Delving into the Latest Updates on 深圳市中核海得威生物科技有限公司 with Synapse

概览

疾病领域	数量

感染	1

排名前五的药物类型	数量

诊断用放射药物	1
小分子化药	1

关联

1

项与深圳市中核海得威生物科技有限公司相关的药物

Urea-13C

尿素C-13

靶点-

作用机制

PET imaging

在研机构

Richen Europe S.r.l.初创企业 [+3]

原研机构

Otsuka America Pharmaceutical, Inc.

在研适应症

诊断试剂 [+1]

非在研适应症-

最高研发阶段批准上市

首次获批国家/地区

美国

首次获批日期1996-09-17

3

项与深圳市中核海得威生物科技有限公司相关的临床试验

CTR20242271 / Recruiting临床3期

尿素[13C]呼气试验药盒用于诊断Hp感染的开放、随机、交叉、自身对照、多中心临床研究

验证尿素[13C]呼气试验药盒用于幽门螺杆菌诊断的有效性、安全性及与参比制剂对幽门螺杆菌诊断检测结果的一致性。

开始日期2024-07-17

申办/合作机构

深圳市中核海得威生物科技有限公司

CTR20233592 / CompletedN/A

尿素[13C]胶囊呼气试验药盒用于诊断Hp感染的开放、随机、交叉、自身对照、多中心临床研究

验证产品有效性及受试制剂与参比制剂对幽门螺杆菌诊断检测结果的一致性。

开始日期2023-11-10

申办/合作机构

深圳市中核海得威生物科技有限公司

CTR20180862 / Completed

尿素[14C]呼气试验药盒变更闪烁液溶剂临床研究

验证深圳市中核海得威生物科技有限公司生产药盒的变更闪烁液溶剂的临床诊断效果与原闪烁液溶剂一致。

开始日期2018-09-12

申办/合作机构

深圳市中核海得威生物科技有限公司

100 项与深圳市中核海得威生物科技有限公司相关的临床结果

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0 项与深圳市中核海得威生物科技有限公司相关的专利（医药）

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6

项与深圳市中核海得威生物科技有限公司相关的文献（医药）

2023-12-01·Science of The Total Environment

Fate and transformation of uniformly 14C-ring-labeled bisphenol S in different aerobic soils

Article

作者: Chen, Kai ; Jing, Qing ; Ding, Wenya ; Yu, Zhiyang ; Li, Juying ; Chen, Yan ; Chen, Yandao ; Wang, Haiyan ; Xu, Shengwei ; Guo, Longxiu ; Xu, Lei

Bisphenol S (BPS), being structurally similar to bisphenol A (BPA), has been widely used as an alternative to BPA in industrial applications. However, in-depth studies on the environmental behavior and fate of BPS in various soils have been rarely reported. Here, ¹⁴C-labeled BPS was used to investigate its mineralization, bound residues (BRs) formation and extractable residues (ERs) in three soils for 64 days. Significant differences were found in the dissipation rates of BPS in three soils with different pH values. The dissipation of BPS followed pseudo first-order kinetics with half-lives (T_1/2) of 15.2 ± 0.1 d, 27.0 ± 0.2 d, 180.4 ± 5.3 d, and 280.5 ± 3.3 d in the alkaline soil (fluvo-aquic soil, FS), the neutral soil (cinnamon soil, CS), the acidic soil (red soil, RS), and sterilized cinnamon soil (CS-S), respectively. The mineralization and BRs formation contributed the most to the dissipation of BPS in soil. BPS was persistent in acidic soil, and may pose a significant threat to plants grown in acidic soils. Additionally, soil microorganisms played a key role in BPS degradation, and the organic matter content might be a major factor that promotes the adsorption and degradation of BPS in soils. Two transformed products, P-hydroxybenzenesulfonic acid and methylated BPS were identified in soils. This study provides new insights into the fate of BPS in various soils, which will be useful for risk assessments of BPS in soil.

2023-05-01·Talanta

A visual diagnostic detection of Helicobacter pylori and the gastric carcinoma-related virulence genes (cagA and vacA) by a fluorescent loop-mediated isothermal amplification (LAMP)

Article

作者: Meng, Meng ; Wang, Bei ; Han, Quansheng ; Xi, Rimo ; Zhao, Xiujie ; Gan, Qi ; Munkhtsetseg, Baatar ; Zhang, Ruixiao ; Li, Chuanbing ; Qiao, Yanqi ; Zhang, Chunze ; Xu, Long ; Yin, Yongmei ; Bai, Su ; Tong, Yue ; Han, Mengfan

Helicobacter pylori (H. pylori) infection has increasingly been a serious problem worldwide. The H. pylori infection can result in a series of stomach diseases including gastric carcinoma. There are two specific virulence genes (cagA and vacA) of H. pylori that are closely related to the occurrence of gastric cancer, and the common molecular detection methods (PCR, qPCR) are not suitable for high-screening test due to the requirement of expensive instruments and well-trained personals. Herein, we develop a rapid visual assay based on loop-mediated isothermal amplification (LAMP) for detecting H. pylori and its major virulence genes (cagA, vacAs1 and vacAm1) to guide clinical treatment for H. pylori infection. In this research, a fluorescent LAMP assay was established by optimizing the indicator of MnCl₂-Calcein, so that the resulted color and fluorescence changes could be utilized to perform the visual detection for H. pylori and its virulence genes with high sensitivity (10^-3 ng/μL). The proposed LAMP assay is simple, fast (30 min) and capable in providing more sensitive results than traditional methods in the test of 46 clinical biopsy samples. By detecting the three virulence genes together, we can profile the infection risk of the patients, and discuss the correlation among the genes. Moreover, the method could be used to diagnose virulently infected individuals and benefit the eradication of H. pylori in early warning for gastric cancer.

2022-04-01·Journal of Breath Research3区 · 医学

Levitt’s CO breath test in the differential diagnosis of chronic isolated hyperbilirubinemia

3区 · 医学

Article

作者: Liu, Ze-Lin ; Liu, Ling-Wen ; Zhang, Hou-De ; Zhu, Guo-Liang ; Ji, Yong-Qiang ; Han, Quan-Sheng ; Chen, Yuan-Wu ; Ma, Yong-Jian ; Kang, Ling-Ling ; Ji, Kun-Mei ; Xie, Xian-Hui ; Luo, Jun-Feng

AbstractA key component of the differential diagnosis of isolated hyperbilirubinemia (HB) is distinguishing between hemolytic and non-hemolytic types. Routine hemolysis screening markers have unsatisfactory sensitivity and specificity. Erythrocyte (RBC) lifespan shortening, the gold standard marker of hemolysis, is seldomly measured due to the cumbersome and protracted nature of standard methods. A new Levitt’s CO breath test method may enable simple, rapid RBC lifespan measurement. In this pilot prospective diagnostic study, Levitt’s CO breath test was evaluated to discriminate hemolytic from non-hemolytic HB in adults. One hundred and thirty eligible non-smoking adult patients who were aged 18 or older, referred for chronic (>6 months) isolated HB or had a known diagnosis of isolated HB of a rare cause, were recruited, including 77 with non-hemolytic HB and 53 with hemolytic HB. ROC curve analysis was applied to determine the optimal cutoff for discriminating between hemolytic and non-hemolytic HB, and the performance was calculated. Results showed that the mean RBC lifespan in non-hemolytic HB (93 ± 26 d) was reduced (p = 0.001 vs. normal reference value of 126 d), but longer than that in hemolytic HB (36 ± 17 d; p = 0.001). RBC lifespans did not differ significantly between 26 patients with simple hemolytic HB (32 ± 14 d) and 27 patients with a Gilbert syndrome comorbidity (40 ± 18 d). ROC curve analysis revealed an optimal lifespan cutoff for discriminating between hemolytic and non-hemolytic HB of 60 d (AUC = 0.982), with a diagnostic accuracy of 95.4%, 94.3% sensitivity and 96.1% specificity respectively. These results indicate that Levitt’s CO breath test seems to be very sensitive and specific for detecting hemolysis in adult patients with chronic isolated HB, and could enable simple, rapid, and reliable differential diagnosis of isolated HB. A large-scale validation study of the method is warranted.

100 项与深圳市中核海得威生物科技有限公司相关的药物交易

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100 项与深圳市中核海得威生物科技有限公司相关的转化医学

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