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概览

疾病领域	数量

神经系统疾病	1

排名前五的药物类型	数量

小分子化药	1

排名前五的靶点	数量

BACE1 x GSK-3β	1

关联

1

项与 Buraydah Private Colleges 相关的药物

F1094-0201

靶点

BACE1 x GSK-3β

作用机制

BACE1抑制剂 [+1]

在研机构

Buraydah Private Colleges

原研机构

Buraydah Private Colleges

在研适应症

阿尔茨海默症

非在研适应症-

最高研发阶段临床前

首次获批国家/地区-

首次获批日期-

100 项与 Buraydah Private Colleges 相关的临床结果

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0 项与 Buraydah Private Colleges 相关的专利（医药）

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78

项与 Buraydah Private Colleges 相关的文献（医药）

2025-12-01·International Journal of Engineering Business Management

Wireless body area network: Architecture and security mechanism for healthcare using internet of things

作者: Elaraby, Ahmed ; Kumar, Arun ; Bhushan, Bharat ; Islam, Sardar MN ; Dewan, Ritu ; Giri, Jayant ; Subhi Al-Dayyeni, Wisam

Internet of Things (IoT) enabled wireless body area network (WBAN) is a novel technology that combines medical, wireless, and non-medical devices for healthcare management applications. Indoor healthcare institutions, such as hospitals, may employ IoT devices to manage medical equipment, maintain inventory, and monitor patients. In addition to monitoring temperature, humidity, and air quality, IoT sensors may help prevent the spread of sickness. The data generated by small sensor devices need strong security methods for secure transmission over a public network. Security of the data sent from source to destination is handled by transport layer security (TLS) protocol and prevent message loss or reordering. The most difficult component of TLS is determining how to handle reliability. Low-power wireless networks employ the Datagram Transport Layer Security (DTLS) protocol to solve this problem. But if the Server is exposed to a malicious attack (i.e., flooded with ClientHello messages, the DTLS protocol may no longer serve the purpose) as it may lead to Denial-of-Service (DoS). The paper proposes an intelligent gateway-based verification and approval system to protect health data from IoT wearable devices, a key worldwide data security risk. Paper used Contiki Network Simulator for designing an advanced smart gateway-based constrained application Improved DTLS (CoAP I-DTLS) security protocol. To assess the effectiveness of the proposed work, the packet loss ratio is computed for the CoAP, CoAP-DTLS, and CoAP I-DTLS protocols. To assess the effectiveness of the improved CoAP I-DTLS, calculations are also made for data transfer and handshake time. Paper will also look at ways to increase security by integrating the CoAP I-DTLS protocol with the Secure Hash Algorithm (SHA-256) and utilizing Certificate Authority (CA) improvements. Evaluation parameters such as Packet loss ratio, Data transmission time, and Energy consumption average are considered and detailed simulation results have been presented.

2025-05-24·Journal of Biomolecular Structure and Dynamics

Investigating the effects of four medicinal plants against dengue virus through QSAR modeling and molecular dynamics studies

Article

作者: Khan, Shamshir ; Alam, Aftab ; Alotaibi, Faisal ; Warsi, Mohiuddin Khan ; Aba Alkhayl, Faris F. ; Jawaid, Talha ; Foudah, Ahmed I. ; Rehman, Zia ur ; Moglad, Ehssan H. ; Azhar Kamal, Mohammad

The Dengue virus (DENV) has been increasingly recognized as a prevalent viral pathogen responsible for global transmission of infection. It has been established that DENV's NS5 methyltransferase (MTase) controls viral replication. As a result, NS5 MTase is considered a potentially useful drug target for DENV. In this study, the two phases of virtual screening were conducted using the ML-based QSAR model and molecular docking to identify potential compounds against NS5 of DENV. Four medicinal plants [Aloe vera, Cannabis sativa (Hemp), Ocimum sanctum (Holy Basil; Tulsi), and Zingiber officinale (Ginger)] that showed anti-viral properties were selected for sourcing the phytochemicals and screening them against NS5. Additionally, re-docking at higher exhaustiveness and interaction analysis were performed which resulted in the identification of the top four hits (135398658, 5281675, 119394, and 969516) which showed comparable results with the control Sinefungin (SFG). Post molecular dynamics simulation, 135398658 showed the lowest RMSD (0.4-0.5 nm) and the maximum number of hydrogen bonds (eight hydrogen bonds) after the control while 5281675 and 969516 showed comparable hydrogen bonds to the control. These compounds showed direct interactions with the catalytic site residues GLU111 and ASP131, in addition to this these compounds showed stable complex formation as depicted by principal component analysis and free energy landscape. 135398658 showed lower total binding free energy (ΔG_Total = -36.56 kcal/mol) than the control, while 5281675 had comparable values to the control (ΔG_Total = -34.1 kcal/mol). Overall, the purpose of this study was to identify phytochemicals that inhibit NS5 function, that could be further tested experimentally to treat dengue virus (DENV).

2025-05-01·Pathology - Research and Practice

Therapeutic potential of phytocompounds in rheumatoid arthritis: Molecular insights and clinical applications

Review

作者: Kumar, V Santhosh ; Fahaid Al Fahaid, Ali Audah ; Sweilam, Sherouk Hussein ; Ethiraj, Susithra ; Begh, Md Zamshed Alam ; Devi, Kadirivel ; Khan, Sharuk L ; Reza, Faruk ; Zehravi, Mehrukh ; Rab, Safia Obaidur ; Emran, Talha Bin ; Arjun, Uppuluri Varuna Naga Venkata ; Shanmugarajan, Thukani Sathanantham ; Thilagam, E

Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by systemic involvement, inflammation, and the destruction of synovial joints. RA can be categorized as anti-citrullinated protein antibodies-positive or negative based on genetic risk factors and autoantibodies. This review systematically sourced articles related to RA, phytocompounds, signaling pathways, and clinical insights from primary medical databases, including Scopus, PubMed, and Web of Science. This review explores the therapeutic potential of phytocompounds in treating RA by targeting key inflammation and immunological response signaling pathways. Phytocompounds such as curcumin, resveratrol, and flavonoids alter essential molecular pathways in RA pathophysiology, including nuclear factor kappa-light-chain-enhancer of activated B cells, mitogen-activated protein kinases, janus kinase-signal transducer and activator of transcription, and the inflammasome. These substances possess pro-resolving, anti-apoptotic, and antioxidant properties, which enhance their therapeutic efficacy. Alternative medicine, including dietary, herbal, and nutritional supplements, may help reduce RA symptoms. In vitro, in vivo, and clinical studies have demonstrated the effectiveness of these treatments. Phytocompounds have potential as a treatment for RA by altering signaling pathways, reducing oxidative stress, and protecting cartilage and bone. However, few clinical trials confirm its long-term safety, bioavailability, and effectiveness. Further clinical trials and translational research are needed to validate the effectiveness, safety, and pharmacokinetics of phytocompounds, while identifying novel plant-derived bioactive chemicals could improve patient outcomes.

100 项与 Buraydah Private Colleges 相关的药物交易

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100 项与 Buraydah Private Colleges 相关的转化医学

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