EFFECTS OF MOXIFLOXACIN AND GEMIFLOXACIN ON BLOOD GLUCOSE LEVEL OF EUGLYCEMICS:A PRE-CLINICAL AND CLINICAL STUDY.
Our aim and objectives are to:
To check the possible effects of Moxifloxacin and Gemifloxacin in healthy volunteers for possible effects on blood glucose levels with a subsequent shift in serum insulin level of healthy volunteer (target population).
ECG morphology effect. In the above entitled studies we are going to determine the effects of the above two 4th generation fluoroquinolones drugs on the blood glucose levels and ECG morphology effect.of euglycemics healthy volunteers.The drug will be gave as per approved standard adult dose.The drug is FDA approved and marketed drug.No risk is to the patient only 3-5 ml of the blood will be taken at baseline and after the drug completion at steady state concentration.

开始日期2021-03-01

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Shaheed Benazir Bhutto University

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1,042

项与 Shaheed Benazir Bhutto University 相关的文献（医药）

2025-06-01·Steroids

Genetic insights into vitamin D deficiency: a case-control study of GC and CYP24A1 gene polymorphism

Article

作者: Mansour, Lamjed ; Ali, Aktar ; Khan, Aslam ; Abbas, Khurram ; Raza, Muhammad Kashif ; Usama ; Imran, Muhammad

Despite the sunny climate, vitamin D deficiency is highly prevalent in several parts of the world. Several risk factors are associated with VD deficiency, including single nucleotide polymorphism and post-translational modifications in its transport protein, known as vitamin D binding protein (DBP) or GC and CYP24A1, a protein associated with its degradation. Our study explores the impact of rs4588 and rs7041 in the GC gene, along with CYP24A1 rs4809960 and rs2585428, on serum vitamin D and the risk of vitamin D insufficiency. This study enrolled 114 healthy controls and 239 vitamin D-deficient subjects. SNPs were determined using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). The G/T genotype of D432E and the A/A genotype of T436K in the GC gene were observed to be risk factors for vitamin D deficiency. Overall, a significant (P < 0.05) association was observed between the D432E and T436K polymorphism and vitamin D deficiency. Polymorphic genotypes of CYP24A1 rs4809960 and rs2585428 polymorphisms were significantly associated with a higher risk of Vitamin D deficiency. D432E and T436K polymorphisms were associated with decreased vitamin D and increased PTH levels in vitamin D-deficient individuals. Similarly, both CYP24A1 polymorphisms were significantly associated with a higher risk of vitamin D deficiency. Also, a negative association was observed between sufficient serum levels of 25-hydroxyvitamin D and PTH levels.

2025-04-28·Pure and Applied Chemistry

Sequential sorption of crystal violet and emulsified oil onto poly(lauryl methacrylate-acrylamide) hybrid hydrogel

作者: Umar, Muhammad Naveed ; Ahmad, Hammad ; Alam, Sultan ; Gul, Zarif ; Shahat, Abdelaaty A. ; Shah, Luqman Ali ; Ullah, Riaz ; Zahoor, Muhammad ; Khan, Shehzad ; Haq, Izhar Ul ; Subhan, Hanif ; Uzma

AbstractThe operational industries continuously contribute significant volumes of synthetic dyes along with other pollutants into the aquatic environment. The global issue of dye induced water contamination was addressed through facile synthesis of hydrophobically associated poly(lauryl methacrylate-acrylamide) [p(LMA-AAm)] hydrogel by free radical polymerization method. The SEM (Scanning Electron Microscope) micrographs depicted suitability of the hybrid sorbent for crystal violet (CV) uptake owing to porous, rough and spongy texture. The fabricated sorbent was utilized for CV sorption by performing different tests like contact time, pH, and initial concentration effect on the CV sorption. The obtained kinetic and isothermal data fitted well into the non-linear versions of pseudo second order and Langmuir models respectively. The thermodynamics tests signified the sorption process of spontaneous and endothermic nature. After sorption, the resultant [CV/p(LMA-AAm)] waste was applied for toluene (oil probe) separation from water which performed excellent separation in the range of 83–74 % during the first three tests. Thus, the desirable sorption properties, facile fabrication and promising oil separation power may recommend the composite sorbent for applications in the relevant fields like water treatment, separation and sorption.

2025-04-08·Current Neuropharmacology

Conventional and Emerging Drug Targeting Sites in Alzheimer’s Disease and the Role of Translational Informatics in its Diagnosis and Management

Article

作者: Ullah, Abid ; Esa, Muhammad ; Hussain, Haya ; Kamal, Shah ; Kamal, Zul ; Ahmad, Shujaat ; Khan, Kashif Ali ; Perry, George ; Ullah, Bashir ; Shafique, Muhammad

Abstract:Alzheimer’s disease (AD), a neurodegenerative condition, continues to pose significant challenges to modern medicine due to the limited efficacy offered by current therapeutic modalities. With the complex pathophysiology of AD, which includes tau protein accumulation, amyloid-β plaque formation, neuroinflammation, and synaptic dysfunction, novel drug-targeting sites must be identified. This study presents a thorough evaluation of novel drug targeting sites, with a focus on these pathological characteristics as promising therapeutic targets while providing an explanation of their role in the course of the disease. We investigate in detail how neurotoxicity, resulting in synapse failure and cognitive impairment, is caused by tau proteins and amyloid plaques. In addition, the article discusses the increasing evidence that synaptic dysfunction is a major factor in the disease's progression, as well as the significance of neuroinflammation in the pathophysiology of the condition. The review also covers new drug sites such as amyloid-β plaques, tau proteins, and the inhibition of neuroinflammation mediators, in addition to traditional drug sites, including cholinergic and glutamatergic therapeutic targets. Lastly, we discuss the role of translational informatics involving data modeling, predictive analytics, explainable artificial intelligence (AI), and multimodal approaches for the management and prediction of AD. This article will serve as a guide for future research efforts in the fields of neuroscience, neuropharmacology, drug delivery sciences, and translational informatics.

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