A Cross-sectional Study Describing the Current Status of Diagnosis and Treatment of Uroepithelial Cancer in Hospitals of Different Grades in Henan Province

A cross-sectional study describing the current status of diagnosis and treatment of uroepithelial cancer in hospitals of different grades in Henan Province

开始日期2024-10-30

申办/合作机构

The First Affiliated Hospital of Xinxiang Medical College

NCT06641934

/ Not yet recruitingN/AIIT

Current Survey on Chemotherapy-Related Myelosuppression and Clinical Management in Chinese County-level Tumor Patients

开始日期2024-10-20

申办/合作机构

The First Affiliated Hospital of Xinxiang Medical College

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285

项与 The First Affiliated Hospital of Xinxiang Medical College 相关的文献（医药）

2025-05-01·Journal of Affective Disorders

Depressive symptoms changes in the new-onset stroke patients: A cross-lagged panel network analysis

Article

作者: Wang, Lianke ; Hu, Bo ; Zhang, Peijia ; Wang, Panpan ; Qin, Ying ; Yao, Zihui ; Wang, Yu ; Zhang, Qiang ; Sun, Changqing ; Zhu, Zhengqi ; Xue, Wei ; Sun, Dequan ; Wu, Tiantian ; Miao, Jixing

BACKGROUNDEach year, there are approximately 10.3 million new stroke cases worldwide, with 2 million occurring in China. Post-stroke depression (PSD) is a common complication that negatively affects rehabilitation outcomes and increases long-term mortality.OBJECTIVEThis study used network analysis to investigate the cross-sectional and longitudinal networks between depressive symptoms in new-onset stroke patients with PSD, aiming to identify the key symptoms and predictive relationships among distinct symptoms during the acute phase and 6 months after the stroke.METHODSThis longitudinal descriptive study collected data from October 2022 to December 2023, including eligible new-onset stroke patients. Depressive symptoms were assessed using the CES-D scale, and network analysis was used to analyze the interactions between symptoms.RESULTS613 participants completed the data collection. The study found that D3 (Felt sadness) emerged as the central depressive symptom at both baseline and follow-up (EI value = 1.215 and 1.168, respectively). In the longitudinal network analysis, D7 (Sleep quality) displayed the strongest out-Expected Influence (value = 1.728), while D4 (Everything was an effort) showed the strongest in-Expected Influence (value = 1.322).LIMITATIONSThe self-report measure is adopted for all depressive symptoms in the study, and there may be some deviation.CONCLUSIONThese symptom-level associations at cross-sectional and longitudinal networks extend our understanding of PSD symptoms in new-onset stroke patients by pointing to specific key depressive symptoms that may aggravate PSD. Recognizing these symptoms is imperative for the development of targeted interventions and treatments aimed at addressing PSD in new-onset stroke patients.

2025-04-01·Pharmacology Biochemistry and Behavior

Early-life stress of limited bedding/nesting material induced recognition memory loss and decreased hippocampal VGluT1 and nectin3 levels in aged male mice

Article

作者: Wang, Ting ; He, Ze-Cong ; Yu, Ya-Jie ; Liu, Xiao ; Yin, Hui-Rong ; Su, Yun-Ai ; Sun, Ya-Xin ; Li, Ji-Tao ; Xie, Xiao-Meng ; Wang, Hong-Li ; Si, Tian-Mei

Exposure to early-life stress has been found to lead to enduring psychiatric symptoms, including cognitive impairments that persist into adulthood and even old age. In this study, we investigated the behavioral effects and molecular changes of a well-established animal model of early-life stress, the limited bedding and nesting (LBN) model, in aged male mice. After 16 months, stressed mice showed a marked impairment in novel and spatial object recognition tasks, but not in temporal order memory or spatial working memory in the Y-maze spontaneous alternation task. These cognitive deficits were accompanied by a reduction in VGluT1 expression and a lower VGluT1/VGAT ratio in the CA1 region of the hippocampus, as well as reduced nectin3 expression in the mouse hippocampus. No significant molecular alterations were observed in the medial prefrontal cortex. These data support the notion that early-life stress leads to cognitive impairments in aged male mice, and these effects may be associated with a dysregulated excitatory/inhibitory balance and reduced nectin3 levels in the hippocampus.

2024-02-25·Zhen ci yan jiu = Acupuncture research

电针督脉对脊髓损伤大鼠脊髓组织线粒体融合及神经干细胞增殖分化的影响.

Article

作者: Su, Kai-Qi ; Gao, Jing ; Chang, Wen-Tao ; Feng, Xiao-Dong ; Duan, Zhao-Yuan ; Wu, Ming-Li

目的: 观察电针督脉对脊髓损伤（SCI）大鼠损伤区脊髓组织中线粒体融合及神经干细胞增殖分化的影响，探讨电针促进SCI神经修复的机制。方法: SD大鼠随机分为假手术组、模型组和电针组，每组各15只。采用精密打击器打击法构建胸10节段SCI模型。电针组大鼠予以电针“大椎”“脊中”，30 min/次，1次/d，共14 d。用Basso-Beattie-Bresnahan （BBB）运动功能评分法评估大鼠后肢的运动功能；HE染色法、尼氏染色法观察大鼠损伤区脊髓组织病理变化及神经元数量；免疫荧光染色法检测大鼠损伤区脊髓组织中神经干细胞增殖标记物巢蛋白（Nestin）、线粒体融合相关蛋白视神经萎缩蛋白1（OPA1）及神经干细胞转录因子性别决定区Y框蛋白2（SOX2）的阳性表达；实时荧光定量PCR法、Western blot法检测大鼠脊髓组织中Nestin mRNA及蛋白的表达。结果: 与同时点假手术组比较，模型组大鼠造模后BBB评分降低（P<0.001）；脊髓组织中神经元肿胀、破裂、坏死严重，尼氏小体溶解严重，神经元数量减少（P<0.001）；Nestin、OPA1、SOX2阳性表达及Nestin蛋白和mRNA相对表达量均升高（P<0.001，P<0.05，P<0.01）。与模型组比较，电针干预第7、14天时电针组大鼠BBB评分，Nestin、OPA1、SOX2阳性表达，以及Nestin蛋白和mRNA相对表达量均升高（P<0.05，P<0.01，P<0.001），脊髓神经元受损程度减轻，尼氏小体溶解程度减轻，神经元数量增加（P<0.05）。结论: 电针督脉可改善SCI大鼠运动功能，促进SCI区域神经元修复，其机制可能与电针督脉促进损伤区脊髓组织线粒体融合蛋白OPA1表达，增强神经干细胞增殖分化有关。.

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