Delving into the Latest Updates on 中国科学院南海海洋研究所 with Synapse

概览

疾病领域	数量

神经系统疾病	2
肿瘤	2

排名前五的药物类型	数量

小分子化药	2

关联

2

项与中国科学院南海海洋研究所相关的药物

Terpestacin derivatives 13 (South China Sea Institute of Oceanology)

靶点-

作用机制-

在研机构

中国科学院大学 [+1]

原研机构

中国科学院南海海洋研究所

在研适应症

胶质母细胞瘤

非在研适应症-

最高研发阶段临床前

首次获批国家/地区-

首次获批日期-

Terpestacin derivatives 15 (South China Sea Institute of Oceanology)

靶点-

作用机制-

在研机构

中国科学院大学 [+1]

原研机构

中国科学院南海海洋研究所 [+1]

在研适应症

胶质母细胞瘤

非在研适应症-

最高研发阶段临床前

首次获批国家/地区-

首次获批日期-

100 项与中国科学院南海海洋研究所相关的临床结果

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0 项与中国科学院南海海洋研究所相关的专利（医药）

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2,805

项与中国科学院南海海洋研究所相关的文献（医药）

2025-08-01·Food Chemistry

Recent insights into functional, structural, and digestibility modifications of starch through complexation with polyphenols: A review

Review

作者: Kraithong, Supaluck ; Deng, Shanggui ; Sangsawad, Papungkorn ; Zou, Zimo ; Theppawong, Atiruj ; Liu, Yonghong ; Bunyameen, Nasuha ; Chen, Xiaoe ; Gao, Jingrong ; Gao, Yuanpei

Starch-polyphenol complexes, formed through hydrogen bonding and hydrophobic interactions, significantly alter starch's functional, structural, and digestive properties. These complexes enhance thermal stability, reduce starch digestibility, and slow glucose release, offering potential benefits for glycemic control and functional food development. Polyphenols, including phenolic acids, flavonoids, tannins, lignans, and stilbenes, form inclusion and non-inclusion complexes with amylose, potentially increasing resistant starch (RS) content and lowering the glycemic index of foods, which may benefit individuals with diabetes. However, the effectiveness of these complexes depends on factors such as polyphenol structure, starch type, and processing conditions. In some cases, processing may degrade polyphenols, potentially enhancing starch digestibility. Future research should focus on understanding the underlying mechanisms, validating health benefits through in vivo studies, and optimizing processing techniques for functional foods targeting glycemic control. This will maximize the potential of starch-polyphenol complexes in developing healthier, more sustainable food solutions.

2025-08-01·Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology

New insights into the cytotoxic mechanism of marine-fungus-derived citrinin in three-dimensional Hepa1-6 cell model

Article

作者: Meng, Qingyue ; Mok, Simon Wing-Fai ; Zhang, Xiaoyong ; Wu, Keyue ; Huang, Riming ; Nong, Xuhua ; Liu, Yonghong ; Chen, Xinye

Although recent studies have demonstrated that Marine-fungus-derived citrinin (MFDC) has a significant cytotoxic effect in traditional two-dimensional (2D) monolayer cell culture and animal models, its precise cytotoxic mechanism, particularly in a three-dimensional (3D) cell culture model remains unclear. In this study, a 3D Hepa1-6 cell model based on Matrigel was used to investigate the potential cytotoxic mechanism of MFDC (0-100 μg/mL). The results revealed that, after treatment of 60-100 μg/mL MFDC, the increases of reactive oxygen species (ROS), lactate dehydrogenase (LDH), aspartate aminotransferase (AST) and alanine aminotransferase (ALT) in 2D cell model were more significant than those in 3D cell model. In addition, the metabolomic results revealed that the significantly altered metabolic pathways were pyrimidine metabolism and vitamin B6 metabolism, which might be related to the interference of MFDC in the pyrimidine synthesis pathway, as well as the upregulation of pyridoxine 5'phosphate oxidase and pyridoxal kinase activities. This study was the first to compare the cytotoxicology of 2D and Matrigel-based 3D cell models after MFDC induction, and to detect differences in cell metabolites after MFDC induction in 3D cell models, providing a new scientific basis for the use of a 3D cell model and a novel research idea for the cellular damage caused by MFDC.

2025-07-01·Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology

The histological and molecular response of acute hypoxia and reoxygenation in rainbow trout and steelhead

Article

作者: Jia, Kun-Tong ; Zhao, Zhen ; Gao, Qin-Feng ; Dong, Shuang-Lin ; Dong, Yun-Wei ; Chen, Xiao-Qun ; Zhou, Yan-Gen ; Zhang, Yue-Huan ; Huang, Zhi-Tao ; Wang, Yu-Hang

Hypoxia is a critical environmental stressor affecting fish survival and physiological function. Landlocked rainbow trout (Oncorhynchus mykiss) and anadromous steelhead (Oncorhynchus mykiss), two ecotypes of the same species, exhibit distinct physiological adaptations to fluctuating oxygen levels. To investigate their responses to acute hypoxia in these fish, brain histology and transcriptome analyses were conducted before stress, after hypoxia (12 and 24 h), and after reoxygenation (24 h). The results showed that the number of vacuolated nerve cells in the brain increased with the duration of hypoxia and decreased after 24 h of reoxygenation in both fish. RNA-Seq analysis identified 8409 differentially expressed genes (3952 in rainbow trout and 4457 in steelhead), one hypoxia-related module (MEred), and two significantly expressed gene clusters (cluster 3 in rainbow trout and cluster 8 in steelhead) through differential expression analysis, weighted gene co-expression network analysis (WGCNA), and Mfuzz clustering. KEGG pathway enrichment analysis revealed that signal transduction, immune response, angiogenesis, and apoptosis were significantly influenced by hypoxia in both fish. Distinct hypoxic responses were observed: in rainbow trout, ferroptosis, necroptosis, phosphatidylinositol signaling, calcium, and apelin signaling pathways were enriched, whereas in steelhead, the enriched pathways included platelet activation, Rap1, PI3K-Akt, Hippo, relaxin, and oxytocin signaling. Steelhead display marginally greater hypoxia tolerance than rainbow trout, although the difference is minimal, likely owing to their classification as the same species. These findings provide insight into the physiological and molecular mechanisms underlying hypoxia and reoxygenation stress in salmonids, contributing to a broader understanding of oxygen homeostasis in fish.

100 项与中国科学院南海海洋研究所相关的药物交易

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100 项与中国科学院南海海洋研究所相关的转化医学

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管线布局中药物为当前组织机构及其子机构作为药物机构进行统计，早期临床1期并入临床1期，临床1/2期并入临床2期，临床2/3期并入临床3期

临床前

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当前项目

药物(靶点)	适应症	全球最高研发状态

Terpestacin derivatives 13 (South China Sea Institute of Oceanology)	胶质母细胞瘤更多	临床前
Terpestacin derivatives 15 (South China Sea Institute of Oceanology)	胶质母细胞瘤更多	临床前