Delving into the Latest Updates on University of Basilicata with Synapse

概览

疾病领域	数量

肿瘤	1

排名前五的药物类型	数量

小分子化药	1

排名前五的靶点	数量

HASPIN	1

关联

1

项与 University of Basilicata 相关的药物

LDN-1929660

靶点

HASPIN

作用机制

HASPIN抑制剂

在研机构

University of Basilicata

原研机构

University of Basilicata

在研适应症

肿瘤

非在研适应症-

最高研发阶段药物发现

首次获批国家/地区-

首次获批日期-

1

项与 University of Basilicata 相关的临床试验

NCT05939466

/ Completed临床4期IIT

Is Low Dosage of Medical Cannabis Effective for Treating Pain Related to Fibromyalgia?

The goal of this interventional study is to learn about the effect of Medicinal Cannabis (Bedrocan®) on Fibromyalgia patients with pain resistant to conventional therapy. The main question the trial aims to answer are:
Is Bedrocan® effective for treating fibromyalgia-related pain in patients resistant to conventional therapy?
Can a low dosage of medical cannabis taken as a decoction reduce fibromyalgic pain?
All patients were trained on how to make the decoction: therapy was started with 100 mg/day (1 folder) and increased to 200 mg/day (2 folders) in non-responders.

开始日期2021-03-01

申办/合作机构

University of Basilicata

100 项与 University of Basilicata 相关的临床结果

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0 项与 University of Basilicata 相关的专利（医药）

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7,184

项与 University of Basilicata 相关的文献（医药）

2025-12-31·Journal of Maps

Habitat types of ‘Abruzzo, Lazio and Molise National Park’ and adjoining Natura 2000 areas (Italy)

作者: Filibeck, Goffredo ; Sammarone, Luciano ; Cancellieri, Laura ; Rosati, Leonardo ; Gentile, Carmelo ; Sulli, Cinzia

2025-07-01·Geological Society, London, Special Publications

The Modern and Ancient Central-Mediterranean Gateways

作者: Longhitano, Sergio G. ; Chiarella, Domenico ; Slootman, Arnoud

Gateways, seaways, and straits are physical elements of sedimentary basins that are hierarchically distinguished based on their dimensions and temporal persistence. The term ‘gateway’ applies to any oceanographic or marine connection, regardless of its size (width and length), duration, and depth (shallow vs. deep water). Seaways are broad marine passages, spanning from 100s to 1000s of kilometres in width, and active in the range from 100s of years to 10s of kyr in geological time. Straits are narrower passageways, connecting sub-basins within larger marine areas, persisting for no longer than 10 kyr and producing a distinct sedimentary record as individual depositional systems.In this paper, we focus on the Modern Central-Mediterranean Gateway (MCMG), nowadays represented by the coalescent Strait of Sicily, Egadi Islands and the Messina Strait. These connections, linking the western with the eastern Mediterranean sub-basins, drive continuous tidally-modulated water exchange and sediment transport, representing an example of a modern gateway. Then, we provide field-based examples of the sedimentary record of the former gateway, referred to as the Ancient Central-Mediterranean Gateway (ACMG), here represented by four major straits that developed during the Pliocene-Quaternary along localized grabens dissecting the southernmost edge of the Italian peninsula. We discuss the geological features of each of these straits, along with their depositional architectures and facies. These elements record the initiation of specific depositional processes, possibly enhanced by a stronger penetration of the Atlantic Water Inflow from the Gibraltar Strait, reinforced by the onset of the northern hemisphere glaciation.

2025-03-01·Food Chemistry

Aglianico grape pomace as a source of antioxidant and anti-proliferative biomolecules: Eco-friendly extraction and HRMS/MS-based molecular networking

Article

作者: Milella, Luigi ; Ponticelli, Maria ; Costantino, Valeria ; Faraone, Immacolata ; Labanca, Fabiana ; Sinisgalli, Chiara ; Esposito, Germana ; Scognamiglio, Paolo

Grape pomace (GP), a by-product of the wine supply chain process, contains bioactive molecules with known healthy properties. This study examines the impact of different extraction techniques on three GPs of Aglianico cultivar [Cantine del Notaio, Barile, and Torrecuso]. Five eco-friendly extractive techniques [maceration (MAC), digestion (DIG), accelerated solvent extraction (ASE), microwaves (MW), and ultrasound (US)] were used with 50 % ethanol/water as solvent. Spectrophotometric assays showed that DIG and ASE extracts had the highest antioxidant activity and specialized metabolite content. Using the HRMS/MS-based molecular networking, DIG and ASE extract metabolome profiles were analyzed, identifying unknown compounds and known ones with validated antioxidant and chemopreventive effects. In vitro cell-based assay on HepG2 cells demonstrated that Barile GP DIG extract has the highest anti-proliferative activity. Hence, this work provides insight into the potential application of Barile GP DIG extract as a rich source of specialized metabolites with antioxidant and anti-proliferative activity.

100 项与 University of Basilicata 相关的药物交易

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100 项与 University of Basilicata 相关的转化医学

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