Anterior Cruciate Ligament (ACL) is a prevalent injury, particularly among young and physically active individuals. The efficacy of transcranial direct current stimulation (tDCS) and exercise-based rehabilitation on neuromuscular control in post-ACL reconstruction patients is evaluated, and these techniques are combined.

开始日期2025-05-22

申办/合作机构

Universidad Católica de Valencia San Vicente Mártir

NCT06932406

/ Not yet recruitingN/A

Orofacial Pain Self-management: Personality Moderation Effect - Randomized Clinical Trial

The objective of this clinical trial is to study the effect of self-management on pain perception in patients with chronic orofacial pain and temporomandibular disorders (TMD) comparing it with the conventional treatment proposed by the TMD clinical practice guidelines. It also evaluates its effect on function and various psychosocial variables.
As a secondary objective, this work proposes to study the variability between patients, in terms of personality factors, as moderators of the effect of treatment on pain perception. Including in the proposed statistical models certain covariates such as perception and/or coping with stress, anxiety and other psychosocial variables.
This is a randomized clinical trial with two intervention groups and three measurement times (T0; pre-intervention, T1; post-5 weeks and T2; post-6 months). The experimental group will be applied a protocol based on self-management, which includes: therapeutic education, cognitive-behavioral tools, therapeutic exercise of the temporomandibular region, mind-body strategies and modifications of aspects related to lifestyle. The control group will carry out an intervention program based on the Clinical Practice Guidelines for the Management of Temporomandibular Joint Disorders (Gopi et al., 2021). Therefore, using a set of tools based on therapeutic education, cognitive-behavioral tools for bruxism and other parafunctional habits, temporomandibular region exercises and manual therapy.

开始日期2025-05-01

申办/合作机构

Universidad Católica de Valencia San Vicente Mártir

NCT06783374

/ RecruitingN/A

Effect of a Peripheral and Central Neuromodulation Protocol Combined With the Application of Therapeutic Exercise in Patients Diagnosed With Urinary Incontinence. A Randomized Control Trial (RCT)

Urge urinary incontinence (UUI) is a component of the condition known as overactive bladder, a severe and debilitating chronic disorder affecting healthcare systems worldwide. The efficacy of therapeutic exercise and neuromodulation in the treatment of UUI is evaluated, and these techniques are combined.

开始日期2025-03-04

申办/合作机构

Universidad Católica de Valencia San Vicente Mártir

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2,083

项与 Universidad Católica de Valencia San Vicente Mártir 相关的文献（医药）

2025-09-01·Medicina de Familia. SEMERGEN

Estado de malnutrición como factor pronóstico de eventos cardiovasculares adversos mayores (MACE) en los pacientes con fibrilación auricular

Article

作者: García-Olcina, M ; Balado-Albiol, M T ; Moltó-Balado, P ; Clua-Espuny, J L ; Simeó-Monzó, A ; Serra-Garcia, A ; Canela-Royo, J ; Reverté-Villarroya, S

OBJECTIVETo examine nutritional status among patients with atrial fibrillation (AF) and its relationship with major adverse cardiovascular events (MACE), and to determine whether nutritional status is a risk factor for MACE in patients with AF.MATERIAL AND METHODSObservational, retrospective, community-based study (n=40,297) aged 65-95years in Terres de l'Ebre (Catalonia, Spain) between 2015 and 2021. A total of 2,574 patients with a diagnosis of AF were included. The CONUT scale was used to assess nutritional status and Cox regression analyses were performed.RESULTS67.91% of AF patients developed MACE. Malnutrition as assessed by the CONUT scale was significantly higher in AF patients who developed MACE (P<.001). Malnutrition doubled the risk of MACE and was identified as a prognostic factor (HR: 1.06; 95%CI: 1.04-1.08; P<.001).CONCLUSIONSMalnutrition is a prognostic factor for MACE in AF patients. Poorer nutritional status doubles the risk of MACE.

2025-05-01·Journal of Autism and Developmental Disorders

Sensory Profile-2 in Autism Spectrum Disorder: An Analysis within the International Classification of Functioning, Disability and Health Framework

Article

作者: Marcilla-Jorda, Marta ; Grande, Catarina ; Coelho, Vera ; Rubio-Belmonte, César ; Moro-Ipola, Micaela

AbstractAutism spectrum disorder (ASD) is characterized by impairments in many functional areas requiring long-term interventions to promote autonomy. This study aims to map The Sensory Profile™ 2 (SP-2), one of the most widely used assessment tools in children with ASD, with the International Classification of Functioning, Disability and Health for Children and Youth (ICF-CY), developed by the World Health Organization (WHO). This will allow the identification of the functional dimensions covered by this instrument and the comparison with the ICF shortlist proposed for autism (ICF Core Set [ICF-CS]). The deductive content analysis described in the ICF Linking Rules was followed, along with a systematized process including statistical and reasoning techniques that could contribute to the improvement of ICF linking studies (Cohen’s Kappa and percentage of agreement). 218 codes were identified, 71% of them were codes related to the body functions chapters, mainly linked to perceptual functions (b160), emotional functions (b152), and temperament and personality functions (b126). Concerning activities and participation chapters (29%) the most frequently used codes were: focusing attention (d160), carrying out daily routine (d230), and walking (d450). Even though the SP-2 items do not assess most of the functional features regarded as essential in the ASD ICF-CS, SP-2 encompasses a majority of problems concerning body functions. This instrument may be considered as part of a multidimensional assessment approach, to complement other sources that are more likely to assess activity and participation dimensions and guide a functional intervention.

2025-04-01·International Journal for Parasitology

Mortality associated with Angiostrongylus cantonensis in non-human primates in Europe

Article

作者: Ahuir-Baraja, Ana Elena ; Barbero-Moyano, Jesús ; Garijo-Toledo, Magdalena ; Viana, David ; Barragán, Agustín ; Sansano-Maestre, José ; Montero, Estefanía ; Ortega, Joaquín ; García-Bocanegra, Ignacio ; Carbonell-Montes, M Dolores ; Bravo-Barriga, Daniel ; Alarcón-Elbal, Pedro María ; Martínez, Remigio

Between December 2020 and March 2022, three cases of fatal meningoencephalitis were documented in two red-fronted brown lemurs (Eulemur rufus) and a ring-tailed lemur (Lemur catta) at the Bioparc in Valencia, eastern Spain. Post-mortem analyses revealed moderate congestion in the meninges of the brain in all cases. Multifocal areas of hemorrhage were observed in one lemur, primarily in the cerebellum and brainstem. Histopathological examination showed mainly acute hemorrhagic and necrotic changes, together with moderate eosinophilic and/or histiocytic meningoencephalitis, with perivascular cuffing, and gliosis. Numerous nematode larvae were found in the meninges, brain, and spinal cord, with or without associated inflammation, hemorrhage, and necrosis. Considering the affected host species, nematode morphology, and its anatomical localization, Angiostrongylus cantonensis (Nematoda: Metastrongylidae) was suspected as the causative agent. Phylogenetic studies based on the internal transcriber spacer 1/cytochrome c oxidase subunit I (ITS1/COI) genes confirmed the initial suspicion of this zoonotic parasite and its relationship to sequences from the Balearic and Canary Islands. This is the first known detection of A. cantonensis in non-human primates in Europe and it represents one of the few occurrences reported in the Palearctic region to date. Further research on this zoonotic parasite is crucial to understanding its spread in Spain, assessing public health risks, and developing effective control measures to mitigate outbreaks and protect human and animal health.

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