The objective of this paper is to screen the optimum technol. for preparing Sodium Rabeprazole Enteric-Coated (Microgranules) Capsules.Sodium Rabeprazole Enteric-Coated (Microgranules) Capsules were prepared with extruding and air-flow coating methods.The influencing factors such as the concentration and consumption of HPMC liquid, used as binder, the consumption of microcrystalline cellulose were studied and each was arranged 3 levels according to L9(34) orthogonal table.The technol. was evaluated.Furthermore, 2 influencing factors, the consumptions of CaHPO4 and Na2HPO4, were studied which were also arranged 3 levels according to L9(34) orthogonal table.The increase of the relevant substances of the capsules which were kept in high temperature box for 10 d was used to evaluate their stability.The selected technique was validated by preparing a batch of Sodium Rabeprazole Enteric-Coated (Microgranules) Capsules.Their release was checked and their stability was tested via accelerated experiments, the sample products were compared with the same product from the market treated by the same way.The optimum technol. was that the core of the microgranules of each capsule included: sodium rabeprazole 10 mg, CaHPO4 40 mg, Na2HPO4 15 mg, microcrystalline cellulose 180 mg, the concentration of HPMC liquid was 4% and its consumption weighs 12% to initial total quality.The capsules had nearly no change in acid liquid while the dissolution was quick and complete in artificial intestinal liquidTheir stability was acceptable.The release and stability of the capsules were likely to the same product from the market.The selected technol. is practicable to prepare Sodium Rabeprazole Enteric-Coated (Microgranules) Capsules.