Delving into the Latest Updates on 北京大学口腔医学院 with Synapse

概览

疾病领域	数量

免疫系统疾病	1

排名前五的药物类型	数量

外泌体药物	1
单克隆抗体	1

排名前五的靶点	数量

TRPV4(瞬时受体电位离子通道V成员4)	1
MIF(巨噬细胞移动抑制因子)	1

关联

2

项与北京大学口腔医学院相关的药物

Dental Pulp Stem Cell-Derived Exosomes (Peking University School and Hospital of Stomatology)

靶点

TRPV4

作用机制

TRPV4拮抗剂

在研机构

北京大学口腔医学院

原研机构

北京大学口腔医学院

在研适应症

骨关节炎

非在研适应症-

最高研发阶段临床前

首次获批国家/地区-

首次获批日期-

CN117138037

专利挖掘

靶点

MIF

作用机制-

在研机构

北京大学口腔医学院

原研机构

北京大学口腔医学院

在研适应症

皮肤和肌肉骨骼疾病

非在研适应症-

最高研发阶段药物发现

首次获批国家/地区-

首次获批日期-

125

项与北京大学口腔医学院相关的临床试验

ChiCTR2500101170

/ Suspended早期临床1期IIT

Study on the characteristics and regulation mechanism of oral microecology and immune microenvironment in periodontitis-diabetes comorbidity

开始日期2025-05-01

申办/合作机构

北京大学口腔医学院

ChiCTR2500101543

/ SuspendedN/AIIT

Long-lasting Toothache Relief Technology Research and Clinical Translation

开始日期2025-05-01

申办/合作机构

北京大学口腔医学院

ChiCTR2500099330

/ SuspendedN/AIIT

An applied study of internet-based cognitive behavioral therapy for improving the psychological state and quality of life of orthognathic surgery patients

开始日期2025-05-01

申办/合作机构

北京大学口腔医学院

100 项与北京大学口腔医学院相关的临床结果

登录后查看更多信息

0 项与北京大学口腔医学院相关的专利（医药）

登录后查看更多信息

242

项与北京大学口腔医学院相关的文献（医药）

2025-12-31·Emerging Microbes & Infections

Chronic cutaneous and mucosal mucormycosis: Rhizopus arrhizus as a major pathogenic fungus

Article

作者: Yu, Jinlei ; Fu, Meng ; Li, Xingyu ; Hai, Luming ; Liu, Fang ; Wang, Gang ; Miao, Chang ; Yan, Dong ; Zhu, Zhenlai ; Ma, Yubo ; Gao, Jixin ; Guo, Yanyang

Chronic cutaneous mucormycosis is a rare condition distinct from the acute form, characterized by a prolonged, indolent course and varied clinical presentations. This study presents a 5-year experience from a tertiary dermato-mycology clinic, identifying six cases, the majority of whom were immunocompetent, with trauma history reported in four patients. The median duration from symptom onset to diagnosis was 60 months. The primary pathogens identified were Rhizopus arrhizus, Mucor variabilis, and Lichtheimia ramosa. Histopathological analysis demonstrated the absence of fungal angioinvasion, a hallmark of acute mucormycosis, which likely accounts for the slower progression observed in chronic cases. Systemic Amphotericin B treatment achieved favourable outcomes in most patients though significant morbidity persisted in some cases. This case series underscores the clinical and pathological distinctions of chronic cutaneous mucormycosis, highlighting the potential influence of host factors and environmental conditions on chronicity. The predominance of Rhizopus arrhizus suggests that chronicity is driven more by hostpathogen interactions than fungal species-specific factors. Increased recognition of the atypical clinical features, such as diverse cutaneous manifestation and slower progression course, as well as the utilization of diagnostic tools including histopathology, fungal culture, and advanced molecular techniques, is essential for the timely diagnosis of this rare presentation.

2025-12-31·Journal of Oral Microbiology

Preliminary analysis of salivary microbiota in catathrenia (nocturnal groaning) using machine learning algorithms

Article

作者: Han, Fang ; Yu, Min ; Hao, Zeliang ; Wen, Yongfei ; Lu, Yujia ; Xu, Liyue ; Dong, Xiaosong ; Gao, Xuemei ; Zhang, Wanxin ; Gong, Xu

ObjectivesThe present study aimed to characterize the salivary microbiota in patients with catathrenia and to longitudinally validate potential biomarkers after treatment with mandibular advancement devices (MAD).Materials and methodsTwenty-two patients with catathrenia (12 M/10 F, median age 28 y) and 22 age-matched control volunteers (8 M/14 F, median age 30 y) were included in the cross-sectional study. Video/audio polysomnography was conducted for diagnosis. All patients received treatment with custom-fit MAD and were followed for one month. Ten patients (6 M/4 F) underwent post-treatment PSG. Salivary samples were collected, and microbial characteristics were analyzed using 16S rRNA gene sequencing. The 10-fold cross-validated XGBoost and nested Random Forest Classifier machine learning algorithms were utilized to identify potential biomarkers.ResultsIn the cross-sectional study, patients with catathrenia had lower α-diversity represented by Chao 1, Faith's phylogenetic diversity (pd), and observed species. Beta-diversity based on the Bray-Curtis dissimilarities revealed a significant inter-group separation (p = 0.001). The inter-group microbiota distribution was significantly different on the phylum and family levels. The treatment of MAD did not alter salivary microbiota distribution significantly. Among the most important genera in catathrenia and control classification identified by machine learning algorithms, four genera, Alloprevotella, Peptostreptococcaceae_XI_G1, Actinomyces and Rothia, changed significantly with MAD treatment. Correlation analysis revealed that Alloprevotella was negatively related to the severity of catathrenia (r²= -0.63, p < 0.001).ConclusionsHigh-throughput sequencing revealed that the salivary microbiota composition was significantly altered in patients with catathrenia. Some characteristic genera (Alloprevotella, Peptostreptococcaceae_XI_G1, Actinomyces, and Rothia) could be potential biomarkers sensitive to treatment. Future studies are needed to confirm and determine the mechanisms underlying these findings.

2025-12-01·Molecular Biology Reports

From heterogeneity to prognosis: understanding the complexity of tertiary lymphoid structures in tumors

Review

作者: Huang, Xueping ; Wang, Song ; Li, Jun ; Wang, Chuanbao ; Li, Keyi ; Zhang, Dongyan ; Xian, Xinmiao ; Wang, Yingying ; Fu, Bo ; Wu, Guohao

Tertiary lymphoid structures (TLSs) are aberrant lymphoid tissues found in persistent inflammatory settings, including malignancies, autoimmune disorders, and transplanted organs. The organization and architecture of TLS closely resemble that of secondary lymphoid organs (SLOs). The formation of TLS is an ongoing process, with varying structural features observed at different stages of maturation. The tumor microenvironment (TME) is a multifaceted milieu comprising cells, molecules, and extracellular matrix components in close proximity to the neoplasm. TLS within the TME have the capacity to actively elicit anti-tumor immune responses. TLSs exhibit tumor-specific and individual-specific characteristics, leading to varying immune responses towards tumor immunity based on their distinct cellular components, maturity levels, and spatial distribution. Cell interaction is the foundational elements of tumor immunity. Despite differences in the cellular composition of TLS, B cells and T cells are the main components of tumor-associated TLS。Recent research has highlighted the significance of diverse subtypes of B cells and T cells within TLSs in influencing the therapeutic outcomes and prognostic indicators of individual tumors. This review elucidates the diversity of TLS in terms of cellular composition, developmental stage, anatomical location, and the influence of cytokines on their initiation and progression. Furthermore, the article examines the involvement of B and T cells within TLS and the significance of TLS in relation to tumor prognosis.

100 项与北京大学口腔医学院相关的药物交易

登录后查看更多信息

100 项与北京大学口腔医学院相关的转化医学

登录后查看更多信息

组织架构

使用我们的机构树数据加速您的研究。

登录

或

查看完整样例数据

管线布局

2025年05月13日管线快照

管线布局中药物为当前组织机构及其子机构作为药物机构进行统计，早期临床1期并入临床1期，临床1/2期并入临床2期，临床2/3期并入临床3期

药物发现

1

临床前

登录后查看更多信息

当前项目

药物(靶点)	适应症	全球最高研发状态

Dental Pulp Stem Cell-Derived Exosomes (Peking University School and Hospital of Stomatology) ( TRPV4 )	骨关节炎更多	临床前
CN117138037 ( MIF )	皮肤和肌肉骨骼疾病更多	药物发现