Amoxicillin multiple pulse pellet was prepared, and release was studied. Eudragit L30D-55, Eudragit L100 and Eudragit S100 were used as coating. 3% HPMC E5 and 1% EL-35 were wetting agent, CCNa was disintegrant, rolling 35 Hz, 4 min. Eudragit L30D-55 increased 24%, Eudragit L100 and Eudragit S100 increased 28%. Amoxicillin multiple pulse pellet release had multiple pulse effect.