The objective of this clinical trial is to determine whether cognitive functional therapy is superior to therapeutic exercises for the treatment of chronic shoulder pain. The main questions it aims to answer are:
Is cognitive functional therapy superior to therapeutic exercises for pain and disability in individuals with chronic shoulder pain? Is cognitive functional therapy superior to therapeutic exercises for functionality and psychosocial factors?
Participants will:
Receive 4 to 8 sessions of cognitive functional therapy once a week for four to eight weeks.
Follow a therapeutic exercise protocol for eight weeks with a frequency of twice per week.

开始日期2025-04-01

申办/合作机构

Universidade Federal de São Carlos

NCT06259344

/ Not yet recruitingN/AIIT

Effect of Pain Science Education Administered in Full or Fractioned Dosage Modes Associated With Conventional Treatment on Pain Intensity and Disability for Temporomandibular Disorders: a Randomized Controlled Trial

Temporomandibular Disorders (TMD) are a collection of musculoskeletal disorders which affect the masticatory structures and have a multifactorial etiology. A biopsychosocial approach is recommended for the management of these disorders including different interventions like exercise, manual therapy and pain education. The aim of this study is to compare the effect of a full dosage mode pain science education program (2 initial sessions of 45 minutes) versus a fractioned dosage format (6 sessions of 15 minutes) combined with manual therapy and orofacial exercises on primary outcomes - pain intensity and disability - and secondary outcomes - mandibular range of motion, pain-related self-efficacy, kinesiophobia, global perception of improvement, empathy, knowledge about pain neuroscience, beliefs about pain, exercise adherence, and catastrophizing - in patients with chronic painful TMD. This study will be a randomized controlled trial with a sample of 148 participants. Individuals will undergo a screening process to identify those with TMD diagnosis according to the Diagnostic Criteria for Temporomandibular Disorders (DC/TMD), aged 20 to 60 years, of both genders, and then the volunteers will be randomized into two groups (G1: Full dosage mode pain science education program + Manual therapy/orofacial and neck motor exercises vs. G2: Fractioned dosage mode pain science education program + Manual therapy/orofacial and neck motor exercises). These volunteers will be recruited in the city of São Carlos, SP. The intervention will take place twice a week for 8 weeks, administered by a single therapist, each session lasting 1 hour. The primary outcomes will be pain intensity and disability, assessed using the numerical pain rating scale and the Craniofacial Pain and Disability Inventory (CFP-DI), respectively, and the secondary outcomes will be mandibular range of motion, pain-related self-efficacy, kinesiophobia, global perception of improvement, empathy, knowledge about pain neuroscience, beliefs about pain, exercise adherence, and catastrophizing, assessed using the Tampa Scale for Kinesiophobia for Temporomandibular Disorders (TSK-TMD), Global Perceived Effect of Improvement scale, Pain Self-Efficacy Questionnaire (PSEQ), CARE Empathy Scale, and Pain Catastrophizing Scale (PCS). For statistical analysis, a Generalized Estimated Equations considering time and groups as factors will be used. A significance level of p<0.05 will be considered.

开始日期2024-09-01

申办/合作机构

Universidade Federal de São Carlos

RBR-2f836zh

/ Active, not recruitingN/AIIT

Effects of different weekly volume progressions of Resistance Training morphological adaptations of trained young adults: a controlled, randomized, within-subject study

开始日期2024-07-01

申办/合作机构

Universidade Federal de São Carlos

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项与 Universidade Federal de São Carlos 相关的文献（医药）

2025-12-01·Medical Gas Research

Hyperbaric oxygen therapy alleviates intestinal and brain damage in experimental necrotizing enterocolitis

Article

作者: Marques, Pamella S. B. ; Lopes, Luiza S. ; Feres, Omar ; Sbragia, Lourenco ; da Silva-Tomaeli, Stephanya C. ; Marsico, Ana Laura

Necrotizing enterocolitis is the most common gastrointestinal emergency in newborns. Its etiology involves bacterial colonization, enteral formula feeding, and hypoxic-ischemic injury. The pathology of necrotizing enterocolitis is characterized by coagulation necrosis and bacterial overgrowth, with limited preventative methods available. In addition to affecting the intestine, this disease has long-term neurological consequences for survivors. Hyperbaric oxygen therapy, a well-established treatment for soft tissue infections and injuries caused by hypoperfusion, may serve as an alternative approach for necrotizing enterocolitis. In this study, a necrotizing enterocolitis model was developed in newborn Sprague–Dawley rat pups through the administration of a hyperosmolar formula, combined with exposure to hypothermia and hypoxia. The rat pups received hyperbaric oxygen therapy sessions at 3 absolute atmospheres for 2 hours each, which were administered over 1 or 2 days. The results demonstrated that hyperbaric oxygen therapy significantly reduced mortality in rats with necrotizing enterocolitis and preserved the number of brain cells in the hippocampus. Additionally, hyperbaric oxygen therapy increased the expression of nitric oxide synthase, intestinal fatty acid-binding protein, and superoxide dismutase 3 in the intestine, and elevated superoxide dismutase 3 levels in the hippocampus. These findings suggest that hyperbaric oxygen therapy not only reduces mortality but also mitigates the severity of intestinal and brain lesions in experimental necrotizing enterocolitis, preserving intestinal cell integrity and enhancing antioxidant mechanisms.

2025-11-01·TALANTA

Electrochemical genomagnetic assay for detection of SARS-CoV-2 RNA using a disposable microfluidic platform

Article

作者: Pott-Junior, Henrique ; Faria, Ronaldo Censi ; Sabino, Ester Cerdeira ; Almeida Dos Santos, Daniel Júnior ; Melendez, Matias Eliseo ; de Oliveira, Tássia Regina

BACKGROUND:

The COVID-19 pandemic exposed the world to one of the greatest challenges in our history, causing profound social and economic impacts. With the advance of the pandemic, it became evident that there was a need for new diagnostic tests for monitoring and controlling the disease. In this sense, we describe the development of a genomagnetic assay based on the use of a fully disposable electrochemical microfluidic device for detection of RNA from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in saliva samples.

RESULTS:

A simple and low-cost disposable microfluidic platform (DμP) containing unmodified carbon-based electrodes was developed and coupled to a 3D holder containing neodymium magnets for detection of SARS-CoV-2 RNA in saliva samples. The device allows up to 8 simultaneous detections using the genomemagnetic assay, providing sensitivity with a limit of detection of 0.44 fmol L^-1 and a limit of quantification of 1.44 fmol L^-1, with a linear range of 5.0 fmol L^-1 to 200.0 nmol L^-1. The proposed assay has been successfully applied for the diagnosis of COVID-19 in cohorts of positive and negative individuals, showing excellent agreement with the results obtained by reverse transcription-polymerase chain reaction (RT-PCR). The genomagnectic assay showed the ability to discriminate between healthy individuals and patients infected with SARS-CoV-2, showing 82.4 % and 100.0 % of clinical sensitivity and specificity, respectively.

SIGNIFICANCE:

The method developed allows a simple, low-cost, and quantitative detection of viral RNA requiring no transcription or DNA amplification steps showing excellent reproducibility. The genomagnetic assay proposed can be an alternative tool for the diagnosis and monitoring of COVID-19 and even could be easily adapted for detection of other single-stranded RNA viruses.

2025-09-01·Physiotherapy

A systematic review and meta-analysis of the effectiveness of high-intensity laser therapy in patients with carpal tunnel syndrome

Review

作者: de la Barra Ortiz, Hernán Andrés ; Parizotto, Nivaldo Antonio ; Avila, Mariana Arias ; Liebano, Richard Eloin

OBJECTIVES:

This systematic review aimed to evaluate the effects of high-intensity laser therapy (HILT) on pain intensity, disability, and electrophysiological parameters in individuals diagnosed with carpal tunnel syndrome (CTS).

DATA SOURCES AND SYNTHESIS:

A search of electronic databases, including PubMed, Web of Science, Scopus, CINAHL, Science Direct, Cochrane Library, the PEDro database, and Google Scholar (updated until February 18, 2025), was conducted for randomized controlled trials (RCTs).

DATA EXTRACTION AND QUALITY ASSESSMENT:

Data were extracted independently by three researchers. The quality of RCTs was assessed using the Cochrane Risk of Bias (RoB) 2.0 tool, while evidence certainty was evaluated with the GRADE approach. Primary outcomes included pain intensity, with secondary outcomes comprising electrophysiological parameters and disability.

RESULTS:

Nine RCTs met inclusion criteria. Most studies exhibited a low risk of bias across RoB2 domains, except for outcome measurement, resulting in an overall RoB of 44%. Meta-analyses demonstrated that HILT, alone or combined with interventions such as splinting, exercise, TENS, vitamin B supplements, or ergonomic modifications, significantly reduced pain (SMD = 0.7 to 1.6) and disability (SMD = 0.68). Electrophysiological improvements included enhanced distal motor latency (SMD = 0.98) and sensory conduction velocity (SMD = 0.8), particularly when combined with median nerve gliding or splinting.

CONCLUSION:

This review confirms HILT's effectiveness in reducing pain and disability and improving electrophysiological parameters in CTS. However, evidence certainty remains moderate to low. Future RCTs should standardize outcome measures to evaluate HILT's clinical impact beyond statistical significance, and comparative studies with LLLT are needed to refine laser therapy protocols.

SYSTEMATIC REVIEW REGISTRATION NUMBER:

PROSPERO CRD42023470170 (October 17, 2023). CONTRIBUTION OF THE PAPER.

项与 Universidade Federal de São Carlos 相关的新闻（医药）

2024-12-02

·drugs

Pain + Depressive Symptoms Increase Risk for Cognitive Decline

MONDAY, Dec. 2, 2024 -- The coexistence of moderate-to-intense pain and depressive symptoms is a risk factor for the decline of global cognition and memory, according to a study recently published in Aging & Mental Health . Patrícia Silva Tofani, Ph.D., from the Federal University of Sergipe in Brazil, and colleagues assessed whether the coexistence of pain and depressive symptoms is a risk factor for cognitive decline in individuals aged 50 years and older. The analysis included longitudinal data from 4,718 participants in the English Longitudinal Study of Ageing. The researchers found that during 12 years of follow-up, individuals with moderate/intense pain and depression had a greater memory decline (−0.038 standard deviation per year) and global cognition score (−0.033 standard deviation per year) compared with those with no pain and no depression. "It's relatively common for people to mistakenly attribute symptoms of depression and pain as normal factors of aging. And they're not," coauthor Tiago da Silva Alexandre, Ph.D., from the Federal University of São Carlos in Brazil, said in a statement. "This belief leads professionals who are not specialists in gerontology and geriatrics to minimize the complaints of older people in primary care and to fail to diagnose and treat modifiable conditions."

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