Effectiveness of a Modified Cost-Effective Dietary Plan in Promoting Weight Loss and Preservation of Lean Body Mass in Patients After Bariatric Surgery

This study will see if a low-cost dietary plan, based on the standard dietary guidelines of the American Society for Metabolic and Bariatric Surgery (ASMBS) and using locally available foods, can help patients lose weight and keep their lean body mass after bariatric surgery. It will also check if this plan can maintain healthy levels of important nutrients such as vitamin B12, iron, and vitamin D.
Patients who have undergone bariatric surgery will be randomly assigned to follow either the low-cost diet or the regular hospital diet. Their weight, body composition, and nutrient levels will be tracked at baseline, and at 1, 3, and 6 months after surgery.
The aim is to find out if this simpler, affordable diet, which follows international standards, works as well as the regular plan while being easier for low-income patients to follow.

开始日期2025-10-01

申办/合作机构

Khyber Teaching Hospital

NCT07096830

/ Not yet recruitingN/AIIT

Efficacy of Tetrachlorodecaoxide (TCDO) Drops in Chronic Wound Healing: Insights From a Randomized Controlled Trial

This is a single-center, randomized controlled trial evaluating the effectiveness of topical tetrachlorodecaoxide (TCDO) solution in enhancing chronic wound healing. The study will compare standard wound care with and without the addition of topical TCDO drops. Eligible adult participants with chronic wounds of more than six weeks' duration will be randomly assigned to either the intervention or control group. The trial aims to assess the rate of wound healing, time to 50% wound closure, pain reduction measured by the Visual Analog Scale (VAS), and cost-effectiveness.

开始日期2025-08-30

申办/合作机构

Khyber Teaching Hospital

NCT07090928

/ Not yet recruiting临床4期IIT

Effectiveness of Per-Operative Bupivicaine in Reducing Postoperative Pain at Port Site and Improving Mobility in Knee Arthoscopic Procedures

The investigator's aim is to evaluate the effectiveness of per-operative bupivacaine infiltration at arthroscopic port sites in reducing post-operative pain compared to placebo in patients undergoing knee arthroscopic procedures.

开始日期2025-08-01

申办/合作机构

Khyber Teaching Hospital

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项与 Khyber Teaching Hospital 相关的文献（医药）

2025-09-01·International journal of cardiology. Cardiovascular risk and prevention

Exploring the rising death rates among older US citizens with heart failure and sepsis: Need for health-care policy reform

Article

作者: Mamas, Mamas A ; Hall, Michael E ; Ahmed, Raheel ; Cortese, Bernardo ; Fatima, Eeshal ; Ahad, Abdul ; Ullah, Irfan ; Rehman, Obaid Ur ; Jamil, Adeena

Background:

Heart failure (HF) patients, often multimorbid and immunocompromised, are particularly vulnerable to sepsis, which increases their risk for mortality. It is therefore crucial to understand the mortality patterns in older adults (≥65) with HF and sepsis for improving care strategies in the United States.

Methods:

A cross-sectional evaluation of death certificates from the Centers for Disease Control and Prevention's Wide-Ranging Online Data for Epidemiologic Research (CDC WONDER) was conducted to examine HF and sepsis mortality trends. For demographic and geographic subgroups, age-adjusted mortality rates (AAMR) per 100,000 older individuals, alongside annual percent change (APC) in AAMR with 95 % confidence intervals (CI), were derived.

Results:

Throughout 1999 to 2019, 250,115 deaths associated with HF and sepsis were recorded among older adults, the majority being reported in medical facilities. The overall AAMR escalated from 28.8 in 1999 to 33.7 in 2019. AAMRs were more pronounced in men (33.9) than in women (25.5). Non-Hispanic (NH) Black/African American individuals exhibited the highest AAMRs (42.4). At the same time, NH Asian/Pacific Islanders reported the lowest (18.9). AAMRs were higher in non-metropolitan areas (31.4) and the Southern region (31.1). State-level disparities revealed the highest AAMRs in Mississippi (45.4) and the lowest in Arizona (12.1).

Conclusion:

Mortality from HF and sepsis has increased over the last 20 years, with NH Black/African individuals demonstrating the greatest increases. Future studies should investigate the mechanisms underlying this increase, particularly focusing on the factors that drive disparities, to develop targeted interventions for vulnerable groups.

2025-08-01·International Journal of Surgery Case Reports

Angiosarcoma of liver: A case report of a 56-year old with a highly aggressive tumor

Article

作者: Khan, M Siddique ; Qureshi, Abdal ; Khan, Aimal ; Younas, Mahad ; Noor, Saba ; Gohar, Manal

INTRODUCTION AND IMPORTANCE:

Hepatic angiosarcoma is a rare and aggressive tumor of the vascular endothelial cells with a poor prognosis. Due to its nonspecific symptoms and rapid progression, early diagnosis poses a significant challenge. Histopathology and immunohistochemistry are essential for confirmation; however, treatment options remain limited.

CASE PRESENTATION:

A 56-year-old male presented to us with right upper quadrant pain, anemia, and mild ascites. Computed Tomography (CT) imaging revealed multiple vascular liver and spleen lesions, initially suspected as metastatic. Tumor markers and Fine Needle Aspiration Cytology (FNAC) of a thyroid nodule were performed which turned out to be inconclusive. Due to internal hemorrhage, an emergency left lateral segmentectomy was performed. Cluster of Differentiation 34 (CD34) and Erythroblast transformation specific regulated gene (ERG) histopathology confirmed hepatic angiosarcoma. The patient was stable postoperatively and referred for oncology care. However, the patient deteriorated soon after and died due to massive intra-abdominal hemorrhage before initiating chemotherapy.

CLINICAL DISCUSSION:

Hepatic angiosarcoma is often multifocal with rapid metastasis, making complete resection almost impossible. CT and Magnetic Resonance Imaging (MRI) aid in detection but histopathology with vascular markers CD34 and ERG are essential for definitive diagnosis. In light of lack of treatment options surgical resection offers the best survival for localized disease, while chemotherapy and Transarterial Chemoembolization (TACE) remain good palliative options. With a median survival of 6 months, the prognosis of this disease is highly dismal.

CONCLUSION:

Hepatic angiosarcoma is a highly fatal condition with limited treatment options. Histopathology is crucial for diagnosis, and surgery remains the best option for localized cases. Early recognition is key to improving outcomes.

2025-08-01·IJC Heart & Vasculature

Comparison of mortality trends in patients with rheumatic mitral valve disease and nonrheumatic mitral valve disease: A retrospective study in US from 1999 to 2020

Article

作者: Ricci, Fabrizio ; Ahmed, Sophia ; Nkomo, Vuyisile ; Alkhalil, Mohammad ; Akram, Umar ; Awad, Wael ; Ashraf, Hamza ; Khanji, Mohammed ; Ahmed, Raheel ; Ahmad, Shoaib ; Ahmed, Shahzaib ; Ahmad, Eeman ; Ullah, Irfan ; Chahal, Anwar A ; Bates, Matthew

BACKGROUND:

Mitral valve disease (MVD) can have both rheumatic and nonrheumatic etiologies. However, differences in mortality remain unknown.

METHODS:

We extracted age-adjusted mortality rates (AAMRs) per 100,000 persons from the CDC WONDER database and stratified them by sex, region, and race. Annual percent change (APC) and average annual percent change (AAPC) were calculated using Joinpoint regression. Pairwise comparison was used to identify significant differences for MVD mortality trends between rheumatic and nonrheumatic patients.

RESULTS:

From 1999 to 2020, a total of 72,085 deaths were recorded in patients with rheumatic MVD, while 132,300 occurred in those with nonrheumatic MVD. The AAMR for nonrheumatic patients was twice as high as that for rheumatic patients throughout the study period, and AAPC differed significantly between the groups (p < 0.05). Females with rheumatic MVD were observed to have a higher AAMR (1.1) than their male counterparts (0.8), but those with nonrheumatic MVD exhibited a similar AAMR for both females and males. Among rheumatic patients, NH (non-hispanic) Whites were reported to have the highest AAMR (1.0), followed by NH Black or African Americans (0.8), Hispanic or Latinos (0.7), and NH Asian or Pacific Islanders (0.7). Among nonrheumatic patients, NH Whites exhibited the highest AAMR (1.9), followed by NH Black or African Americans (1.4), NH Asian or Pacific Islanders (1.1), and Hispanic or Latinos (1.0). The AAMR in Rural areas was higher than that in Urban areas for patients with both rheumatic and nonrheumatic MVD.

CONCLUSION:

Comprehensive public health strategies are essential to improving survival outcomes.

项与 Khyber Teaching Hospital 相关的新闻（医药）

2025-01-02

·drugs

More Than Half of People With Rheumatoid Arthritis Have Anemia

THURSDAY, Jan. 2, 2025 -- Anemia is prevalent among patients with rheumatoid arthritis (RA), according to a study published online Oct. 26 in Cureus . Jamal Shah, M.B.B.S., from Khyber Teaching Hospital in Peshawar, Pakistan, and colleagues examined the prevalence of anemia among 330 patients with RA presenting at a tertiary care hospital in 2023. The researchers found that more than half of participants had anemia (54.55 percent). The mean hemoglobin level among these patients was 11.41 g/dL, and the red blood cell count averaged 4.26 million/µL. The Disease Activity Score was higher in patients with anemia (mean of 5.23 versus 4.98 in those without anemia). Most people with anemia had elevated C-reactive protein levels (83.33 percent; mean C-reactive protein, 28.79 mg/L) and an elevated erythrocyte sedimentation rate (88.89 percent; mean erythrocyte sedimentation rate, 45.17 mm/hour). There were significant associations observed between anemia and longer disease duration, higher RA severity, and increased inflammatory markers. "These findings underscore the critical importance of routine screening and management of anemia in RA patients, particularly those with severe or prolonged disease, as addressing anemia could enhance overall patient outcomes and quality of life," the authors write. "Future research should focus on elucidating the mechanisms linking RA and anemia, conducting longitudinal studies to better understand these associations over time, and evaluating the effectiveness of anemia treatments in improving patient health." Abstract/Full Text Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.

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