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项与 FUJIFILM RI Pharma Co., Ltd. 相关的药物

Iometopane

碘[123]苯托烷

靶点

DAT

作用机制

DAT拮抗剂 [+1]

在研机构-

原研机构

Research Triangle Institute

在研适应症-

非在研适应症

帕金森病

最高研发阶段终止

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100 项与 FUJIFILM RI Pharma Co., Ltd. 相关的临床结果

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0 项与 FUJIFILM RI Pharma Co., Ltd. 相关的专利（医药）

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39

项与 FUJIFILM RI Pharma Co., Ltd. 相关的文献（医药）

2020-08-01·Journal of Nuclear Cardiology3区 · 医学

Noninvasive estimation of quantitative myocardial blood flow with Tc-99m MIBI by a compartment model analysis in rat

3区 · 医学

Article

作者: Fujimoto, Osuke ; Okizaki, Atsutaka ; Koike-Satake, Miho ; Nakahara, Yuto ; Nakajima, Kaori ; Oshikiri, Shinobu ; Nakayama, Michihiro

BACKGROUNDWe aimed to investigate the use of dynamic cardiac planar images to estimate myocardial blood flow (MBF) by a compartment model analysis using time-to-peak (TP) map and compared it by the microsphere technique in rat. Positron emission tomography is considered the gold standard method, but is not available everywhere. By contrast, although myocardial perfusion imaging (MPI) with single-photon tracers is more widely available, it may be difficult to obtain adequate region of interest (ROI) settings. We proposed using the TP map to set the ROI, and hypothesized that this method could facilitate the measurement of absolute MBF by MPI in rat.METHODSTwenty-one normal rats were studied. Dynamic planar images with Tc-99m MIBI were obtained, and input function and cardiac ROIs were set using the obtained TP map. MBF was estimated by a one-compartment model analysis with the Renkin-Crone model and by the microsphere technique.RESULTSThe MBFs from these two methods were significantly correlated. A negative proportional bias was observed, but no significant difference was observed between the mean MBFs calculated with each method.CONCLUSIONSMBF estimation by a compartment model analysis using TP map could facilitate absolute MBF measurement in rats.

2019-01-31·International Heart Journal4区 · 医学

Successful Inflammation Imaging of Non-Human Primate Hearts Using an Antibody Specific for Tenascin-C

4区 · 医学

Article

作者: Yasutomi, Yasuhiro ; Yoshida, Toshimichi ; Kurosawa, Hiroyuki ; Fujimoto, Ousuke ; Hiroe, Michiaki ; Imanaka-Yoshida, Kyoko ; Ageyama, Naohide ; Arano, Yasushi ; Uehara, Tomoya

Inflammation after myocardial infarction (MI) may be a major factor influencing ventricular remodeling, leading to congestive heart failure and arrhythmia. Therefore, inflammation in the heart needs to be monitored. Tenascin-C (TNC) is an extracellular matrix molecule not normally expressed, but it is strongly upregulated when associated with active inflammation. Based on this characteristic, we successfully imaged in vivo inflammatory lesions in rat models using ¹¹¹Indium (¹¹¹In)-labeled anti-TNC antibodies. The aim of the present study was to further assess the applicability of this molecular imaging probe to detect inflammatory activity in primate hearts.We generated an MI model of cynomolgus monkeys (Macaca fascicularis) by coronary artery ligation and performed dual-isotope single-photon emission computed tomography (SPECT) imaging with an ¹¹¹In-labeled anti-TNC antibody Fab' fragment (¹¹¹In-TNC Fab') and ^99mtechnetium methoxy-isobutyl isonitrile (^99mTc-MIBI). Dual autoradiography was used to compare the uptake of ¹¹¹In-TNC Fab' with histology and immunostaining for TNC. Dual-isotope SPECT showed the regional myocardial uptake of ¹¹¹In-TNC Fab' complementary to a defect in the perfusion image by ^99mTc-MIBI. The high radioactivity of ¹¹¹In-TNC Fab' by autoradiography corresponded to immunostaining for TNC, which was observed in inflammatory lesions at the border zone between the infarcted and non-infarcted areas of the left ventricle and at the epi/pericarditis lesions of the right ventricle. These results demonstrate the potential of ¹¹¹In-TNC-Fab' imaging to monitor myocardial injury and inflammation and suggest the feasibility of the non-invasive detection of cardiac inflammation following acute MI in a preclinical stage before testing in humans.

2018-04-01·Annals of Nuclear Medicine

Manual on the proper use of lutetium-177-labeled somatostatin analogue (Lu-177-DOTA-TATE) injectable in radionuclide therapy (2nd ed.)

Article

作者: Kinuya, Seigo ; Hosono, Makoto ; Hatazawa, Jun ; Ikebuchi, Hideharu ; Sugano, Hiroyasu ; Nakamura, Yoshihide ; Yanagida, Sachiko ; Kojima, Kiyotaka ; Inoue, Tomio ; Kitaoka, Asami ; Nakamura, Nobutaka ; Yamada, Takahiro

Here we present the guideline for the treatment of neuroendocrine tumors using Lu-177-DOTA-TATE on the basis of radiation safety aspects in Japan. This guideline was prepared by a study supported by Ministry of Health, Labour, and Welfare, and approved by Japanese Society of Nuclear Medicine. Lu-177-DOTA-TATE treatment in Japan should be carried out according to this guideline. Although this guideline is applied in Japan, the issues for radiation protection shown in this guideline are considered internationally useful as well. Only the original Japanese version is the formal document.

100 项与 FUJIFILM RI Pharma Co., Ltd. 相关的药物交易

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100 项与 FUJIFILM RI Pharma Co., Ltd. 相关的转化医学

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