Objective To investigate the clin. efficacy of OXiris-endotoxin adsorption technol. in the treatment of patients with sepsis/septic shock. Methods Thirteen patients with sepsis/septic shock treated with OXiris-endotoxin adsorption technol. who were admitted to Hebei Yanda Hospital from August 2018 to Feb. 2019 were selected as the research objects. The hemodynamic changes, lactate levels, procalcitonin (PCT) levels, urine output and systemic infection-related organ failure assessment (SOFA) scores were compared before and after treatment. Results At 24, 48, and 72 h after treatment, the patients′ heart rate, respiratory rate, and norepinephrine (NE) dosage were significantly decreased compared with those before treatment, and the differences were statistically significant (P<0.05). At 72 h after treatment, the lactate and sofa scores of the patients were significantly decreased compared with those before treatment, and the urine volume was significantly increased compared with those before treatment, and the differences were statistically significant (P<0.05). Compared with before treatment, procalcitonin (PCT) at 24, 48, and 72 h after treatment was significantly decreased, and the differences were statistically significant (P<0.05). Conclusion OXiris-endotoxin adsorption can effectively improve hemodynamic indicators, reduce lactate levels and infection indicators, and improve organ function, which has a good application prospect in patients with sepsis/septic shock.