Delving into the Latest Updates on Buraydah Private Colleges with Synapse

概览

疾病领域	数量

神经系统疾病	1

排名前五的药物类型	数量

小分子化药	1

排名前五的靶点	数量

BACE1 x GRIN x GSK-3β	1

关联

1

项与 Buraydah Private Colleges 相关的药物

F1094-0201

靶点

BACE1 x GRIN x GSK-3β

作用机制

BACE1抑制剂 [+2]

在研机构

Buraydah Private Colleges

原研机构

Buraydah Private Colleges

在研适应症

阿尔茨海默症

非在研适应症-

最高研发阶段临床前

首次获批国家/地区-

首次获批日期-

100 项与 Buraydah Private Colleges 相关的临床结果

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0 项与 Buraydah Private Colleges 相关的专利（医药）

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18

项与 Buraydah Private Colleges 相关的文献（医药）

2024-12-31·Journal of Taibah University for Science

In-vitro enzyme inhibition, kinetics, molecular docking and dynamics simulation approaches to decoding the mechanism of Ficus virens in cholinesterase inhibition

作者: Alsaweed, Mohammed ; Kamal, Mehnaz ; Jahan, Sadaf ; Rehman, Md Tabish ; Iqbal, Danish ; Albadrani, Hind Muteb ; Hamed, Munerah ; Jamal, Qazi Mohammad Sajid ; Alasiry, Sharifa M.

2024-10-01·Chemico-Biological Interactions

Alkaloid-based modulators of the PI3K/Akt/mTOR pathway for cancer therapy: Understandings from pharmacological point of view

Review

作者: Emran, Talha Bin ; Singh, Jyoti ; Prasad, P. Dharani ; Al Amin, Md ; Gupta, Jeetendra Kumar ; Balakrishnan, Anitha ; Vallamkonda, Bhaskar ; Challa, Manjula ; Arjun, Uppuluri Varuna Naga Venkata ; Mokhfi, Fatima Zohra ; Ahmad, Irfan ; Doukani, Koula ; Ali, Syed Salman ; Sweilam, Sherouk Hussein ; Zehravi, Mehrukh ; Prasad, P Dharani

This review aims to summarize the role of alkaloids as potential modulators of the PI3K/Akt/mTOR (PAMT) pathway in cancer therapy. The PAMT pathway plays a critical role in cell growth, survival, and metabolism, and its dysregulation contributes to cancer hallmarks. In healthy cells, this pathway is tightly controlled. However, this pathway is frequently dysregulated in cancers and becomes abnormally active. This can happen due to mutations in genes within the pathway itself or due to other factors. This chronic overactivity promotes cancer hallmarks such as uncontrolled cell division, resistance to cell death, and increased blood vessel formation to nourish the tumor. As a result, the PAMT pathway is a crucial therapeutic target for cancer. Researchers are developing drugs that specifically target different components of this pathway, aiming to turn it off and slow cancer progression. Alkaloids, a class of naturally occurring nitrogen-containing molecules found in plants, have emerged as potential therapeutic agents. These alkaloids can target different points within the PAMT pathway, inhibiting its activity and potentially resulting in cancer cell death or suppression of tumor growth. Research is ongoing to explore the role of various alkaloids in cancer treatment. Berberine reduces mTOR activity and increases apoptosis by targeting the PAMT pathway, inhibiting cancer cell proliferation. Lycorine inhibits Akt phosphorylation and mTOR activation, increasing pro-apoptotic protein production and decreasing cell viability. In glioblastoma models, harmine suppresses mTORC1. This review focuses on alkaloids such as evodiamine, hirsuteine, chaetocochin J, indole-3-carbinol, noscapine, berberine, piperlongumine, and so on, which have shown promise in targeting the PAMT pathway. Clinical studies evaluating alkaloids as part of cancer treatment are underway, and their potential impact on patient outcomes is being investigated. In summary, alkaloids represent a promising avenue for targeting the dysregulated PAMT pathway in cancer, and further research is warranted.

2024-09-26·Demonstratio Mathematica

Some Hardy's inequalities on conformable fractional calculus

作者: AlNemer, Ghada ; Zakarya, Mohammed ; Saker, Samir H. ; Kenawy, Mohammed R. ; Ashry, Gehad M. ; Rezk, Haytham M.

AbstractIn this article, we will demonstrate some Hardy’s inequalities by utilizing Hölder inequality, integration by parts, and chain rule of the conformable fractional calculus. When

α=1

\alpha =1

, we can obtain some of classical Copson’s and Hardy’s inequalities. In the end, we will obtain an application of Hardy’s inequality utilizing the conformable fractional calculus.

100 项与 Buraydah Private Colleges 相关的药物交易

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100 项与 Buraydah Private Colleges 相关的转化医学

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