This study aims to evaluate and screen out the factors related to the improvement of eustachian tube function after adenoidectomy and/or tonsillectomy, so as to guide the treatment of children's eustachian tube function before and after operation, and provide the treatment direction and methods for diseases related to eustachian tube dysfunction for people with adenoid hypertrophy and/or tonsil hypertrophy complicated with ETD.

开始日期2022-10-18

申办/合作机构

中山大学孙逸仙纪念医院

[+2]

NCT02861482

/ CompletedN/AIIT

Early Usage of Bakri Postpartum Ballon is More Effective for the Management of Postpartum Hemorrhage

Postpartum hemorrhage (PPH) is the top reason for maternal deaths in China. The four major causes of PPH include uterine atony, genital tract laceration, placenta factors and systemic medical disorders (including inherited and acquired coagulopathy). Management of PPH contains the application of uterotonic agents, using hemostasis agents, transfusion of blood component products, conservative procedures (intrauterine packing or balloon tamponade, compression sutures, vascular ligation and uterine artery embolization using sponges), and even hysterectomy.
The Bakri Balloon has attained its efficacy and popularity ever since it was invented by Doctor YN. Bakri. Although it is recommended by many countries as a routine procedure for PPH management, the Bakri Balloon is not yet a first choice in China due to lack in clinical data of preventive usage.
The aim of this study is to prove the efficacy and safety of the Bakri Balloon in early management of PPH.

开始日期2015-01-01

申办/合作机构

中山大学附属第一医院

[+10]

100 项与中山市小榄人民医院相关的临床结果

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0 项与中山市小榄人民医院相关的专利（医药）

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项与中山市小榄人民医院相关的文献（医药）

2025-01-09·Endocrine, Metabolic & Immune Disorders - Drug Targets

Network Pharmacology Unveils Multi-Systemic Intervention of Panax notoginseng in Osteoporosis via Key Genes and Signaling Pathways

Article

作者: Feng, Weili ; Wu, Weiwei ; Wei, Zhantu ; Wang, Xiaoping ; Wang, Qiyue ; Wu, Kezhou

Background:Panax notoginseng (Burk.) F. H. Chen (PN) is a traditional Chinese medicine that has been applied to prevent and treat osteoporosis. The mechanism of PN for osteoporosis remained a mystery.Objective:The objective was to reveal the therapeutic effect and illuminate the possible mechanism of PN for osteoporosis.Methods:The Traditional Chinese Medicine Database and Analysis Platform was searched to screen the potent ingredients of the PN and to analyze the potential therapeutic targets for osteoporosis. We excavated four disease databases to collect osteoporosis-related genes. After integrating the gene expression profile of osteoporosis and the chemical-protein data of PN, a protein-protein interaction network was constructed to demonstrate the interactions among the gene products. GO function, KEGG pathway, and docking analyses were executed.Results:Network pharmacology obtained 31 active ingredients and 134 targets for the treatment of osteoporosis. The key components were beta-elemene, quercetin, methyl palmitate, oleic acid, and hexanal. The results of GO and KEGG analyses showed that Panax notoginseng was beneficial for osteoporosis by influencing the main pathways including AGE-RAGE signaling pathway in diabetic complications, TNF signaling pathway, IL-17 signaling pathway, p53 signaling pathway, NF-kappa B signaling pathway, PI3K-Akt signaling pathway, MAPK signaling pathway, FoxO signaling pathway, and Wnt signaling pathway, modulating inflammation, metabolism, cell proliferation, cell survival, growth and angiogenesis. Panax notoginseng intervened in osteoporosis through multi-components, multi-targets, and multi-pathways.Conclusion:This study illustrates the mechanism of Panax notoginseng for osteoporosis, providing broader insights for novel research and developments of the Panax species for osteoporosis.

2025-01-01·International Journal of Nursing Studies

Comment on 'Effectiveness of non-instrumental early mobilization to reduce the incidence of deep vein thrombosis in hospitalized patients'

Letter

作者: Zhang, Xuerong ; Wang, Xiaoping

2024-10-01·Heliyon

Mild encephalitis/encephalopathy with reversible splenial lesion (MERS) associated with respiratory syncytial virus and Pseudomonas putida infection: A case report

Article

作者: Wang, Hui ; Jiang, Ying ; Ruan, Bofu ; Dai, Kai ; Zhou, Guonan ; Chen, Yanxiang

BackgroundClinically mild encephalitis/encephalopathy with a reversible splenial lesion (MERS) is a mild encephalopathy, which may be associated with various pathogens, including virus and bacteria. However, there have been no reports on MERS associated with co-infection by respiratory syncytial virus (RSV) or Pseudomonas putida in adults.Case presentationWe reported a 29-year-old Chinese woman with MERS associated with RSV and Pseudomonas putida. This woman presented with fever, sore throat, cough, and altered mental states. The results of RSV-RNA in the specimens from throat and sputum culture of Pseudomonas putida were positive. The initial head CT scan on the day of admission revealed abnormal hypodense lesions in the suprasellar cistern (SCC). Subsequent brain magnetic resonance imaging (MRI) also demonstrated abnormal hypersignals in the same region. The patient's altered mental status improved on day after ceftriaxone and low-dose corticosteroid therapy. The SCC hypersignal on MRI completely resolved after three weeks, and no recurrence of symptoms occurred during the two-month follow-up period.ConclusionsIt is the first reported case of MERS associated with RSV and Pseudomonas putida in the adult, which broadens the spectrum of potential etiologies in MERS. When a patient with a respiratory tract infection presents with neurological symptoms, the possibility of MERS should be considered.

100 项与中山市小榄人民医院相关的药物交易

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100 项与中山市小榄人民医院相关的转化医学

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