Effects of Dexmedetomidine Versus Ketamine on Inflammatory Response and Hemodynamic in Patients With Intraabdominal Sepsis: A Randomized Controlled Study

Inflammatory response and hemodynamic response in patients with intraabdominal sepsis and Effects of Dexmedetomidine versus ketamine on it .

开始日期2024-12-01

申办/合作机构

New valley university

NCT06387667

/ Not yet recruitingN/AIIT

Unveiling the Fungal Frontier: Characterizing Diversity and Antifungal Resistance in Immunocompromised ICU Patients With Respiratory Tract Infections

Immunocompromised individuals face a heightened risk of life-threatening fungal infections, which arise from a multitude of environmental and commensal fungi. Surveillance data from ICUs worldwide identifies Candida spp. as the dominant foe, responsible for 80% of such infections, earning it the dubious distinction of being the third most prevalent pathogen. While C. albicans holds the dubious crown as the most common Candida offender, recent years have witnessed a concerning trend toward non-Albicans candida, raising concerns about potential antifungal resistance.

开始日期2024-12-01

申办/合作机构

New valley university

NCT06697106

/ RecruitingN/AIIT

Can COX-2 Inhibitor Decrease Stricture Recurrence After Direct Vision Internal Urethrotomy?

To evaluate the efficacy and safety of nonsteroidal anti-inflammatory drugs (NSAIDs) in preventing urethral stricture recurrence after direct visual internal urethrotomy.

开始日期2024-11-20

申办/合作机构

New valley university

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项与 New valley university 相关的文献（医药）

2025-02-01·Archives of Biochemistry and Biophysics

MXene-encapsulated ZIF-8@Liposomes for NIR-enhanced photothermal therapy in hepatocellular carcinoma treatment: In vitro, in vivo, and in silico study

Article

作者: Alharbi, Hanan M ; Madkhali, Nawal ; Eldin, Zienab E ; Elbeltagi, Shehab

Photothermal therapy (PTT) utilizes near-infrared (NIR) light to enhance localized, non-invasive cancer treatments and drug delivery systems (DDS). Combination chemotherapy with PTT (chemo-PTT) offers multiple therapeutic advantages, involving synergistic effects, reduced side effects, and decreased drug toxicity. In this study, 2D titanium carbide (Ti₃C₂T_x) MXene nanosheets were encapsulated in a zeolitic imidazolate framework-8 (ZIF-8) to form (MX-ZIF-8) nanoparticles (NPs) for PTT applications. Sorafenib (SB), an anticancer drug was loaded onto MX-ZIF-8 and further modified with a liposomes (LPs) lipid bilayer to create (SB-MX-ZIF-8@LPs) nanocomposites. TEM imaging revealed that SB-MX-ZIF-8@LPs had a lamellar structure and spherical shape, with an average diameter of 75.2 nm and a zeta potential (ZP) of -8.4 ± 4.5 mV. Additionally, the PT stability, drug encapsulation, and in-vitro release kinetics of SB-MX-ZIF-8@LPs were assessed. These nanocomposites exhibited an impressive PT conversion efficiency of 55 % at 50 μg/mL under NIR irradiation. The cumulative release of SB from SB-MX-ZIF-8@LPs reached 86.15 % at pH 7.4 and 89.3 % at pH 4.8 under NIR over a period of 72 h, with an encapsulation efficiency of 87.34 %. MTT assays revealed strong cytotoxicity against HepG2 cells, with SB-MX-ZIF-8@LPs showing an IC₅₀ value of 2.7 μg/mL and inducing approximately 96 % total apoptosis. The SB-MX-ZIF-8@lip nanocomposite demonstrated excellent biological stability in a serum environment, retaining over 98 % of sorafenib and maintaining consistent particle size (∼347 nm) over 30 days. An in vivo xenograft study in BALB/c mice further demonstrated the efficacy of SB-MX-ZIF-8@LPs, with this treatment group showing the smallest tumor volume compared to other groups and a significantly higher tumor volume reduction than SB alone. Molecular docking studies indicated that SB exhibited strong binding affinities particularly with ABL1 (-8.7 kcal/mol) and EGFR (-9.3 kcal/mol). Docking interactions between MXene and SB, conducted using the Hdock Server, resulted in a docking score of -10.53, with one bond forming at a distance of 4 Å. These findings were consistent with experimental results, highlighting the favorable interaction between MXene and SB. ADMET analysis confirmed that MX-ZIF-8@LPs possessed favorable drug carrier properties, including high intestinal absorption (96.6 %), and low toxicity supporting its potential as an effective DDS for cancer therapy.

2025-02-01·Poultry Science

Effect of dietary microalgae on growth performance and health in meat-type quails

Article

作者: Alhotan, Rashed A ; El-Mekkawy, Mohamed M ; Attia, Youssef A ; Mohamed, Samar M ; El-Kholy, Mohamed S ; Cerbo, Alessandro Di ; Lestingi, Antonia ; Alagawany, Mahmoud ; Salah, Ayman S

The purpose of this work was to ascertain the impact of dietary inclusion of Dunaliella salina (Ds) and Arthrospira platensis (Ap) mixture as growth promoters on growth performance, carcass traits, liver and renal function, lipid profile, immunology and economics in quail chicks. 240 Un -sexed seven-day quail chicks were separated into four treatment groups with six replicates of ten chicks per group. The treatment groups are: control: basal diet; DsAp0.5: basal diet + 0.25 g Ds+ 0.25 g Ap/kg diet; DsAp1: basal diet + 0.50 g Ds+ 0.50 g Ap/kg diet; and DsAp2: basal diet + 1.00 g Ds+ 1.00 g Ap/kg diet. The outcomes of dietary inclusion of Ds plus Ap revealed a significant difference in live body weight at 5 week and body weight gain from (1-5wk) (P=0.049) and the group DsAp1 recorded the best results (191.19g, 5.69g). The mixture of Ds plus Ap did not significantly (P>0.05) change the feed intake during the experiment. The DsAp0.5 group significantly (P=0.019) presented the best feed conversion ratio during (1-5 wk of age) compared to the control and other groups. The finding showed a non-significant difference in carcass traits (P>0.05). Liver and kidney function markers were affected by the supplements, and DsAp2 group recorded the highest levels of total protein and albumin. The DsAp1 group significantly (P=0.003) presented the lowest level of alanine aminotransferase (ALT) and the DsAp2 group significantly (P<0.001) presented the lowest levels of aspartate aminotransferase (AST) and urea. Dietary supplementation of Ds plus Ap affected the lipid profiles of the quail. Dietary supplementation of Ds plus Ap mixture reduced the concentration of total cholesterol (TC), low-density lipoprotein (LDL), triglyceride (TG) and high-density lipoprotein (HDL) when compared to control (P<0.001). Furthermore, the immune parameters, complement 3 (C3) and lysozyme showed a non-significant variation with Ds plus Ap supplementation. The net revenue and economic efficiency of treated quails was significantly increased during the experiment (1-5 wks of age); the best values were observed in DsAp0.5 group. In conclusion, the use of Ds plus Ap mixture as growth promoters in quail diets improves the growth performance, liver functions and lipid profile.

2025-02-01·Medicinal Chemistry Research

Review: Chemical and biological features of genus Paralemnalia soft corals

作者: Mahmoud, Basma Khalaf ; Kamel, Mohamed Salah ; Khedr, Amgad I. M. ; el-dien, Radwa Taher Mohie ; Fouad, Mostafa A.

Abstract: Marine soft corals are plentiful sources of a wide range of natural products.They include an extensive array of chem. scaffolds that could eventually be utilized to develop novel drugs for human diseases due to the extraordinary diversity and number of bioactive small mols. identified from these animals.Soft corals belonging to the Paralemnalia genus (order Alcyonacea) are widely distributed throughout the Red Sea, Indian Ocean, Southeast Asia, and the Pacific Ocean.Numerous chem. components have been isolated and identified, including mainly sesquiterpenes, diterpenes, steroids, and fatty acids.Some compounds have been shown to exhibit various biol. activities such as anti-inflammatory, cytotoxic, neuroprotective, antibacterial, and antiviral properties.However, no reviews have been published focusing on this genus until now.Here in this review, we attempt to delve into the reported metabolites from genus Paralemnalia according to the produced species, their chem. structures, and their biol. potential.

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