The purpose of this study is to investigate the likelihood of post-dilation bleeding using mechanical or electrocautery dilation. We hypothesized that the risk of bleeding is lower in the mechanical group.

开始日期2024-10-01

申办/合作机构

National Taiwan University Hospital

[+9]

NCT06566235 / Active, not recruitingN/AIIT

Cultural Adaptation and Implementation of Dialectical Behavior Therapy Skills Training Group for Adolescents With Emotional Disorders: a Feasibility Study and a Randomized Controlled Trial

The goal of this study is to learn if Dialectical behavior therapy Skills
Training for Adolescents (DBT-A-ST) works on emotional disorders in adolescents. The main questions it aims to answer are:
Does DBT-A-ST produce faster improvements (i.e., steeper slopes), compared to ASG, on primary and secondary outcome measures during treatment and 3-month follow-up?
Does DBT-A-ST produce greater improvements, compared to ASG, on primary and secondary outcome measures?
Participants will:
Randomly assigned to (a) a culturally adapted DBT-A-ST or (b) activities-based support group (ASG).
Received five assessments before the start of the trial (T1), after 4, 8 sessions (T2, T3), at post-intervention (T4), and 3-month follow-up (T5).

开始日期2024-08-01

申办/合作机构

Mackay Memorial Hospital

NCT06495060 / RecruitingN/AIIT

The Correlation Between Psychological Capital, Intention to Leave, Work Job and Environment Satisfaction, and Political Skills Among Different Generations Nurses

Purpose
1. To understand the current status of demographic characteristics, inclination to resign, Psychological Capital, work environment and job satisfaction, and political skills among incumbent clinical nursing staff across different generations.
2. To understand the correlation and interaction between demographic characteristics, inclination to resign, Psychological Capital, work environment and job satisfaction, and political skills among incumbent clinical nursing staff across different generations.
Expected outcomes
1. This study will provide objective and empirical data on the psychological capital, turnover intention, work environment and satisfaction, and political skills of clinical nursing personnel from different generations. By examining demographic variables, further exploration of the correlations among different attributes such as units, age, and positions (e.g., clinical nurses, nursing supervisors, specialist nurses) can be conducted. Through the research findings, the current status and needs of clinical nursing can be understood.
2. The results of this study will enable clinical nursing units in the future to implement measures to improve the psychological capital and address turnover intentions of nursing personnel from different generations and positions. Based on this objective and concrete data, relevant courses or training programs can be developed to retain excellent clinical nursing personnel.

开始日期2024-07-10

申办/合作机构

Mackay Memorial Hospital

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项与 Mackay Memorial Hospital 相关的文献（医药）

2025-02-01·JOURNAL OF AFFECTIVE DISORDERS

An exploratory analysis on the association between suicidal ideation and the microbiome in patients with or without major depressive disorder

Article

作者: Wu, Shu-I ; Chen, Vincent Chin-Hung

BACKGROUND:

Scarce research has investigated associations between suicidal ideation and the gut microbiota. We aimed to explore variations in the gut microbiome associated with suicidal ideation and major depressive disorder (MDD).

METHOD:

A case-control study compared abundances of fecal microbiota and biomarkers of gut permeability among patients with MDD, with or without suicidal ideation, and healthy volunteers without depression. Information on demographic variables and assessments of suicidal ideation (Beck Suicidal Ideation Scale), depression (Hamilton Depression Scale, Patient Health Questionnaire, Hospital Anxiety and Depression Scale- Depression), as well as anxiety (Hospital Anxiety and Depression Scale- Anxiety), were obtained. Univariate and multivariate regression model was performed to explore the possible predictors of suicidal ideation.

RESULTS:

Among the 140 participants, significant differences in Beta diversity were found between MDD patients with (n = 43) or without suicidal ideation (n = 34), and healthy volunteers (n = 42) (all p < 0.001). The strain of g-Phascolarctobacterium was found to have significant positive associations with scores of BSSI and BSSI Part 1 (suicidal ideation), particularly in MDD patients with suicidal ideation, after controlling for demographic and mood covariates. Mediation analyses revealed that g-Phascolarctobacterium may be a partial mediator between depression and suicidal ideation; however, it is also possible that the association between g-Phascolarctobacterium and suicidal ideation was partially mediated by the level of depression.

CONCLUSION:

We found different compositions, diversities, and possible mediating of the gut microbiome associated with suicidal ideations. Potential mechanisms need further investigation to establish whether this reflects a biological process that might be the focus for intervention development.

SYNOPSIS:

Our objective was to investigate whether the diversities and abundances of the gut microbiome varied in people with or without suicidal ideation and with or without MDD after considering possible demographic and mood confounders.

2024-12-31·ANNALS OF MEDICINE

Use of corticosteroids in non-infectious uveitis – expert consensus in Taiwan

Review

作者: Chan, Wei-Chun ; Lin, Chun-Ju ; Hwang, Yih-Shiou ; Chen, Ching-Long ; Lin, Yu-Chih ; Hwang, De-Kuang ; Chen, San-Ni ; Sheu, Shwu-Jiuan ; Kao, Tzu-En ; Chang, Yo-Chen ; Lin, Chang-Ping

PURPOSE:

To offer consensus on the utilization of corticosteroids (CS) for treating non-infectious uveitis in the context of clinical practice in Taiwan. This entails examining the different administration methods, their advantages and disadvantages, and considering alternative treatments according to the prevailing evidence and health policies.

METHODS:

Ten ophthalmologists and one rheumatologist convened on December 11, 2022, to review and discuss literature on the topic. The databases explored were the Central Cochrane library, EMBASE, Medline, PUBMED, and Web of Science using relevant keywords. The search spanned from January 1996 to June 2023. After the initial results of the literature review were presented, open voting determined the final statements, with a statement being accepted if it secured more than 70% agreement. This consensus was then presented at significant meetings for further discussions before the final version was established.

RESULTS:

A flow chart and nine statements emerged from the deliberations. They address the importance of CS in uveitis management, guidelines for using topical CS, indications for both periocular or intravitreal and systemic therapies, and tapering and discontinuation methods for both topical and systemic CS.

CONCLUSION:

While CS are a cornerstone for non-infectious uveitis treatment, their administration requires careful consideration, depending on the clinical situation and the specific type of uveitis. The consensus generated from this article provides a guideline for practitioners in Taiwan, taking into account local health policies and the latest research on the subject. It emphasizes the significance of strategic tapering, the potential for alternative therapies, and the importance of patient-centric care.

2024-12-31·ANNALS OF MEDICINE

Role of calcification in J-CTO score: a viewpoint of intraplaque guidewire tracking techniques

Article

作者: Tsai, Chia-Ti ; Wang, Yi-Chih ; Lin, Chia-Pin ; Hwang, Juey-Jen ; Chang, Chi-Jen ; Liu, Shih-Chi ; Liou, Jun-Ting ; Chiang, Jiunn-Yang ; Cheng, Jen-Fang ; Huang, Chi-Hung ; Lee, Chien-Lin ; Tsai, Cheng-Ting

BACKGROUND:

As the burden and distribution of calcification within chronic total occlusion (CTO) lesions can be diverse, its effect on CTO recanalization using multiple devices and techniques is debatable. This study investigated the role of calcification in wiring-based intraplaque tracking techniques for CTO recanalization.

METHODS:

A modified J-CTO score without counting calcification was used to analyze the procedures of 458 consecutive patients who underwent CTO interventions. Failed guidewire crossing and intraplaque tracking were considered procedural failures. Recanalization time details were analyzed for successful procedures.

RESULTS:

In patients with calcified CTO, the rate of procedural success only significantly declined to be lower than that of noncalcified CTO when the modified J-CTO score was ≥3 (77% vs. 94%, p = 0.008). In 422 patients with successful procedures, the presence of calcification was irrelevant to guidewire crossing time, but was accompanied with longer time from guidewire cross to final angiogram when the modified J-CTO score was 1-2 (53 ± 35 vs. 35 ± 17 [noncalcified] min, p < 0.001). Multivariate analyses showed that calcification was independently associated with procedural failure (odds ratio [OR] = 5.1, 95% confidence interval [CI] = 1.4-18.3) in lesions with modified J-CTO ≥3, and prolonged angioplasty/stenting procedures >60 min (OR = 4.8, 95% CI = 2.2-10.2) in successfully recanalized lesions with modified J-CTO score 1-2.

CONCLUSIONS:

Using intraplaque guidewire tracking, calcification was unfavorable for very difficult CTO lesions, and caused prolongation of angioplasty time for lesions with moderate complexity. This suggested that the role of calcification in the J-CTO score could be altered when different recanalization techniques were applied for CTO interventions.

项与 Mackay Memorial Hospital 相关的新闻（医药）

2024-09-16

·PRNewswire

PhytoHealth Corporation announced a new clinical study results published at 2024 ESMO Congress: PG2 plus preoperative chemoradiotherapy improves survival in patients with locally advanced esophageal cancer

TAIPEI and BARCELONA, Spain, Sept. 16, 2024 /PRNewswire/ -- A groundbreaking study conducted by PhytoHealth Corporation, a leading provider of botanical medicine, has revealed that combining Astragalus Polysaccharides (PG2®Lyo. Injection) with standard concurrent chemoradiotherapy (CCRT) significantly improves survival rates for patients with advanced esophageal cancer. The study enrolled 38 patients with stage IIb to IIIb esophageal cancer. Participants were randomly assigned to receive either CCRT alone or CCRT combined with PG2, a proprietary extract of Astragalus membranaceus roots developed by PhytoHealth Corporation. Results showed that patients who received PG2 in addition to CCRT experienced significantly longer overall survival compared to those who received CCRT alone. Furthermore, the combination therapy resulted in a higher tumor objective response rate. The study also found that PG2 helped strengthen the immune system by modulating the tumor immune microenvironment (TIME) and enhancing the suppression of tumor growth. 'These findings offer a new hope for patients with esophageal cancer,'' said Dr. Wen-Chieh Huang, Chief of Division of Thoracic Surgery at Mackay Memorial Hospital, Taiwan and the Principal Investigator of the clinical trial for PG2, a drug for cancer-related fatigue (CRF) relief developed by PhytoHealth Corporation, Taiwan. "PG2 has the potential to become a valuable addition to the standard treatment regimen, and can achieve improved patient outcomes.'' The data will be presented as a poster at the prestigious 2024 ESMO Congress. [ESMO abstract link]. Dr. Huang noted that treatment options for esophageal cancer patients are relatively limited compared to those for other cancers. However, this study has shown that PG2 combination therapy can reduce inflammation markers in the blood, decrease the differentiation of macrophages towards the M2 type, and even help shrink tumors while improving survival rates. This represents a significant breakthrough in the treatment of esophageal cancer. Dr. Huang further added that esophageal cancer patients often face tremendous challenges during treatment, with many unable to complete their therapy. However, by incorporating CRF medication, most patients were able to regain their strength, complete the full courses of cancer treatment, and achieve the expected therapeutic effects. Esophageal cancer is a challenging disease with high recurrence rates and poor survival outcomes. PG2, previously established as a treatment for cancer-related fatigue (already approved by Taiwan Food and Drug Administration) has shown promise as a potential treatment enhancer. This latest discovery marks a significant advancement in the ongoing battle against this challenging cancer. About PhytoHealth Corporation PhytoHealth Corporation is a leader in the development and manufacturing of botanical medicine and natural health products based in Taiwan. With a focus on scientific research and innovation, PhytoHealth is committed to providing safe, effective, and high-quality products that support overall health and well-being. Contact: Alison [email protected] Logo - WANT YOUR COMPANY'S NEWS FEATURED ON PRNEWSWIRE.COM? 440k+ Newsrooms & Influencers 9k+ Digital Media Outlets 270k+ Journalists Opted In GET STARTED