作者: Ma, Yongjian ; Zhou, Yan ; Zhu, Huizi ; Zhao, Lian ; Sun, Jing ; Zhao, Bing ; Meng, Qian ; Wang, Rong ; Zhai, Chunjuan ; Liu, Yun ; Yang, Xiaowei ; Li, Weidan ; Lin, Jiangong

BackgroundReduced survival of red blood cells (RBCs) in patients with chronic kidney disease (CKD) is thought to contribute to renal anaemia. Although renal anaemia improved greatly because of the wide use of erythropoiesis-stimulating agents (ESAs) and the advancement of dialysis techniques, RBC longevity seems not to be obviously ameliorated.MethodsIn this single-centre, single-arm trial, patients who had been undergoing haemodialysis and ESA therapy with epoetin alfa for at least 12 weeks changed their anti-anaemia drugs from epoetin alfa to oral roxadustat three times per week for 24 weeks. The primary endpoint was the change in RBC lifespan from baseline at week 24. The change in the circulating percentage of eryptotic RBCs, RBC deformability and RBC oxygen transport ability were also assessed.ResultsA total of 27 patients were enrolled, with 26 completing the full course of intervention. At baseline, the average RBC lifespan was 60.1 days [standard deviation (SD) 14.4; n = 27]. At the end of the study period, 26 patients had an RBC lifespan measurement (83.9 days on average; SD 21.9). The RBC lifespan increased by 22.8 days on average [95% confidence interval (CI) 15.5-30.0, P < .001]. This equated to an average RBC lifespan increase of 39.2% (95% CI 27.8-50.6). The percentage of circulating eryptotic RBCs, erythrocyte filtration index and the pressure at which haemoglobin is 50% saturated decreased significantly from baseline to week 24 (1.39 ± 0.44% versus 0.89 ± 0.25%, P < .0001; 0.29 ± 0.12 versus 0.16 ± 0.08, P < .0001 and 32.54 ± 4.83 versus 28.40 ± 2.29, P < .001, respectively).ConclusionRoxadustat prolonged RBC lifespan in patients with long-term haemodialysis.

2023-04-12·Infectious diseases of poverty

Driving role of climatic and socioenvironmental factors on human brucellosis in China: machine-learning-based predictive analyses.

Article

作者: Song, Hong-Bin ; Huang, Yin-Xiang ; Wang, Lei ; Wang, Li-Gui ; Fang, Li-Qun ; Feng, Yao ; Chen, Hui ; Wang, Li-Ping ; Lin, Meng-Xuan

BACKGROUNDBrucellosis is a common zoonotic infectious disease in China. This study aimed to investigate the incidence trends of brucellosis in China, construct an optimal prediction model, and analyze the driving role of climatic factors for human brucellosis.METHODSUsing brucellosis incidence, and the socioeconomic and climatic data for 2014-2020 in China, we performed spatiotemporal analyses and calculated correlations with brucellosis incidence in China, developed and compared a series of regression and Seasonal Autoregressive Integrated Moving Average X (SARIMAX) models for brucellosis prediction based on socioeconomic and climatic data, and analyzed the relationship between extreme weather conditions and brucellosis incidence using copula models.RESULTSIn total, 327,456 brucellosis cases were reported in China in 2014-2020 (monthly average of 3898 cases). The incidence of brucellosis was distinctly seasonal, with a high incidence in spring and summer and an average annual peak in May. The incidence rate was highest in the northern regions' arid and continental climatic zones (1.88 and 0.47 per million people, respectively) and lowest in the tropics (0.003 per million people). The incidence of brucellosis showed opposite trends of decrease and increase in northern and southern China, respectively, with an overall severe epidemic in northern China. Most regression models using socioeconomic and climatic data cannot predict brucellosis incidence. The SARIMAX model was suitable for brucellosis prediction. There were significant negative correlations between the proportion of extreme weather values for both high sunshine and high humidity and the incidence of brucellosis as follows: high sunshine, [Formula: see text] = -0.59 and -0.69 in arid and temperate zones; high humidity, [Formula: see text] = -0.62, -0.64, and -0.65 in arid, temperate, and tropical zones.CONCLUSIONSSignificant seasonal and climatic zone differences were observed for brucellosis incidence in China. Sunlight, humidity, and wind speed significantly influenced brucellosis. The SARIMAX model performed better for brucellosis prediction than did the regression model. Notably, high sunshine and humidity values in extreme weather conditions negatively affect brucellosis. Brucellosis should be managed according to the "One Health" concept.

2022-12-01·International Journal of Antennas and Propagation

Analysis of Shielding Effectiveness of the Cavity Built with Single-Layer Reinforced Concrete

作者: Huang, Liuhong ; Li, Yuebo ; Yang, Jie ; Xiong, Jiuliang ; Wei, Bing ; Sun, Xiangang

In view of the existing literature mainly studying the situation of infinite reinforced concrete structure, the shielding effectiveness of three-dimensional single-layer reinforced concrete cavity is studied by considering the structural parameters of steel and the electromagnetic parameters of the concrete. The influence of structure parameters of steel mesh size, the steel diameter, and electromagnetic parameters of concrete dielectric coefficient, conductivity and moisture content on shielding effectiveness of reinforced concrete are analyzed. The research shows that the shielding effectiveness of the reinforced concrete cavity structure has resonance characteristics, and the increase of concrete conductivity and moisture content weaken the resonance characteristics of it so that the shielding effectiveness of the reinforced structure is improved. The results of this paper have a reference value for the analysis of shielding effectiveness of the single-layer reinforced concrete cavity in different practical situations.

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