The goal of this 20-25-year observational study is to investigate the outcomes of bone regenerative surgery in peri-implantitis. Two different techniques will be compared: surgery with a bone substitute alone and surgery with a bone substitute combined with a membrane, to determine their effectiveness and assess whether one is more effective than the other. The intention of this observational study is to learn more about the long-term effects of bone regenerative surgery in patients with peri-implantitis.
Patients will be called in for a clinical and radiographic examination of the surgically treated implant(s). Probing pocket depths, presence of pus, bleeding around the implant (s) and a radiograph of the implant (s).
To be able to compare with the 1, 3, 5 and 10 year measurements.

开始日期2025-01-01

申办/合作机构

Kristianstad University

NCT06306092

/ RecruitingN/AIIT

Promoting Teenage Sleep - for Better Mental Health and School Performance

The overall aim of this project is to evaluate the effectiveness of two school-based programs that have the potential to promote adolescent sleep and prevent future depressive symptoms. The programs will be offered to students aged 13-19 at Swedish high schools and upper secondary schools at the classroom level. The students will be compared to teaching as usual (control group).

开始日期2024-08-17

申办/合作机构

Kristianstad University

[+2]

NCT06374407

/ Not yet recruitingN/AIIT

Exploring the Interplay Between Diet, Obesity, Mental Health, and the Gut Microbiome. The MIND-GUT Digital Pilot Intervention Study.

This 12-week pilot study aims to evaluate the feasibility and effectiveness of a dietary intervention targeting diet, obesity, mental health, and the gut microbiome in promoting weight loss and enhancing mental health among obese men and women aged 30-50. Participants, excluding those with specific medical conditions, will be randomly assigned to either an intervention or control group using a meal planning smartphone app. Clinical assessments will include anthropometry, mental health questionnaires, dietary recalls, and stool sample collections. The study's endpoints include program retention, adherence, changes in body weight, mental health, and gut microbiome diversity. Statistical analyses will evaluate intervention effects and the potential mediating roles of the gut microbiome. This pilot study has implications for health policies, public healthcare, digital health companies, and the biotech and pharmacology industries. Future plans involve a large-scale intervention study in multiple countries with ongoing collaborations.

开始日期2024-06-01

申办/合作机构

University of Skövde

[+6]

100 项与 Kristianstad University 相关的临床结果

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0 项与 Kristianstad University 相关的专利（医药）

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项与 Kristianstad University 相关的文献（医药）

2025-01-01·Journal of Neurology

Balance and gait disorders in de novo Parkinson’s disease: support for early rehabilitation

Article

作者: Hansson, Oskar ; Elmståhl, Sölve ; Hagell, Peter ; Siennicki-Lantz, Arkadiusz ; Lindholm, Beata ; Franzén, Erika ; Dahlin, Lars B ; Odin, Per

AbstractBackgroundPostural instability is considered a late complication of Parkinson’s disease (PD). However, growing evidence shows that balance and gait problems may occur early in the disease.ObjectiveTo describe balance, gait, and falls/near falls in persons with newly diagnosed, untreated PD (“de novo”), and to compare this with persons with mild-moderate PD (Later PD). In addition, we evaluated differences relative to PD subtypes in de novo PD.MethodsDe novo (n = 54) and Later (n = 58) PD were assessed regarding motor symptoms, balance, gait, and falls/near falls.ResultsAt least 25% of de novo PD had impaired reactive balance and/or comfortable gait speed ≤ 1.0 m/s. At least 50% had abnormal dynamic balance. A third reported balance problems during dual-tasking. Five persons (9%) reported falls/near falls. The median (q1–q3) motor symptom score was 21 (14–28) in de novo PD and 13.5 (9–20) in Later PD (p < 0.001). Later PD performed worse on more balance-demanding tests and a higher percentage of individuals reported falls/near falls (p ≤ 0.048). De novo PIGD PD (n = 10) exhibited worse motor symptoms, reactive and dynamic balance, gait speed, mobility, and freezing of gait as compared to the non-PIGD de novo PD (n = 37) (p ≤ 0.049).ConclusionBalance and gait were impaired in de novo PD and most pronounced in PIGD subtype. In addition, balance difficulties during dual-tasking and falls/near falls were evident during this early stage. The lower scores of motor symptoms in Later PD did not result in better mobility, balance, or less falls/near falls indicating that medications have less effect on these symptoms.

2025-01-01·Radiotherapy and Oncology

Patient reported fatigue after proton therapy for malignant brain tumours – Is there a relation between radiation dose and brain structures?

Article

作者: Fransson, Per ; Björk-Eriksson, Thomas ; Nordström, Fredrik ; Olsson-Nevo, Emma ; Kristensen, Ingrid ; Blomstrand, Malin ; Langegård, Ulrica ; Rosenschöld, Per Munck Af ; Ahlberg, Karin ; Brodin, Patrik ; Sjövall, Katarina

BACKGROUNDFatigue may significantly effect everyday- and working life for radiotherapy patients. Some studies indicate a correlation between radiation dose and irradiated volume of the brain and the presence of fatigue. Our hypothesis was that patient reported outcome measures (PROMs) can improve our understanding of the patients' symptoms following proton beam therapy (PBT) and optimize PBT for future patients.METHODSThis study included 167 adult patients (>18 years) who received PBT for malignant brain tumours. Data on dose metrics to intra-cranial structures was obtained from PBT treatment plans. To explore fatigue and health related quality of life (HRQoL); Multidimensional Fatigue Inventory (MFI-20) and EORTC QLQ-C30 was used at 6-, 12-, 24- and 36 months post PBT. The correlation between fatigue and dosimetry was explored using Spearman's signed rank test.RESULTSNo severe fatigue was recorded during the 36 months follow-up. Correlations between higher radiation dose and worsened fatigue scores were generally weak (rho < 0.3). At 12 months post PBT, higher mean dose to the brain, brainstem, hippocampi and pituitary was correlated to worsened MFI Physical Fatigue. Further, Reduced Motivation according to MFI was correlated to higher radiation dose to the brainstem and the pituitary gland. At 36 months follow-up post-PBT, both Reduced Activity and Reduced motivation according to MFI were correlated to higher radiation dose to the brain, brainstem and hippocampi.CONCLUSIONProton beam therapy are well tolerated, with similar degree of fatigue pre- and post PBT. Achieving further reduction in mean brain dose appears beneficial.

2025-01-01·Heliyon

Conceptual and empirical item hierarchies of person-centred outpatient care

Article

作者: Gasser, Fredrik ; Westergren, Albert ; Bala, Sidona-Valentina ; Ekstrand, Joakim ; Hagell, Peter

IntroductionThe Person-Centred Care instrument for outpatient care (PCCoc) is a 36-item patient-reported experience measure with 4 ordered response categories, that aims to capture the degree of perceived person-centred care (PCC) from a patient perspective among persons with long-term conditions. The PCCoc is based on a framework that conceptualises outpatient PCC from lower to higher levels of perceived PCC, from personalisation via shared decision-making to empowerment, where 35 of the PCCoc items are a part of the framework's hierarchy.AimTo investigate to what extent empirical item responses are consistent with the hierarchical PCCoc conceptual framework among persons with long-term conditions in outpatient care.MethodsPCCoc data (323 responses) from persons with long-term psychiatric, cardiological, rheumatological or neurological conditions were analysed. The Rasch measurement model (RMM) was used to evaluate model fit and the empirical item ordering. Correspondence between the empirical and conceptually expected item hierarchies was assessed graphically and using the polyserial correlation between RMM derived item locations and their a-priori expected rank order.ResultTwo items showed clear misfit to the RMM. The polyserial correlation between empirical item locations and the expected rank order using all 35 PCCoc items was 0.64; after removing the 2 misfitting items it was 0.71. In addition, subtests (i.e., testlets consisting of a combination of items belonging to the respective hierarchical domains) were created to account for any local dependency. Testlet locations on the hierarchical continuum indicated good correspondence between empirical data and the conceptual hierarchy when based on 35 as well as 33 items. Both testlet analyses had a polyserial correlation of 0.99 between testlet locations and the expected rank order.ConclusionThe observed correspondence between empirical data and the conceptual framework indicates that the PCCoc reflects the underlying framework, and therefore can be a valuable instrument to support targeted PCC-promoting interventions.

100 项与 Kristianstad University 相关的药物交易

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100 项与 Kristianstad University 相关的转化医学

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