This project, called Memory for Music, focuses on the increasing number of people worldwide living with dementia, especially Alzheimer's disease (AD). AD typically starts with memory problems and eventually affects daily activities. Active music interventions, especially singing, have shown positive effects on mood, behavior, and quality of life for people with dementia, but their impact on cognition is not well understood. The project aims to address this gap by studying the effects of learning new songs on cognitive, behavioral, and brain functioning.
The study will involve home-dwelling adults aged 65 or older with AD from Argentina, Austria, and Norway. Participants will undergo 5 months of intensive musical training (twice a week) and 5 months of minimal training (once a month) in a random order, with a 2-month break in between. The interventions include learning new songs with a personal music teacher. General cognition will be measured using the Alzheimer's Disease Assessment Scale - Cognitive (ADAS-cog), and memory for music will be assessed through various methods, including behavioral tasks and brain responses (EEG). Mood will also be evaluated in each session.
The goal is to include 113 participants to ensure reliable detection of meaningful effects. The study will explore how mood and memory for music contribute to changes in cognitive abilities, and whether these effects vary based on factors such as sex, age, AD stage, or previous musical training and general education. The project emphasizes collaboration between researchers, service providers, and users to ensure the study's relevance and applicability.

开始日期2024-10-01

申办/合作机构

Norce Norwegian Research Centre AS

[+3]

NCT06592677 / Not yet recruitingN/AIIT

Early Support After Exposure to Trauma

A significant proportion of people who are exposed to traumatic events suffer from post-traumatic sequelae, such as post-traumatic stress disorder (PTSD). Indicated preventive interventions soon after trauma could be appropriate. Yet, there is limited evidence for the efficacy of such interventions. Moreover, no evidence-based preventive interventions are readily available for victims in the aftermath of crises and disasters in Norway. Condensed Internet-delivered Prolonged Exposure (CIPE) is a preventive intervention designed for victims with symptoms of PTSD (PTSS) approximately one month after a traumatic event. The treatment is an internet-delivered, therapist assisted intervention, based on principles from Prolonged Exposure. CIPE has proven to be feasible, safe, and effective in previous studies. This study aims to test the effectiveness and cost-effectiveness of CIPE in the context of psychosocial crisis services in Norwegian municipalities.
Hypotheses Effectiveness H1 Participants receiving CIPE + treatment as usual (TAU) will have significantly less PTSS than participants receiving TAU at 2.5-, 6-, and 12- months after the traumatic incident.
H2 Significantly fewer participants receiving CIPE+TAU will fulfill the criteria for PTSD than participants receiving TAU, at 6- and 12-months post trauma.
H3 Participants receiving CIPE+TAU will have significantly less symptoms of depression and insomnia than participants receiving TAU at 2.5-, 6-, and 12- months after the traumatic incident.
H4 Participants in the CIPE+TAU-condition will report significantly higher treatment satisfaction at post-treatment, compared to those in the TAU-condition.
H5 Participants with traumatic loss receiving CIPE+TAU will have significantly less symptoms of prolonged grief than such participants receiving TAU 12 months after the loss.
Cost-effectiveness H6 Fewer participants in the CIPE+TAU-condition will be referred to second-tier specialty mental health services, and more will achieve improved quality of life within the first year after the traumatic incident, compared to participants in the TAU-condition.
H7 The CIPE+TAU implementation is more cost-effective compared to the TAU in the short run and may even dominate TAU in the long run (i.e., more effective and less costly).

开始日期2024-09-13

申办/合作机构

Noregs forskingsråd

[+2]

NCT06040437 / RecruitingN/A

Be-Prox. An Effectiveness Study of Bullying Intervention in Norwegian Kindergartens.

With an overall aim to ensure a safe and sound kindergarten environment for all Norwegian children in accordance with the Kindergarten Act §§41-43, the objectives of the current project are:
To evaluate the effectiveness of Be-Prox Norway to prevent and handle negative behavior and bullying among peers in Norwegian kindergartens.
To examine implementation factors that promote and inhibit the effectiveness of Be-Prox Norway in Norwegian kindergartens.
To describe the cost-effectiveness of the Be-Prox Norway intervention in Norwegian kindergartens.
To generate knowledge on how the Be-Prox Norway intervention can be aligned and implemented in Norwegian kindergartens.

开始日期2023-08-07

申办/合作机构

Norce Norwegian Research Centre AS

[+1]

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项与 Norce Norwegian Research Centre AS 相关的文献（医药）

2024-10-15·Journal of Climate

Deciphering the Variations and Mechanisms of Global Land Monsoons during Marine Isotope Stage 3

作者: Guo, Chuncheng ; Zhang, Jinzhe ; Jiang, Nanxuan ; Yan, Qing

AbstractMarine Isotope Stage 3 (MIS 3) is characterized by significant millennial-scale climatic oscillations between cold stadials and mild interstadials, which presents a valuable case for understanding hydrological response to abrupt climate change. Through a set of coupled model simulations, our results broadly show an antiphased interhemispheric change in land monsoonal precipitation during the present-day relative to MIS 3 interstadial and the stadial–interstadial transition, with a general decrease in the Northern Hemisphere but an increase in the Southern Hemisphere. The antiphased pattern is largely caused by the change in orbital insolation during the present-day relative to MIS 3 interstadial, whereas by the weakened Atlantic meridional overturning circulation during the interstadial–stadial transition. However, there are obvious discrepancies in precipitation response and underlying mechanisms among individual monsoon domains and across different periods. Based on the moisture budget analysis, we indicate that the dynamic factor mainly explains the decreased monsoonal rainfall in the Northern Hemisphere during the present-day relative to the MIS 3 interstadial, whereas the thermodynamic term is largely responsible for the increased precipitation in the Southern Hemisphere. In contrast, the dynamic factor plays an important role in the variation of precipitation over all the monsoon zones from the MIS 3 interstadial to stadial states, with the thermodynamic term mainly contributing to the decreased tropical monsoonal precipitation in the colder Northern Hemisphere. Our results help improve the understanding of global monsoon variations under intermediate glacial climate conditions and shed light on their behaviors under potentially rapid climate change in the future.

2024-10-01·Science of The Total Environment

Greening of Svalbard

Article

作者: Karlsen, Stein Rune ; Høgda, Kjell Arild ; Elvebakk, Arve ; Macias-Fauria, Marc ; Stendardi, Laura

Svalbard, located between 76°30'N and 80°50'N, is among the regions in the world with the most rapid temperature increase. We processed a cloud-free time-series of MODIS-NDVI for Svalbard. The dataset is interpolated to daily data during the 2000-2022 period with 232 m pixel resolution. The onset of growth, with a clear phenological definition, has been mapped each year. Then the integrated NDVI from the onset (O) of growth each year to the time of average (2000-2022) peak (P) of growth (OP NDVI) have been calculated. OP NDVI has previously shown high correlation with field-based tundra productivity. Daily mean temperature data from 11 meteorological stations are compared with the NDVI data. The OP NDVI values show very high and significant correlation with growing degree days computed from onset to time of peak of growth for all the meteorological stations used. On average for the entire Svalbard, the year 2016 first had the highest greening (OP NDVI values) recorded since the year 2000, then the greening in 2018 surpassed 2016, then 2020 surpassed 2018, and finally 2022 was the year with the overall highest greening by far for the whole 2000-2022 period. This shows a rapid recent greening of Svalbard very strongly linked to temperature increase, although there are regional differences: the eastern parts of Svalbard show the largest variability between years, most likely due to variability in the timing of sea-ice break-up in adjacent areas. Finally, we find that areas dominated by manured moss-tundra in the polar desert zone require new methodologies, as moss does not share the seasonal NDVI dynamics of tundra communities.

2024-10-01·Environmental Values

A social and ethical game-changer? An empirical ethics study of CRISPR in the salmon farming industry

作者: Blix, Torill ; Myskja, Bjørn ; Myhr, Anne Ingeborg ; Holm, Lotte ; Winther, Hannah

The genome editing technology CRISPR is described as a technological game-changer because of its flexibility and precision, and as an ethical game-changer due to its ability to engineer traits in living organisms without crossing species, avoiding a significant objection to genetically modified organisms (GMOs). In salmon farming, applications of CRISPR in breeding hold the promise of handling environmental and fish welfare challenges yet require social acceptance. Adopting an empirical bioethics framework, this stakeholder interview study shows that respecting species borders is important, but not decisive, for acceptance among Norwegian stakeholders. The main objections are based on moral reflections about technology use and outcomes. These reflections combine principles and pragmatic deliberations of moral costs and benefits, suggesting that CRISPR applications with environmentally and ethically significant benefits can be socially acceptable. This indicates that the game-changing potential of CRISPR relies on the characteristics of the editing and the context in which the application takes place.

项与 Norce Norwegian Research Centre AS 相关的新闻（医药）

2014-09-09

·BioSpace

Sleep Deprivation May Shrink Your Brain, University of Oxford Study

Can Sleep Loss Affect Your Brain Size? MINNEAPOLIS – Sleep difficulties may be linked to faster rates of decline in brain volume, according to a study published in the September 3, 2014, online issue of Neurology® , the medical journal of the American Academy of Neurology. Sleep has been proposed to be “the brain’s housekeeper”, serving to repair and restore the brain. The study included 147 adults 20 and 84 years old. Researchers examined the link between sleep difficulties, such as having trouble falling asleep or staying asleep at night, and brain volume. All participants underwent two MRI brain scans, an average of 3.5 years apart, before completing a questionnaire about their sleep habits. A total of 35 percent of the participants met the criteria for poor sleep quality, scoring an average of 8.5 out of 21 points on the sleep assessment. The assessment looked at how long people slept, how long it took them to fall asleep at night, use of sleeping medications, and other factors. The study found that sleep difficulties were linked with a more rapid decline in brain volume over the course of the study in widespread brain regions, including within frontal, temporal and parietal areas. The results were more pronounced in people over 60 years old. “It is not yet known whether poor sleep quality is a cause or consequence of changes in brain structure,” said study author Claire E. Sexton, DPhil, with the University of Oxford in the United Kingdom. “There are effective treatments for sleep problems, so future research needs to test whether improving people’s quality of sleep could slow the rate of brain volume loss. If that is the case, improving people’s sleep habits could be an important way to improve brain health.” The study was supported by Research Council of Norway, the U.K, National Institute for Health Research, Wellcome Trust, Norwegian Research Council, European Research Council and University of Oslo. To learn more about brain health, please visit . The American Academy of Neurology, an association of more than 28,000 neurologists and neuroscience professionals, is dedicated to promoting the highest quality patient-centered neurologic care. A neurologist is a doctor with specialized training in diagnosing, treating and managing disorders of the brain and nervous system such as Alzheimer’s disease, stroke, migraine, multiple sclerosis, concussion, Parkinson’s disease and epilepsy. For more information about the American Academy of Neurology, visit or find us on Facebook , Twitter, Google+ and YouTube . Hey, check out all the research scientist jobs. Post your resume today!

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100 项与 Norce Norwegian Research Centre AS 相关的转化医学

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