Objective To explore the relationship between matrix metalloproteinase 14 (MMP-14) and matrix metalloproteinase 13 (MMP-13) and ventricular remodeling in patients with chronic heart failure (CHF). Methods A total of 83 patients with CHF admitted to the hospital from May 2019 to May 2021 were selected as the research objects. During the same period, 41 healthy patients were selected as the control group. The differences in the levels of MMP-14 and MMP-13, the differences in ventricular remodeling indexes, and the differences in the levels of MMP-14, MMP-13 and ventricular remodeling indexes in different cardiac function grades between the two groups of patients were compared, and the relationship between MMP-14, MMP-13 and ventricular remodeling in patients with CHF was analyzed. Results The levels of MMP-14 and MMP-13 in the observation group were significantly higher than those in the control group (P<0.05). The levels of MMP-14 and MMP-13 in patients with cardiac function grade IV were significantly higher than those in patients with cardiac function grade II and III (P<0.05). The levels of MMP-14 and MMP-13 in patients with cardiac function grade III were significantly higher than those in patients with cardiac function grade II (P<0.05). Left atrial diameter (LAD), left ventricular end diastolic diameter (LVDd), right ventricular diameter (RVD) and left ventricular mass index (LVMI) in the observation group were significantly higher than those in the control group (P<0.05), and left ventricular short axis shortening rate (LVFS), left ventricular ejection fraction (LVEF) were significantly lower than those in the control group (P<0.05). LAD, LVDd, RVD and LVMI of patients with cardiac function grade IV were significantly higher than those of patients with cardiac function grade II and III, and LVFS and LVEF were significantly lower than patients with cardiac function grade II and III (P<0.05). Pearson correlation anal. results showed that the levels of MMP-14 and MMP-13 were pos. correlated with LAD, LVDd, RVD, and LVMI (r>0, P<0.001), and neg. correlated with LVFS and LVEF (r>0, P<0.001). Conclusion There are abnormally high expressions of MMP-14 and MMP-13 in patients with CHF, the two are increased with the increase of cardiac functional grade, and they have significant correlation with ventricular remodeling.