Mental and physical Fatigue and overall fatigue will be collected based on Fatigue assessment scale while balance data will be obtained by recording mobile sensors in X, Y and Z directions when mobile placed on COG of the participants.

开始日期2025-02-01

申办/合作机构

Kafrelsheikh University

NCT06551428

/ Not yet recruitingN/AIIT

The Sleep Stress Connection: Investigating How Sleep Quality Affects Mental and Physical Health

This study aimed to explore the relationship between sleep quality and its impact on mental and physical health, particularly in the context of stress.
A mixed methods approach will be used including:
a pre-test questionnaire and physiological measurements that depend on scales for measuring to assess sleep patterns: DASS21, fatigue assessment scale, Epworth sleeping scale, and SF-12 health survey scoring.
All of that will highlight the importance of addressing sleep quality as a crucial factor in promoting overall well-being.

开始日期2025-02-01

申办/合作机构

Kafrelsheikh University

NCT06757218

/ Not yet recruitingN/AIIT

Comparison of Autogenous Dentin Graft with Albumin Platelet Rich Fibrin Versus Autogenous Dentin Graft with Platelet Rich Fibrin in Alveolar Socket Preservation: a Randomized Controlled Clinical Trial.

The study focuses on the impact of tooth loss on alveolar bone, which shrinks significantly within the first three months. To prevent this, strategies like alveolar ridge preservation are used.
Autogenous dentin, taken from the patient, supports healing and bone regrowth. Platelet-rich fibrin (PRF), made from the patient's blood, enhances healing and bone density by releasing growth factors.
A new technique combining L-PRF with albumin creates a stable healing membrane that provides a steady release of growth factors. Overall, these methods improve recovery after tooth extractions and prepare sites for future dental work.

开始日期2025-01-01

申办/合作机构

Kafrelsheikh University

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6,453

项与 Kafrelsheikh University 相关的文献（医药）

2025-04-01·Veterinary Research Communications

A comparative study of the genetically improved Abbassa Nile tilapia strain (GIANT-G9) and a commercial strain in Egypt: growth vs. stress response

Article

作者: Said, Mohamed Mohamed ; Al Wakeel, Rasha A ; Bedir, Eman Ahmed ; Nasr-Allah, Ahmed M ; Abo-Al-Ela, Haitham G

AbstractSelective breeding is a potent method for developing strains with enhanced traits. This study compared the growth performance and stress responses of the genetically improved Abbassa Nile tilapia strain (G9; GIANT-G9) with a local commercial strain over 12 weeks, followed by exposure to stressors including high ammonia (10 mg TAN/L), elevated temperature (37 °C), and both for three days. The GIANT-G9 showed superior growth, including greater weight gain, final weight, length gain, specific growth rate, and protein efficiency ratio, as well as a lower feed conversion ratio and condition factor compared to the commercial strain. The expression of growth hormone in the brain of the GIANT‐G9 increased significantly after 6 weeks, although it slightly decreased after 12 weeks. Growth hormone receptor 1 expression also increased significantly after 6 weeks. Muscle insulin-like growth factors (igf1 and igf2) levels up-regulated significantly only after 12 weeks in the GIANT‐G9. Under stress, serum enzymes (alanine aminotransferase, aspartate aminotransferase, and alkaline phosphatase (ALP)) were significantly higher in the GIANT‐G9, while the commercial strain had lower levels. No significant changes were observed in liver ALP activity among stressed strains. Under stress, the GIANT‐G9 exhibited marked upregulation of splenic Toll-like receptors (tlr2, tlr9, tlr21), myeloid differentiation primary response protein 88 (myd88), nuclear factor kappa B (nf-κB), interleukin (il) 1β, and il6. Notably, il6 expression was higher than il1β in the spleen, with the opposite pattern in the head kidney. In response to immune stimulation, globulin levels significantly increased in the GIANT‐G9 but with similar values to the stressed commercial strain. Myostatin expression increased in the spleen of the stressed GIANT‐G9. The commercial strain exhibited the best liver catalase and superoxide dismutase activities under stress, while the GIANT‐G9 showed increased liver glutathione-S-transferase (GST) activity after exposure to ammonia and temperature stress. Serum lysozyme activity increased in the stressed commercial strain and under temperature stress in the GIANT‐G9 but decreased under other stress conditions. Overall, the stressed commercial strain demonstrated higher survivability than the stressed GIANT‐G9. The study revealed significant interactions between strains and stress factors. The GIANT‐G9 exhibited higher growth rates but lower antioxidant and immune capacities compared to the commercial strain at the juvenile stage of life and production cycle.

2025-04-01·Tissue and Cell

Platelet-rich plasma enhances remodeling of combined gastrocnemius muscle and Achilles tendon injuries in rat model: Reducing fibrosis, modulating gene (MMP9, Bax, HMGB1, and IGF) expression, and restoring histopathological and ultrastructural changes

Article

作者: Alhegaili, Alaa S ; Mahfouz, Hala ; Alsulimani, Ahmad ; Abdo, Walied ; Elmahallawy, Ehab Kotb ; Morsy, Manal Mohammad ; Salah, Basma ; Abouzed, Tarek Kamal ; Alnasser, Sulaiman Mohammed ; Hulail, Mohey E E ; Abdel-Kareem, Mona A ; Hakami, Zaki H

Muscle and tendon injuries are prevalent occurrences during sports activities. Platelet-rich plasma (PRP) is known for its rich content of factors essential for wound healing, inflammation reduction, and tissue repair. Despite its recognized benefits, limited information is available regarding PRP's effectiveness in addressing combined surgical injuries to the gastrocnemius muscle and Achilles tendon. The effects of PRP on muscle and tendon injury in rats were assessed through a set of biochemical markers, histopathological examinations, and immunohistochemistry analyses of muscular myogenin, desmin, and tendinous type I collagen. Additionally, mRNA expression levels of Matrix metalloproteinase-9 (MMP-9), Pro-apoptotic Bcl-2 Associated-X-protein (BAX), Insulin-like growth factor (IGF), and High mobility group box 1 protein (HMGB1) genes were evaluated. Induction of muscle and tendon injuries was associated with elevated levels of serum biomarkers such as C-reactive protein (CRP), Aspartate aminotransferase (AST), Lactate dehydrogenase A (LDH), and Creatine Kinase MB (CK-MB), delayed collagen fiber remodeling, and structural abnormalities in myofibrils. Furthermore, there was overexpression of MMP9, Bax, and HMGB1 genes, along with decreased expression of the IGF gene in this group. Treatment with PRP resulted in significant improvement of these reported findings, including enhanced collagen fiber remodeling, elevated levels of desmin and myogenin in muscle tissues, and increased expression of collagen type I in tendons. Additionally, PRP treatment led to reduced expression levels of MMP9, Bax, and HMGB1 genes, while the expression of the IGF gene increased. Overall, PRP treatment demonstrated substantial enhancement of the healing process in both muscle and tendon tissues in a surgical model of gastrocnemius skeletal muscle and Achilles tendon-induced injury. These findings suggest that PRP therapy may offer advantages in the treatment of physical-related injuries.

2025-04-01·Journal of Hazardous Materials

Nano-TiO2 impairs the health of crabs Charybdis japonica under warming conditions through waterborne and dietary exposures

Article

作者: Abo-Raya, Mohamed H ; Pang, Xiaopeng ; Tu, Zhihan ; El Amouri, Rim ; Hu, Menghong ; Wang, Youji

The widespread use of nano titanium dioxide (nano-TiO₂) poses ecological risks to marine ecosystems, especially when combined with ocean warming. However, most previous studies have only examined water-related exposures, leaving a gap in research on the impact of food transfer on organisms. In this work, the harmful impacts of nano-TiO₂ on the Japanese swimming crab Charybdis japonica were studied through three scenarios: direct exposure (DE) of the crabs to warming and nano-TiO₂, indirect exposure (IE) via consumption of thick-shelled mussels Mytilus coruscus exposed to the same conditions, and combined exposure (CE), where crabs were directly subjected to warming and nano-TiO₂ while feeding affected mussels. Moreover, a control group was established, consisting of Japanese swimming crab C. japonica and mussel M. coruscus that were raised under standard temperature (22 °C) and 0 mg L^-1 nano-TiO₂ concentration conditions. Immune, oxidative, and gene expression parameters were measured in gills and hepatopancreas after 7 exposure days. Furthermore, titanium bioaccumulation, along with the morphometrical and histological analyses, were assessed in gills. Bioaccumulation results (1.69-6.83 μg/g) suggested that foodborne stressors induced higher titanium contents. Additionally, there were deformities in gills morphometry and histology. The multivariate analyses showed that warming and nano-TiO₂ combination had a pronounced effect on the overall profile of biological responses in crabs; moreover, the exposure through food alone had the greatest impact on gills immune-oxidative parameters and hepatopancreas gene expressions. The harmful impacts of nano-TiO₂ are significant and can manifest through waterborne and dietary exposure pathways, especially when combined with other stressors, warranting further research.

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