OBJECTIVESThe PROMISE project (person-centered eHealth for treatment and rehabilitation of common mental disorders) applied a person-centered eHealth intervention as an add-on to usual care to improve the health of patients with common mental disorders (CMDs). This study aimed to evaluate the cost-utility of this intervention compared to usual care alone among patients with CMDs in Western Sweden.METHODSAn open randomized controlled trial was conducted from February 2018 to June 2020 with 100 study participants in the intervention group and 106 in the control group. In the intervention group, patients received person-centered eHealth services through telephone and a web-based digital platform, in addition to the usual care, while the control group received usual care alone. Data were collected using questionnaires, extracted from national and regional databases and registers, and translated to costs using national statistics. The incremental cost-effectiveness ratio (ICER) was determined using quality-adjusted life-years (QALYs) and costs from a societal perspective. The analysis followed the intention-to-treat principle over a one-year time horizon.RESULTSThe add-on person-centered eHealth intervention resulted in an average incremental cost per patient of SEK -20,296 and an average incremental gain in QALYs of 0.0054 compared to usual care. This resulted in an ICER value of -3,776,895, which, in sensitivity analyses, exhibited a 76.3% probability of being cost-effective.CONCLUSIONAdd-on person-centered eHealth interventions improves upon the usual care only for patients on sick leave for CMDs. This approach has proven to be cost-effective in managing CMDs and supporting better outcomes for patients on sick leave.