Effects of Dexmedetomidine Versus Ketamine on Inflammatory Response and Hemodynamic in Patients With Intraabdominal Sepsis: A Randomized Controlled Study

Inflammatory response and hemodynamic response in patients with intraabdominal sepsis and Effects of Dexmedetomidine versus ketamine on it .

开始日期2024-12-01

申办/合作机构

New valley university

NCT06387667

/ Not yet recruitingN/AIIT

Unveiling the Fungal Frontier: Characterizing Diversity and Antifungal Resistance in Immunocompromised ICU Patients With Respiratory Tract Infections

Immunocompromised individuals face a heightened risk of life-threatening fungal infections, which arise from a multitude of environmental and commensal fungi. Surveillance data from ICUs worldwide identifies Candida spp. as the dominant foe, responsible for 80% of such infections, earning it the dubious distinction of being the third most prevalent pathogen. While C. albicans holds the dubious crown as the most common Candida offender, recent years have witnessed a concerning trend toward non-Albicans candida, raising concerns about potential antifungal resistance.

开始日期2024-12-01

申办/合作机构

New valley university

NCT06697106

/ RecruitingN/AIIT

Can COX-2 Inhibitor Decrease Stricture Recurrence After Direct Vision Internal Urethrotomy?

To evaluate the efficacy and safety of nonsteroidal anti-inflammatory drugs (NSAIDs) in preventing urethral stricture recurrence after direct visual internal urethrotomy.

开始日期2024-11-20

申办/合作机构

New valley university

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项与 New valley university 相关的文献（医药）

2025-09-01·Journal of Photochemistry and Photobiology A: Chemistry

Synthesis of novel bioactive amides derived from carbazole moiety with deep-blue and single-component white photoluminescence

作者: Sayed, Mostafa ; Tsutsumi, Osamu ; Tolba, Mahmoud S. ; Ahmed, Mostafa ; Younis, Osama ; Al-Hossainy, A. F.

This work focuses on the chem. synthesis of three fluorescent bioactive amides tethered carbazole moiety by coupling 3-amino-9-ethylcarbazole with different aliphatic carboxylic acids including valeric, hexanoic, and heptanoic acids.NMR spectroscopy and HRMS were utilized to confirm the claimed structure of the target compounds indicating good agreement.The antimicrobial activity of fluorescent amides was assessed against different strains of gram neg. and gram-neg. bacterial as well as fungi demonstrating outstanding activity close or same as the control.Moreover, the mol. design, DFT calculations, and photoluminescence characteristics of these dyes have been investigated.The examined materials solutions emitted a deep-blue emission.Interestingly, with the powders, on the other hand, a single component emitted white light.The creation of aggregated mols. in the solid state improved the emission intensity at long visible wavelengths, resulting in a change in the emission color from the solution to the powder.The studied materials also emitted consistently at high temperaturesFurthermore, the odd-even effect both on the mol. packing and emission characteristics has been proven.As a result, the mols. under investigation provide a unique combination of benefits: a simple mol. structure, deep-blue emitters, white emission from a single material, and an odd-even effect.

2025-08-01·Journal of Molecular Structure

Synthesis, photoluminescence, antimicrobial evaluation, molecular docking, and pharmacokinetic prediction of new pyrimidoselenolo[2,3-d]pyrimidine derivatives

作者: Saddik, Abdelreheem Abdelfatah ; Hassan, Abdelfattah ; Tolba, Mahmoud S. ; Younis, Osama ; Ahmed, Mostafa ; El-Dean, Adel M. Kamal ; Mohammed, Ahmed A. K. ; Hassanien, Reda ; Sayed, Mostafa

Selenopyrimidine compounds, though less explored than their thieno[2,3-d]pyrimidine counterparts, exhibit significant potential as multifunctional agents.In this study, a series of novel pyrimidoselenolo[2,3-d]pyrimidine compounds was synthesized using a straightforward methodol.The structural characterization of the compounds was performed using elemental analyses, FT-IR, ¹H NMR, and ¹³C NMR spectroscopy.Their antimicrobial activities were evaluated using the agar well diffusion method against various fungal and bacterial strains, with min. inhibitory concentrations (MICs) compared to ciprofloxacin and ketoconazole as standardsCompounds with Ph substituents displayed superior antibacterial and antifungal activities, while amino carboxamide derivatives showed comparatively lower efficacy.Addnl., the luminescence of selected mols. was explored in DMSO solutions and the solid state.Compounds exhibited strong absorption up to 450 nm and concentration-dependent emission behavior, with a clear red shift in emission spectra owing to the mol. aggregation.DFT calculations revealed significant changes in the structure of the ground and excited states, providing insights into the observed luminescence behavior.Mol. docking studies revealed a high affinity of target compounds to topoisomerase II enzyme.All target compounds were predicted to have acceptable physicochem. and pharmacokinetic parameters.Our findings feature the dual potential of selenopyrimidine derivatives as effective antimicrobial agents and promising candidates for luminescent applications.Thanks to combining biocompatibility and emission properties to present these compounds as possible candidates for biol. applications such as bioimaging and bioprobes.

2025-07-01·European Journal of Medicinal Chemistry

Novel benzenesulfonamide derivatives linked to diaryl pyrazole tail as potential carbonic anhydrase II/VII inhibitors with anti-epileptic activity

Article

作者: Eldehna, Wagdy M ; Mohamed, Mamdouh F A ; Nocentini, Alessio ; Supuran, Claudiu T ; Hefina, Mohamed M ; Alkabbani, Mahmoud Abdelrahman ; Zidan, Taha H ; Nemr, Mohamed T M ; Fadaly, Wael A A ; Giovannuzzi, Simone ; Abd El-Hameed, Abeer M

Two new series of 1,2,3-triazole benzenesulfonamide derivatives 16a-f and imino-thiazolidinone benzenesulfonamide derivatives 19a-f with diaryl pyrazole tail were synthesized as carbonic anhydrase (CA) II, VII inhibitors and assessed for antiepileptic activity. All compounds were tested in vitro for their inhibition activity against the human (h) carbonic anhydrase I, II, and VII isoforms. Among these series, compounds 16b, 16d, 19b, and 19d exhibited exceptional inhibitory activity against hCA II, with K_i 10.9-47.1 nM, and hCA VII, with K_i 8.4-23.6 nM, while the two series did not show significant activity against hCA I. Furthermore, 16b, 16d, 19b, and 19d were tested against in vivo pilocarpine-induced seizure model, and they showed excellent neuroprotective activity; they delayed seizure onset, reduced seizure severity, and improved survival rates compared to the pilocarpine group, which highlighted their efficacy in regulating neuronal excitability through CA inhibition and chloride homeostasis. Also, hippocampal levels of KCC2 and mTOR were analyzed, as these markers are critical in regulating neuronal excitability and are closely linked to epilepsy. Noteworthy, Compounds 16d and 19b surpassed the standard anti-convulsant valproic acid in key parameters, underscoring their superior efficacy. In addition, they do not show any significant neurotoxic effects or alterations in liver and kidney function. Moreover, the results of in vitro cytotoxicity of compounds 16d and 19b against Vero cells indicate their safety at the doses given (IC₅₀ = 59.7, 71.9 μM respectively) compared to acetazolamide (IC₅₀ = 32.3 μM). Finally, molecular docking of sulfonamide derivatives with hCA II (PDB code: 2h4h) and hCA VII (PDB code: 3ml5) was performed.

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