Effectiveness of a Modified Cost-Effective Dietary Plan in Promoting Weight Loss and Preservation of Lean Body Mass in Patients After Bariatric Surgery

This study will see if a low-cost dietary plan, based on the standard dietary guidelines of the American Society for Metabolic and Bariatric Surgery (ASMBS) and using locally available foods, can help patients lose weight and keep their lean body mass after bariatric surgery. It will also check if this plan can maintain healthy levels of important nutrients such as vitamin B12, iron, and vitamin D.
Patients who have undergone bariatric surgery will be randomly assigned to follow either the low-cost diet or the regular hospital diet. Their weight, body composition, and nutrient levels will be tracked at baseline, and at 1, 3, and 6 months after surgery.
The aim is to find out if this simpler, affordable diet, which follows international standards, works as well as the regular plan while being easier for low-income patients to follow.

开始日期2025-10-01

申办/合作机构

Khyber Teaching Hospital

NCT07096830

/ Not yet recruitingN/AIIT

Efficacy of Tetrachlorodecaoxide (TCDO) Drops in Chronic Wound Healing: Insights From a Randomized Controlled Trial

This is a single-center, randomized controlled trial evaluating the effectiveness of topical tetrachlorodecaoxide (TCDO) solution in enhancing chronic wound healing. The study will compare standard wound care with and without the addition of topical TCDO drops. Eligible adult participants with chronic wounds of more than six weeks' duration will be randomly assigned to either the intervention or control group. The trial aims to assess the rate of wound healing, time to 50% wound closure, pain reduction measured by the Visual Analog Scale (VAS), and cost-effectiveness.

开始日期2025-08-30

申办/合作机构

Khyber Teaching Hospital

NCT07090928

/ Not yet recruiting临床4期IIT

Effectiveness of Per-Operative Bupivicaine in Reducing Postoperative Pain at Port Site and Improving Mobility in Knee Arthoscopic Procedures

The investigator's aim is to evaluate the effectiveness of per-operative bupivacaine infiltration at arthroscopic port sites in reducing post-operative pain compared to placebo in patients undergoing knee arthroscopic procedures.

开始日期2025-08-01

申办/合作机构

Khyber Teaching Hospital

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项与 Khyber Teaching Hospital 相关的文献（医药）

2025-10-01·CURRENT MICROBIOLOGY

Comprehensive Molecular Profiling of AcrAB-TolC Efflux Pump Genes in Salmonella typhi Isolates from Typhoid Infected Patients

Article

作者: Alhegaili, Alaa S ; Ahmad, Aakash ; Ali, Sajid ; Muhammad ; Khalil, Atif Ali Khan ; Rehman, Noor ; Khan, Ibrar ; Azam, Sadiq

Salmonella typhi is a facultative anaerobic, rod-shaped, Gram-negative bacterium that causes typhoid fever, a potentially fatal systemic infection. This study aimed to characterize antibiotic susceptibility patterns, mutations at the molecular level, and efflux pump genes in clinical isolates. In this study, blood samples (n = 2950) were collected from suspected typhoid-infected patients, and 380 (12.88%) bacterial isolates were found, comprising 144 (37.89%) Gram-positive and 236 (62.10%) Gram-negative bacteria. S. typhi was identified in 95 isolates (25%), corresponding to an overall prevalence of 3.22%. Biochemical identification was performed by Analytical Profile Index (API) 20-E strips, and molecular identification was done by partial 16S rRNA gene using PCR. The S. typhi isolates were categorized into multidrug-resistant (MDR), 13 (13.68%), and extensively drug-resistant (XDR), 82 (86.31%), and their resistance patterns were recorded. Ampicillin (98.94%) and chloramphenicol (93.68%) showed the highest antibiotic resistance profiles, while azithromycin and meropenem exhibited no resistance. Numerous mutations were found in acrA, acrB, and tolC genes after sequencing; TolC (MDR) showed the highest score (16 points), and AcrB (MDR) displayed the lowest score (9 points). I-Mutant 2.0 was used to assess mutations and calculate the reliability index (RI), whereas trRosetta and Discovery Studio were used to predict and refine 3D protein models. Consensus sequences of the selected genes were analyzed to construct phylogenetic trees illustrating evolutionary relationships with other Salmonella enterica serovars. The study emphasizes the concerning multidrug resistance of S. typhi isolates as well as notable mutations (genetic changes) that may affect efflux pump activity and contribute to resistance.

2025-09-07·Journal of Robotic Surgery

Ensuring clinical translation of the Hernia ASCEND Hugo™ RAS training pathway: the need for outcome validation and anatomical accuracy.

Letter

作者: Rayyan, Syed Muhammad ; Saleem, Laraib ; Ghayur, Mahjabina S ; Amjad, Mehwish ; Haider, Noor-Ul-Eman

Journal of Robotic Surgery

Comment on “Subjective workload in operating room team members during robotic hernia procedures”

Letter

作者: Farhad, Abuzar ; Khan, Syed Huzaifa ; Khan, Hammad ; Ullah, Ubaid

项与 Khyber Teaching Hospital 相关的新闻（医药）

2025-01-02

·drugs

More Than Half of People With Rheumatoid Arthritis Have Anemia

THURSDAY, Jan. 2, 2025 -- Anemia is prevalent among patients with rheumatoid arthritis (RA), according to a study published online Oct. 26 in Cureus . Jamal Shah, M.B.B.S., from Khyber Teaching Hospital in Peshawar, Pakistan, and colleagues examined the prevalence of anemia among 330 patients with RA presenting at a tertiary care hospital in 2023. The researchers found that more than half of participants had anemia (54.55 percent). The mean hemoglobin level among these patients was 11.41 g/dL, and the red blood cell count averaged 4.26 million/µL. The Disease Activity Score was higher in patients with anemia (mean of 5.23 versus 4.98 in those without anemia). Most people with anemia had elevated C-reactive protein levels (83.33 percent; mean C-reactive protein, 28.79 mg/L) and an elevated erythrocyte sedimentation rate (88.89 percent; mean erythrocyte sedimentation rate, 45.17 mm/hour). There were significant associations observed between anemia and longer disease duration, higher RA severity, and increased inflammatory markers. "These findings underscore the critical importance of routine screening and management of anemia in RA patients, particularly those with severe or prolonged disease, as addressing anemia could enhance overall patient outcomes and quality of life," the authors write. "Future research should focus on elucidating the mechanisms linking RA and anemia, conducting longitudinal studies to better understand these associations over time, and evaluating the effectiveness of anemia treatments in improving patient health." Abstract/Full Text Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.

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