Post-operative complications cause suffering and death among patients who have undergone surgery, increase the length of hospital stay, and thus increase costs, moreover, they reduce the quality of life and life expectancy among patients who have left the hospital. The aim of this study was to explore the trend of hospital admission due to intraoperative and post-procedural complications and disorders of the musculoskeletal system in England and Wales during the past 21 years. A secular trends study was conducted using hospital admission data extracted from the Hospital Episode Statistics (HES) database in England and the Patient Episode Database for Wales (PEDW) for the period between Apr. 1999 and Apr. 2020. Hospital admissions were identified using the diagnostic code (M96). Between 1999 and 2020, a total of 95,783 hospital admission episodes were recorded in England and Wales. Hospital admission rates increased by 6.42-fold [from 3.36 (95% CI 3.20-3.52) in 1999 to 24.92 (95% CI 24.52-25.32) in 2020 per 100,000 persons, p < 0.001]. The most prevalent hospital admissions causes were fracture of bone following insertion of orthopaedic implant, joint prosthesis, or bone plate, pseudarthrosis after fusion or arthrodesis, postlaminectomy syndrome, not elsewhere classified, and other post-procedural musculoskeletal disorders which accounted for 64.3%, 13.8%, 12.3%, and 8.5%, resp. The age group 75 years and older accounted for 49.1% of the total number of hospital admissions. Females contributed to 62.2% of the total number of hospital admission. Female hospital admissions increased 7.63-fold [from 3.58 (95% CI 3.35-3.80) in 1999 to 30.85 (95% CI 30.23-31.48) in 2020 per 100,000 people]. The male hospital admission rate increased by 4.94 times [from 3.13 (95% CI 2.92-3.35) in 1999 to 18.62 (95% CI 18.13-19.11) in 2020 per 100,000 people]. Intraoperative and post-procedural complications and disorders of musculoskeletal system hospital admissions increased in the past 20 years in England and Wales. More efforts should be directed towards reducing the risk of developing intraoperative and post-procedural complications. Elderly patients and females should be given higher emphasis regarding their risk of developing intraoperative and post-procedural complications and disorders of the musculoskeletal system.