Sriram Chandra Bhanja Medical College Hospital

更新于：2025-01-23

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项与 Sriram Chandra Bhanja Medical College Hospital 相关的临床试验

NCT03236740

/ Completed临床4期IIT

Doppler Analysis of Ovarian Stromal Blood Flow Changes After Treatment With Metformin Versus Ethinylestradiol-cyproterone Acetate in Women With Polycystic Ovarian Syndrome

This study is undertaken to compare the effects of treatment with commonly used OCP containing ethinylestradiol-cyproterone acetate and metformin in women with PCOS. Special attention will be paid to changes in ovarian stromal blood flow by using Color Doppler and they will be correlated with changes in hormonal parameters post-treatment.

开始日期2017-08-01

申办/合作机构

Sriram Chandra Bhanja Medical College Hospital

NCT02866786

/ Completed临床4期IIT

The Effects of Treatment With Oral Contraceptive Pill Containing Ethinyl Estradiol-Cyproterone Acetate and Metformin on Clinical, Hormonal, Metabolic and Ultrasonographic Characteristics in Polycystic Ovarian Syndrome

Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorder in women of reproductive age and is a leading cause of infertility due to anovulation. Oral contraceptive pills (OCPs) are considered as first line medical therapy to regularize menses in woman with PCOS. However they may worsen the metabolic profile of patients by elevating insulin resistance which is already deranged in PCOS. As there is higher prevalence of insulin resistance in Indian women with PCOS, insulin sensitisers like metformin may be more beneficial. Hence this study is undertaken to compare the combined effect of metformin and OCPs on the clinical, hormonal, metabolic and ovarian ultrasonographic characteristics in patients with PCOS and to evaluate whether this combination of drugs is more advantageous than OCPs or metformin alone in improving the clinical and metabolic profile.

开始日期2016-08-15

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Sriram Chandra Bhanja Medical College Hospital

100 项与 Sriram Chandra Bhanja Medical College Hospital 相关的临床结果

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项与 Sriram Chandra Bhanja Medical College Hospital 相关的文献（医药）

2025-01-02·Cureus

Psychosocial and Economic Burden on Families of Children With Cerebral Palsy: A Correlation With Locomotor Severity

Article

作者: Nayak, Bibhu Prasad ; Naaz, Falak ; Panigrahi, Sumanta ; Mohakud, Nirmal Kumar

BACKGROUNDCerebral palsy (CP) is a condition that often has significant psychosocial and economic impacts on the caregivers of affected children.OBJECTIVEThis study aimed to assess the association between the Gross Motor Function Classification System (GMFCS) level and the psychosocial and economic impact on caregivers of children with CP.METHODOLOGYA hospital-based cross-sectional observational study was conducted on children with CP aged 2-14 years, admitted to the Inpatient Department (IPD) or attending the District Early Intervention Center (DEIC) for physiotherapy at a teaching hospital in Odisha, from December 2020 to November 2022. In DEIC, appropriate screening and therapy as per requirement is given to the high-risk infants. Early detection of CP is done. Children with CP come here with their parents for physiotherapy, occupational therapy, hearing, vision, and development assessment. Tools used included the GMFCS - Expanded and Revised (GMFCS-ER), a five-level classification system, the Modified Updated Kuppuswamy Socioeconomic Scale (2021) for socioeconomic status (SES), and the Pai and Kapur Family Burden Interview Scale.RESULTSA total of 160 children with CP were included in the study, with 98 males and 62 females, resulting in a male-to-female ratio of 1.58:1. Out of 160 children with CP, the socioeconomic distribution showed that 73 (45.6%) belonged to the upper-lower class, 68 (42.5%) to the lower-middle class, 9 (5.6%) to the lower class, and 10 (6.3%) to the upper-middle class. Regarding functional levels of 160 children with CP, 22 (13.8%) of children were in GMFCS class I, 30 (18.8%) in class II, 16 (10%) in class III, 17 (10.6%) in class IV, and 75 (46.7%) in class V. Financially, out of 160 families of children with CP, 75 (46.9%) families were moderately burdened, 84 (52.5%) were severely burdened, and only 1 (0.6%) reported no financial burden. Regarding psychosocial impact, 94 (58.8%) families experienced moderate disruption of family leisure, while 44 (27.5%) experienced severe disruption. Physical health was moderately affected in 73 (45.6%) families, and 14 (8.8%) reported a severe impact. Mental health was moderately affected in 88 (55%)of families, while 33 (20.6%) experienced severe mental health issues. There was a statistically significant association between the GMFCS level of the child and the psychosocial and economic burden on families.CONCLUSIONSThe study concludes that higher GMFCS levels in children with CP are associated with a greater psychosocial and economic burden on their families.

2024-12-01·BMJ Case Reports

Spontaneous transvaginal evisceration of small intestine in a case of long-standing uterine and rectal prolapse

Article

作者: Pattanaik, Prasoon ; Pattanaik, Sushila Kumar

Spontaneous transvaginal small bowel evisceration, without recent trauma or surgery, is extremely rare. Complications include bowel obstruction, perforation, gangrene, septicaemia and death, requiring urgent surgical intervention. We report a case of a woman in her late 60s, who presented with 70–75 cm of small intestine eviscerated through the vagina, alongside a long history of uterine and rectal prolapse. Due to oedema in the intestine and mesentery, a vaginal reduction attempt failed. An emergency lower midline laparotomy was performed with a gynaecologist present. The eviscerated ileum was reduced, viability confirmed and repairs were made to the posterior vaginal vault defect and the peritoneal rent in the Douglas pouch. A Thiersch procedure was performed for the prolapsed rectum. Definitive surgery for the prolapsed uterus and rectum was deferred due to low condition. She recovered and was discharged on the 10th postoperative day but died from a myocardial infarction 3 months later.

2022-01-01·Gene3区 · 生物学

Association and functional significance of genetic variants present in regulatory elements of SERPINB5 gene in gallbladder cancer

3区 · 生物学

Article

作者: Suryakant Parida ; Manjusha Dixit ; Kirti Kumari Sinha ; J. Vinay ; Shivaram Prasad Singh

SERPINB5 is a mammary serine protease inhibitor, which is involved in various cellular functions. The aberrant expression of SERPINB5 is reported in many cancers along with GBC but limited information is available about its role in genetic predisposition for GBC. We carried out case-control study in 206 cases and 219 controls. Promoter SNPs were genotyped by Sanger's sequencing. In-silico promoter analysis and luciferase reporter assay were done to elucidate the role of promoter variants in regulation of SERPINB5 expression. Out of four SNPs, three SERPINB5 promoter variants showed association with GBC in different models. The 'C' allele of variant rs17071138 was found to be significantly associated with GBC (p = 0.017). The 'T' allele of rs3744940 significantly increased the risk for GBC in dominant (p = 0.035) and additive models (p = 0.005). Also, rs3744941 'T' allele increased the risk for GBC by dominant (p = 0.042) as well as additive models (p = 0.016). In-silico promoter analysis and luciferase reporter assay revealed the probable regulatory role of the SERPINB5 promoter variant rs17071138 on the expression. Overall, our study reveals the genetic association of SERPINB5 promoter variants with GBC and possible role of rs17071138 in the regulation of expression.

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