Objective: To establish a method for the determination of astragaloside IV in Yiqi Weixue capsules. Methods: HPLC-ELSD was adopted with Hypersil C18 column (4.6 mm × 250 mm, 5 μm). The mobile phase was acetonitrile-water (36:64), and the flow rate was 1.0 mL/min. The temperature of the evaporative was 80°C, and the gas flow rate was 3 L/min. Results: The astragaloside IV had a good linearity in the range of 0.52∼10.4 μg (r = 0.9996). The average recovery was 96.27% with RSD = 1.00% (n = 6). Conclusion: The method is simple and accurate. It can be used for the quality control of Yiqi Weixue capsules.