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更新于：2025-06-24
University of Bradford
更新于：2025-06-24
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NCT05955638
Management of Myopia in University Students Using Dual Focus Soft Contact Lenses
ISRCTN10653250
Social care planning and provision for people with young onset dementia and their families: current practice and resources for improvement
ISRCTN23294745
Developing interventions and investigating molecular markers of age-related sarcopenia
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2025-12-31Health Psychology and Behavioral Medicine
Optimising data sharing whilst protecting participant privacy: a data note describing processed data from a qualitative study of healthcare professionals’ experiences of caring for women with false positive screening test results
Article
作者: Long, Hannah A. ; Branney, Peter ; Brooks, Joanna M. ; French, David P.
Introduction:
The present article describes the processed data generated in a qualitative interview study and template analysis. Many women find the experience of being recalled and receiving a false-positive breast screening test result to be distressing. The interview study aimed to understand breast screening healthcare professionals' (HCPs) experiences of providing care during the recall process and when receiving false-positive screening test results, including their communication with women around false-positive screening test results.
Methods:
Twelve HCPs from a single screening unit in the English National Health Service Breast Screening Programme participated in semi-structured interviews in 2020. All participants were female. A range of HCPs roles were recruited, including advanced radiographer practitioners, breast radiographers, breast radiologists, clinical nurse specialists, and radiology healthcare assistants. The data were analysed thematically using template analysis from a limited realist perspective.
Results:
A total of 20 data files are described, reflecting the iterative nature of template analysis. The files report various versions of codes, subthemes, themes, and every template produced during analysis. The files are publicly available on the Open Science Framework and UK Data Service (ReShare).
Discussion:
This data note outlines our approach to conducting a template analysis of qualitative data while protecting highly identifiable data, which is stored in a non-public archive and only available to the study team. It offers a practical, worked example of the template analysis process, thereby providing a detailed illustration beyond the concise summaries typically found in published reports, and complementing methodological papers of template analysis.
2025-12-31Journal of Immunotoxicology
Immunophenotypical characterization of immune checkpoint receptor expression in cynomolgus monkeys and human healthy volunteers in resting and in T-cell stimulatory conditions
in vitro
Article
作者: Cadwallader, Karen ; Rowse, Amber ; Fortunato, Mara ; Munday, James ; Morgado, Sara ; Yarzabek, Brogan ; McGee, Karen ; Perkins, Ethan ; Cooper, Chris ; Cocco, Mario ; Hollenbaugh, Joseph A. ; Lapinski, Philip ; Craig-Meyer, Danielle
Immunotherapeutics targeting immune checkpoint receptors or their ligands (i.e., immune checkpoint inhibitors), have been groundbreaking in the field of oncology, radically changing the approach to treatment and improving the clinical outcomes of an ever-expanding list of solid tumors and hematological malignancies. However, immune checkpoint inhibitors (ICI) are not devoid of side effects, collectively regarded as immune-related adverse events (irAE); they are not easily uncovered in preclinical immunotoxicological investigations and are often due to the very low expression of their targets in immunologically-unchallenged non-clinical species. We have characterized expression of a broad range of immune checkpoint receptors in peripheral blood mononuclear cell (PBMC) subpopulations from cynomolgus monkeys and healthy human volunteers, under resting and T-cell stimulatory conditions by multicolor flow cytometry to inform appropriate species selection for modeling potential irAE in immunotherapeutic preclinical research. Focusing on the response of the main lymphocyte populations to interleukin (IL)-2 alone, or in combination with anti-CD3 and anti-CD28 antibodies, checkpoints with shared similarities and key differences between the two species were identified. The results of this first study provide a database for the expression and response to stimulation for immune checkpoint receptors and can help guide future model selection in the design of preclinical studies involving immunotherapeutics directed against these targets.
2025-08-01MICROBIAL PATHOGENESIS
Bee products in the fight against Helicobacter pylori and molecular interactions
Review
作者: El-Seedi, Hesham R ; Refaey, Mohamed S ; El-Seedi, Shaden H ; Guo, Zhiming ; Abd El-Wahed, Aida A ; Liu, Lianliang ; Khalifa, Shaden A M ; Albadawy, Aida ; Zou, Xiaobo ; Abolibda, Tariq Z ; Cheng, Guiguang ; Salem, Mohamed F ; Karav, Sercan ; Tang, Jie
Gastric or duodenal ulcers can lead to upper gastrointestinal (GI) bleeding. Infection with Helicobacter pylori (H. pylori) is one of the most common infections in the world and can cause both gastric ulcers and gastric cancer. The treatment aims to eradicate H. pylori and treatment with antibiotics has made it possible to cure gastric ulcers. The most common complication of untreated peptic ulcer disease is bleeding (hematemesis, melena, and anemia), while perforation occurs in a smaller proportion of patients. In some individuals, the infection causes mucosal changes with increasing age that lead to atrophy and intestinal metaplasia. It is believed that atrophy and especially intestinal metaplasia are a prerequisite for the most common form of gastric cancer, adenocarcinoma. There is presently a demand for an alternate treatment devoid of the current strategies drawbacks including recurrence, resistance and antibiotic abuse. The current workhighlights the possibility of bee product-based treatments for preventing and eliminating H. pylori infestation. Sci-finder, Google Scholar, PubMed, ScienceDirect, Web of Science, and Scopus were used for literature screening. Terms and keywords, i.e. "helicobacter pylori", "epidemiology", "chemotherapy", "honey", "propolis", "bee venom", "bioactive compounds", and "mechanism of action" were used in the search. Bee products are important alternatives that have been utilized for treating many ailments due to their diverse biochemical and biological characteristics. Various mechanisms, such as direct antibacterial, antioxidant, anti-inflammatory, and wound healing capacities, are proposed to explain the potential effect of bee products against H. pylori. The bee product's metabolites have a role in the adherence of H. pylori to stomach epithelial cells. The disruption of bacterial cell membranes and the inhibition of virulence factors are the two mechanisms behind the bee product's promising therapeutic applications against H. pylori.
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