More than half of the Dutch population is overweight or obese, which is associated with an increased risk of COVID-19 and worse outcomes during a COVID-19 infection. In addition, malnutrition and loss of muscle mass are often reported with COVID-19, as well as with cancer and other diseases. Malnutrition and overweight or obesity can coexist, even within the same individual. It is still unclear which mechanisms contribute to the worse outcomes of COVID-19 and other diseases in case of overweight, malnutrition, and a combination of both. The aim of this study is to identify which parameters are associated with worse disease outcomes through literature research and database research (COVID-19 and cancer, more than 150.000 participants). In addition, a clinical study will be conducted aiming to develop a simple screening tool for the recognition of the coexistence of malnutrition and overweight or obesity in clinical practice.

开始日期2024-10-02

申办/合作机构

HAN University of Applied Sciences

[+4]

NCT06282757

/ Not yet recruitingN/A

The Effect of Physiotherapists' Placebo or Nocebo Communication About Virtual Reality on Treatment Beliefs in Patients With CMP

Rationale: Chronic musculoskeletal pain (CMP) is a common and disabling condition. Physiotherapy is the most frequently administered non-pharmacological treatment option for patients with CMP and recently virtual reality (VR) was introduced in physiotherapy care as a novel treatment modality. Proper communication about physiotherapy treatment (modalities) is important to improve treatment outcomes, by applying placebo effects enhancing communication and avoiding nocebo effects enhancing communication. However, yet is still unknown to what extent this applies to communication of physiotherapists about VR in patients with CMP.
Objective: To determine the effect of physiotherapists' placebo or nocebo therapeutic communication about VR, on treatment credibility and expectation in patients with CMP
Study design: Web-based randomized controlled trial.
Study population: 100 participants
Intervention: The placebo intervention group will be shown an educational video about VR, containing placebo effects enhancing verbal language. The nocebo intervention group will be shown an educational video about VR, containing nocebo effects enhancing verbal language.
Primary study parameters: The primary study parameters are treatment credibility and treatment expectation. Treatment credibility and treatment expectations will be measured using the Dutch credibility and expectancy questionnaire (CEQ).

开始日期2024-04-01

申办/合作机构

HAN University of Applied Sciences

NL-OMON53210

/ RecruitingN/A

The effect of collagen supplementation on human tendon protein synthesis - Collagen for tendon remodelling

开始日期2024-02-28

申办/合作机构

HAN University of Applied Sciences

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项与 HAN University of Applied Sciences 相关的文献（医药）

2025-06-01·Intensive and Critical Care Nursing

Exploring differences in reported mental health outcomes and quality of life between physically restrained and non-physically restrained ICU patients; a prospective cohort study

Article

作者: Francken, L ; Zegers, M ; Rood, P J T ; van den Boogaard, M ; Teerenstra, S ; Peters, M A A

BACKGROUNDPhysical restraints are frequently used in ICU patients, while their effects are unclear.OBJECTIVETo explore differences in patient reported mental health outcomes and quality of life between physical restrained and non-physical restrained ICU patients at 3- and 12-months post ICU admission, compared to pre-ICU health status.RESEARCH METHODOLOGY/DESIGNProspective cohort study. Patients were included when 16 years or older, admitted for at least 12 h and provided informed consent. Differences between groups were analysed using linear mixed model analyses.SETTINGTwo ICUs, a 35 bed academic ICU and a 12 bed ICU in a teaching hospital in the Netherlands.MAIN OUTCOME MEASURESSymptoms of anxiety and depression were measured using the Hospital Anxiety and Depression Scale, post-traumatic stress disorder using the Impact of Event Scale-Revised, and Quality of life using the Short Form-36 scores.RESULTS2,764 patients were included, of which 486 (17.6 %) were physically restrained for median 2 [IQR 1-6] days. Significantly worse outcomes were reported at 3-months by physically restrained patients (symptoms of depression 0.89, 95 %CI 0.37 to 1.41, p < 0.001; PCS -2.82, 95 %CI -4.47 to -1,17p < 0.001; MCS -2.67, 95 %CI -4.39 to -0.96, p < 0.01). At 12-months, only the PCS scores remained significantly lower (-1.71, 95 %CI -3.42 to -0.004, p < 0.05).CONCLUSIONUse of physical restraints is associated with worse self-reported symptoms of depression and decreased quality of life 3-months post ICU, and lower physical quality of life after 12-months.IMPLICATIONS FOR CLINICAL PRACTICEUse of physical restraints is associated with statistical significant worse mental and physical outcomes.

2025-02-01·Patient Education and Counseling

Informal caregivers’ roles and needs regarding shared decision-making in severe aortic stenosis

Article

作者: Minkman, Mirella M.N. ; van Geldorp, Martijn W.A. ; Van den Branden, Ben J.L. ; van der Meer, Jop B.L. ; van Beek-Peeters, Judith J.A.M. ; van der Meer, Nardo J M ; Habibovic, Mirela ; Minkman, Mirella M N ; Van den Branden, Ben J L ; van Beek-Peeters, Judith J A M ; Pel-Littel, Ruth E. ; Faes, Miriam C ; van der Meer, Nardo J.M. ; van der Meer, Jop B L ; van Geldorp, Martijn W A ; Faes, Miriam C. ; Pel-Littel, Ruth E

OBJECTIVETo provide insight into experiences, preferences and needs of informal caregivers (ICs) regarding shared decision-making (SDM) in severe aortic stenosis (AS) of patients ≥ 70 years, and the effect of the level of perceived SDM on ICs' quality of life (QOL) and distress.METHODSMultiple methods study consisting of a questionnaire at baseline and 3-month follow-up and focus groups.RESULTSNinety-nine ICs (67.6 ± 11.7 years) completed the baseline questionnaire, eighty-two ICs the follow-up questionnaire, ten ICs (70.6 ± 12.6 years) participated in two focus groups. ICs perceived that identifying them as discussion partners and addressing patients' daily lives were least discussed with professionals (26.3 %; 59.6 %). Most ICs (63.9 %) preferred a collaborative decision-making (DM) role. The level of perceived SDM was positively associated with baseline QOL social relations (p = .038), and follow-up QOL psychological health (p = .048) and environment (p = .024). ICs experienced three roles in SDM: supporters in DM, stimulators in clarifying patient's personal context, and DM partners.CONCLUSIONICs play valuable roles in SDM for severe AS, but feel professionals do not consistently identify them as discussion partners.PRACTICE IMPLICATIONSProfessionals should involve ICs in SDM for discussing older patient's QOL and personal context, which can inform personalized decisions regarding severe AS treatment.

2025-02-01·Clinical Biomechanics

Can summary measures of magnitude and structure of trunk movement variability differentiate between people with and without chronic low back pain?

Article

作者: Kouyoumdjian, Pascal ; Dupeyron, Arnaud F ; van Dieën, Jaap H ; Demattei, Christophe ; Staal, J Bart ; Graham, Ryan B ; Homs, Alexis F ; Bakar, Florian Abu

BACKGROUNDThere is inconsistent evidence suggesting that people with chronic low back pain may differ in variability of repeated trunk movements compared to people without chronic low back pain. These inconsistencies may be due to low reliability and task dependence of movement variability measures, which can be addressed using multiple movement tasks and summary measures.METHODSParticipants with and without chronic low back pain were recruited. Measurement sessions involved 30 repetitions of movements in the sagittal, transverse, and combined planes. Kinematics of the pelvis, thorax, and lumbar spine were estimated using inertial sensors placed on the sacrum and thorax. Magnitude of movement variability was quantified as the mean standard deviation of Euler angles for the thorax, pelvis, and lumbar spine across normalized cycles for each movement axes, resulting in 27 variables. Additionally, structure of variability was assessed using Lyapunov exponents for local dynamic stability, yielding 9 additional variables. Principal Component Analysis reduced the dimensionality of each variability measure (magnitude and structure). Stepwise logistic regression with principal component scores tested for differences between groups.FINDINGSIn the magnitude of variability analysis, four principal components were retained. The first two principal components significantly differentiated between people with low back pain and controls, accounting for 32.5 % and 14 % of the total variance, respectively. In the structure of variability analysis, no principal components were found to significantly contribute to differentiating between the two groups.INTERPRETATIONSummary measures of the magnitude, but not the structure, of trunk movement variability differentiated between people with and without chronic low back pain.CLINICAL TRIALNCT02059317, CPP: 2013.11.09bis Sud Méditerranée III, N° RCB: 2013-A01379-36.

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