compare the marginal fit and internal adaptation of all-metal crowns in polished crown preparations and non-polished crown preparations The main question it aims to answer is: are the non polished tooth preparations comparable to polished preparations? We will compare polish and non polish groups and see their effects on marginal fit and internal adaptation of all metal crown

开始日期2024-03-01

申办/合作机构

Altamash Institute of Dental Medicine

NCT06074952

/ RecruitingN/AIIT

Comparing the Color Stability of Acrylic Denture Teeth in Different Staining Solutions-In Vitro Experimental Trial

The purpose of this (In Vitro Experimental Trial) is to assess (the color stability of acrylic denture teeth) in( different staining solutions) at (time intervals).
The (acrylic denture) teeth will be immersed in (staining solutions) and the values will be recorded at (different time intervals).
Three groups will be made:
Group A- Control group
Group B- Study group
Group C- Study group

开始日期2023-10-01

申办/合作机构

Altamash Institute of Dental Medicine

NCT05883566

/ CompletedN/AIIT

Comparison of Behavioral , Physiological and Self-reported Pain Responses in Children With Dental Pain

Study involves the observation of the child's behavior during a dental treatment procedure. This allows for the evaluation of the child's experience of pain and discomfort through their facial expressions, body movements, and vocalizations during the procedure.

开始日期2023-05-01

申办/合作机构

Altamash Institute of Dental Medicine

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138

项与 Altamash Institute of Dental Medicine 相关的文献（医药）

2024-11-12·Circulation

Abstract 4139940: Safety and Efficacy of Self-Expanding vs Balloon-Expandable Valves for Transcatheter Aortic Valve Replacement in Patients with Aortic Stenosis: A Systematic Review and Real-World Meta-Analysis

作者: Hussain, Syed Anas ; Najeeb, Hala ; Kumar, Laksh ; Hotwani, Priya ; Saleem, Kashaf ; Habib, Hashir ; Kumar, Mukesh ; Devi, Priya ; Waheed, Mariyam ; Moeed, Abdul ; Siddiqui, Abdul Hannan ; alam, mahboob ; Mansoor, Javeria ; Hassan, Ahmed Bin

Background: There are two approved methods for transcatheter aortic valve replacement (TAVR) namely balloon-expandable valves (BEV) and self-expanding valves (SEV). While several randomized controlled trials (RCTs) have compared the efficacy of SEV and BEV, the generalizability of their findings is questioned. Therefore, to generate concrete evidence regarding the superiority between the two, we conducted this real-world meta-analysis to compare the clinical efficacy and safety outcomes of SEV vs BEV in patients undergoing TAVR for aortic stenosis (AS). Methods: MEDLINE, EMBASE, and Scopus were queried to shortlist studies including AS patients undergoing TAVR. Primary outcomes included 30-day and 1-year all-cause and cardiac mortality. Secondary outcomes were permanent pacemaker implantation (PPI), paravalvular leak (PVL), aortic regurgitation (AR), stroke, major vascular complications (MVC), major bleeding (MB), acute kidney injury (AKI), myocardial infarction (MI), length of stay (LOS), patient prosthesis mismatch (PPM), and atrial fibrillation (AF). A random effects meta-analysis was conducted to derive risk ratios and mean differences with corresponding 95% confidence intervals (CI). Results: Our meta-analysis included 38 real-world studies. No significant association was seen in 30-day (RR=1.13, P=0.15) and 1-year all-cause mortality (RR=1.04, P=0.55), and cardiac mortality (RR=1.28, P=0.12). SEV was associated with a higher risk of 30-day PPI (RR=1.61, 95% CI 1.28-2.02, I2 = 88%, P<0.0001), mild PVL (RR=1.52, 95% CI 1.17-1.97, I2=76%, P=0.002), and moderate to severe PVL (RR=1.97, 95% CI 1.43-2.72, I2=51%, P<0.0001). Patients in the SEV group experienced more statistically significant AR (RR=1.72, 95% CI 1.29-2.30, I2=27%, P=0.0002), and 30-day MVC (RR=1.1, 95% CI 1.02-1.2, I2=0%, P=0.02) when compared to the BEV group. No statistically significant association was established for stroke, MB, AKI, MI, LOS, PPM, and AF. Conclusion: Our real-world analysis showed that SEV increases the risk of PPI, PVL, AR, and MVC. However, all-cause and cardiovascular mortality were comparable between both groups. Our results confirm the conclusions drawn from RCTs, thus reassuring decision-makers that these findings can be extrapolated to real-world populations.

2024-10-01·European Journal of Orthodontics

Can vacuum-formed retainers maintain arch dimensions and alignment compared to Hawley and fixed bonded retainers after treatment with fixed appliances? A systematic review and meta-analysis

Review

作者: Kunwar, Sara Shahid ; Pandis, Nikolaos ; Khan, Umair Wali ; Alnazeh, Abdullah A ; Aziz, Anum ; Alam, Shamsul ; Campobasso, Alessandra ; Zaheen, Muhammad ; Kamran, Muhammad Abdullah ; Hussain, Umar

AbstractBackgroundDifferent types of retention appliances have been proposed over the years, but their effectiveness in maintaining arch dimensions and alignment after orthodontic treatment is still unclear.AimTo assess the efficacy of vacuum-formed retainers (VFRs) in preserving arch widths, arch length, and anterior alignment in maxillary and mandibular arches, compared to removable Hawley retainers (HRs) or fixed bonded retainers (FBRs). Search methods: unrestricted literature search of five major databases up to March 2024.Selection criteriarandomized/non-randomized clinical studies comparing VFRs to removable HRs or FBRs.Data collection and analysisafter duplicate study selection, data extraction, and risk of bias assessment, random effects meta-analyses of standardized mean differences and their 95% confidence intervals were performed, followed by meta-regressions, sensitivity analyses, and assessment of the quality of evidence with GRADE.ResultsTwenty-two prospective studies (4 non-randomized and 18 randomized controlled trials) involving 1797 patients (mean age 17.01 years, 38.3% males) were included. No significant differences were found in the intercanine width, intermolar width, and arch length between VFRs and HRs, in both arches (P > 0.05). However, VFRs were statistically more effective than HRs in terms of Little’s irregularity scores (LII) in the maxilla (eight studies; SMD = −0.42; 95% CI: −1.03 to −0.09; P = 0.02; I2 = 73.4%) but not in the mandible (P = 0.12). No significant differences were reported for all considered outcomes between VFRs and FBRs in in both arches (P > 0.05), except for lower LII, where VFRs were significantly less efficient (eight studies; SMD = 1.49; 95% CI = 0.26–2.7; P = 0.02; I2 = 93%). Follow-up times, risk of bias, and wire type (of FBRs) did not show statistically significant effects on outcome variables. Sensitivity analyses showed robustness of the findings for including non-randomized and postretention studies. The certainty in these estimates was from moderate to low due to the risk of bias and inconsistency.ConclusionsLow to moderate quality evidence indicates that VFRs are as effective as HRs in maintaining arch widths, length, and alignment. Low-quality evidence found similar efficacy between VFRs and FBRs, with FBRs being statistically more effective at maintaining lower arch alignment, but the difference was not clinically significant.RegistrationPROSPERO registration (CRD42024518433).

2024-10-01·Archives of Oral Biology

The association between genetic factors and temporomandibular disorders: A systematic literature review

Review

作者: Mosaddad, Seyed Ali ; Saini, Ravinder S ; Vyas, Rajesh ; Kanji, Masroor Ahmed ; Alshadidi, Abdulkhaliq Ali F ; Heboyan, Artak ; Alshahrani, Ahid Amer ; Binduhayyim, Rayan Ibrahim H ; Ahmed, Naseer ; Okshah, Abdulmajeed

OBJECTIVEThis study aimed to investigate the correlation between genetic factors and the occurrence and progression of temporomandibular disorders (TMDs) using a comprehensive review and meta-analysis.DESIGNA comprehensive search was conducted using the ScienceDirect, PubMed, Cochrane Library, Dimensions, and Emerald databases. A reviewer selected the study using modified PICO criteria, considering human subjects with TMDs, comparing different genetic factors among TMD and non-TMD patients, and reporting TMD signs and symptoms as outcomes. The methodological standards of the eligible papers were assessed using the Joanna Briggs Institute (JBI) Critical Appraisal Checklist for Non-randomized Experimental Investigations. Information was collected methodically and examined.RESULTSThe electronic database search yielded 851 articles, 19 of which were included in this study. The data analysis showed a significant influence of genetic factors, such as polymorphisms and gene differences, on the development of TMD signs and symptoms, such as myofascial pain, chronic pain, and disc displacement. In addition, gene polymorphism significantly influenced TMD development, with an odds ratio of 2.46 (1.93-3.14) and p of 0.00001.CONCLUSIONSGenetic factors significantly influenced TMD signs and symptoms, and genetic polymorphisms significantly influenced TMD onset and progression. Further research should be conducted in diverse settings with larger sample sizes to verify and validate these findings.

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