Objective: To explore the correlation between blood lipid metabolism and individual differences in drug efficacy in hypertensive patients. Methods: A total of 390 patients with essential hypertension in our hospital were selected, all of them were treated with oral antihypertensive drugs, and the correlation anal. was carried out on the general data of the patients. Results: The total effective rate of treatment was 92.6%. After treatment, the systolic blood pressure, diastolic blood pressure, TC and LDL-C were lower than those before treatment (P<0.05), and there was no difference between TG and HDL-C (P>0.05). There was a correlation between drug efficacy and systolic blood pressure, diastolic blood pressure, TC, LDL-C, and alc. consumption (P<0.05), and systolic blood pressure, diastolic blood pressure, TC, LDL-C, and alc. consumption were the risk factors affecting drug efficacy (P<0.05) . Conclusion: Hypertensive patients are often accompanied by dyslipidemia, which is related to the prognosis of drug treatment. Systolic blood pressure, diastolic blood pressure, TC, LDL-C, and alc. consumption are the risk factors affecting the efficacy of drugs.